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    Ankrd55 ankyrin repeat domain 55 [ Mus musculus (house mouse) ]

    Gene ID: 77318, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ankrd55provided by MGI
    Official Full Name
    ankyrin repeat domain 55provided by MGI
    Primary source
    MGI:MGI:1924568
    See related
    Ensembl:ENSMUSG00000049985 AllianceGenome:MGI:1924568
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C030011J08Rik
    Summary
    Is expressed in limb. Orthologous to human ANKRD55 (ankyrin repeat domain 55). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 1.5), cerebellum adult (RPKM 1.1) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 D2.2; 13 63.73 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (112424985..112523391)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (112288451..112384005)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35683 Neighboring gene predicted gene, 33849 Neighboring gene STARR-seq mESC enhancer starr_35685 Neighboring gene predicted gene, 53816 Neighboring gene STARR-positive B cell enhancer ABC_E7287 Neighboring gene STARR-seq mESC enhancer starr_35687 Neighboring gene predicted gene, 41065 Neighboring gene predicted gene, 48837 Neighboring gene STARR-positive B cell enhancer mm9_chr13:113188373-113188674 Neighboring gene STARR-seq mESC enhancer starr_35690 Neighboring gene STARR-seq mESC enhancer starr_35691 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:113214843-113215211 Neighboring gene predicted gene, 33905 Neighboring gene STARR-positive B cell enhancer mm9_chr13:113223673-113223974 Neighboring gene STARR-positive B cell enhancers ABC_E5418 and ABC_E4097 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:113229709-113229897 Neighboring gene STARR-positive B cell enhancer ABC_E1890 Neighboring gene STARR-positive B cell enhancer ABC_E8545 Neighboring gene STARR-seq mESC enhancer starr_35693 Neighboring gene interleukin 6 signal transducer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 55

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168403.1 → NP_001161875.1  ankyrin repeat domain-containing protein 55 isoform 2

      See identical proteins and their annotated locations for NP_001161875.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' region, as compared to variant 1. This results in a downstream AUG start codon and the resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK021066, AK039553, AK045480, AK140417
      Consensus CDS
      CCDS49365.1
      UniProtKB/TrEMBL
      A7MCU1, E9Q0E9
      Related
      ENSMUSP00000126199.2, ENSMUST00000165593.9
      Conserved Domains (2) summary
      PHA03095
      Location:3 → 286
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:64 → 95
      ANK; ANK repeat [structural motif]

    2. NM_001168404.1 → NP_001161876.1  ankyrin repeat domain-containing protein 55 isoform 3

      See identical proteins and their annotated locations for NP_001161876.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a split 5' exon and lacks several 3' exons but has an alternate 3' segment, as compared to variant 1. The resulting isoform (3) is much shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK081197
      Consensus CDS
      CCDS49364.1
      UniProtKB/TrEMBL
      Q8BV14
      Related
      ENSMUSP00000129726.2, ENSMUST00000168684.2
      Conserved Domains (4) summary
      cd00204
      Location:120 → 249
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:97 → 191
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:196 → 249
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:92 → 123
      ANK; ANK repeat [structural motif]

    3. NM_001168405.1 → NP_001161877.1  ankyrin repeat domain-containing protein 55 isoform 4

      See identical proteins and their annotated locations for NP_001161877.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks multiple 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (4) is much shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK039553
      Consensus CDS
      CCDS49363.1
      UniProtKB/TrEMBL
      Q8BYH9
      Related
      ENSMUSP00000058891.8, ENSMUST00000056047.14
      Conserved Domains (3) summary
      cd00204
      Location:33 → 146
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:31 → 123
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:59 → 90
      ANK; ANK repeat [structural motif]

    4. NM_029898.3 → NP_084174.2  ankyrin repeat domain-containing protein 55 isoform 1

      See identical proteins and their annotated locations for NP_084174.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK021066, AK039553, AK045480, AK138273, BC152317
      Consensus CDS
      CCDS26772.1
      UniProtKB/Swiss-Prot
      E9QPX4, Q3UUM0, Q8BLD6, Q9CTM6
      UniProtKB/TrEMBL
      A7MCU1
      Related
      ENSMUSP00000022275.7, ENSMUST00000022275.14
      Conserved Domains (2) summary
      PHA03095
      Location:20 → 314
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:92 → 123
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      112424985..112523391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158223.1 → XP_036014116.1  ankyrin repeat domain-containing protein 55 isoform X3

      Conserved Domains (2) summary
      PHA03095
      Location:20 → 314
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:92 → 123
      ANK; ANK repeat [structural motif]

    2. XM_006517789.4 → XP_006517852.1  ankyrin repeat domain-containing protein 55 isoform X1

      See identical proteins and their annotated locations for XP_006517852.1

      UniProtKB/Swiss-Prot
      E9QPX4, Q3UUM0, Q8BLD6, Q9CTM6
      UniProtKB/TrEMBL
      A7MCU1
      Conserved Domains (2) summary
      PHA03095
      Location:20 → 314
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:92 → 123
      ANK; ANK repeat [structural motif]

    3. XM_017315640.3 → XP_017171129.1  ankyrin repeat domain-containing protein 55 isoform X6

      Conserved Domains (2) summary
      PHA03095
      Location:20 → 314
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:92 → 123
      ANK; ANK repeat [structural motif]

    4. XM_036158222.1 → XP_036014115.1  ankyrin repeat domain-containing protein 55 isoform X2

      UniProtKB/TrEMBL
      A7MCU1, E9Q0E9
      Conserved Domains (2) summary
      PHA03095
      Location:3 → 286
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:64 → 95
      ANK; ANK repeat [structural motif]

    5. XM_006517791.5 → XP_006517854.1  ankyrin repeat domain-containing protein 55 isoform X2

      See identical proteins and their annotated locations for XP_006517854.1

      UniProtKB/TrEMBL
      A7MCU1, E9Q0E9
      Conserved Domains (2) summary
      PHA03095
      Location:3 → 286
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:64 → 95
      ANK; ANK repeat [structural motif]

    6. XM_017315639.3 → XP_017171128.1  ankyrin repeat domain-containing protein 55 isoform X2

      UniProtKB/TrEMBL
      A7MCU1, E9Q0E9
      Conserved Domains (2) summary
      PHA03095
      Location:3 → 286
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:64 → 95
      ANK; ANK repeat [structural motif]

    7. XM_036158224.1 → XP_036014117.1  ankyrin repeat domain-containing protein 55 isoform X5

      Conserved Domains (2) summary
      sd00045
      Location:45 → 76
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:46 → 98
      Ank_4; Ankyrin repeats (many copies)

    8. XM_006517792.4 → XP_006517855.1  ankyrin repeat domain-containing protein 55 isoform X4

      Conserved Domains (2) summary
      sd00045
      Location:75 → 106
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:76 → 128
      Ank_4; Ankyrin repeats (many copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLD6.2 GenPept UniProtKB/Swiss-Prot:Q8BLD6

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