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    Rassf8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 [ Mus musculus (house mouse) ]

    Gene ID: 71323, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rassf8provided by MGI
    Official Full Name
    Ras association (RalGDS/AF-6) domain family (N-terminal) member 8provided by MGI
    Primary source
    MGI:MGI:1918573
    See related
    Ensembl:ENSMUSG00000030259 AllianceGenome:MGI:1918573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hoj1; mHoj-1; 5133400D11Rik
    Summary
    Predicted to be involved in signal transduction. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; gut; and quadriceps femoris muscle. Orthologous to human RASSF8 (Ras association domain family member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 11.3), limb E14.5 (RPKM 7.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 G3; 6 77.68 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145692292..145766805)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145746561..145821079)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene lamin tail domain containing 1 Neighboring gene predicted gene, 25373 Neighboring gene tubulin, alpha 3B Neighboring gene predicted gene 15704 Neighboring gene STARR-positive B cell enhancer mm9_chr6:145778656-145778957 Neighboring gene VISTA enhancer mm1548 Neighboring gene predicted gene, 38927 Neighboring gene basic helix-loop-helix family, member e41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-kappaB signaling pathways. Lock FE, et al. Oncogene, 2010 Jul 29. PMID 20514026
    2. A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands. Giallourakis C, et al. Genome Res, 2006 Aug. PMID 16825666, Free PMC Article
    3. Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines. Wang M, et al. Cancer Res, 2003 Jun 15. PMID 12810665
    4. Genetic predisposition to tinnitus in the UK Biobank population. Urbanek ME, et al. Sci Rep, 2021 Sep 13. PMID 34518561, Free PMC Article
    5. The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Schilling K, et al. Cerebellum, 2009 Dec. PMID 19554387

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144731, MGC144732

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras association domain-containing protein 8
    Names
    carcinoma-associated protein HOJ-1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027760.3 → NP_082036.1  ras association domain-containing protein 8

      See identical proteins and their annotated locations for NP_082036.1

      Status: VALIDATED

      Source sequence(s)
      AC138117, BC115779, CJ062665
      Consensus CDS
      CCDS20696.1
      UniProtKB/Swiss-Prot
      Q149Q5, Q8CCW4, Q8CJ96, Q9CU91
      Related
      ENSMUSP00000107333.2, ENSMUST00000111704.8
      Conserved Domains (2) summary
      COG1196
      Location:109 → 380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      145692292..145766805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241599.3 → XP_011239901.1  ras association domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_011239901.1

      UniProtKB/Swiss-Prot
      Q149Q5, Q8CCW4, Q8CJ96, Q9CU91
      Conserved Domains (2) summary
      COG1196
      Location:109 → 380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

    2. XM_036152307.1 → XP_036008200.1  ras association domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      Q149Q5, Q8CCW4, Q8CJ96, Q9CU91
      Conserved Domains (2) summary
      COG1196
      Location:109 → 380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16134
      Location:2 → 83
      RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CJ96.1 GenPept UniProtKB/Swiss-Prot:Q8CJ96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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