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    Oxsm 3-oxoacyl-ACP synthase, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 71147, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Oxsmprovided by MGI
    Official Full Name
    3-oxoacyl-ACP synthase, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1918397
    See related
    Ensembl:ENSMUSG00000021786 AllianceGenome:MGI:1918397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933425A18Rik
    Summary
    Predicted to enable 3-oxoacyl-[acyl-carrier-protein] synthase activity. Predicted to be involved in acyl-CoA metabolic process; medium-chain fatty acid biosynthetic process; and short-chain fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in dorsal root ganglion; lung; nervous system; peripheral nervous system; and respiratory system. Orthologous to human OXSM (3-oxoacyl-ACP synthase, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 4.1), testis adult (RPKM 3.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 A1; 14 7.08 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (6219955..6231111)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (16238652..16249808, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor, beta Neighboring gene STARR-seq mESC enhancer starr_36026 Neighboring gene predicted gene, 53820 Neighboring gene predicted gene, 46442 Neighboring gene STARR-seq mESC enhancer starr_36025 Neighboring gene STARR-positive B cell enhancer ABC_E1166 Neighboring gene STARR-seq mESC enhancer starr_36024 Neighboring gene topoisomerase (DNA) II beta Neighboring gene STARR-seq mESC enhancer starr_36023 Neighboring gene STARR-seq mESC enhancer starr_36022 Neighboring gene N-glycanase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:17005903-17006137 Neighboring gene ribosomal protein L31, pseudogene 3 Neighboring gene ribosomal protein L4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reduction of mitochondrial 3-oxoacyl-ACP synthase (OXSM) by hyperglycemia is associated with deficiency of α-lipoic acid synthetic pathway in kidney of diabetic mice. Gao T, et al. Biochem Biophys Res Commun, 2019 Apr 23. PMID 30871779
    2. Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain. Zhang L, et al. J Biol Chem, 2005 Apr 1. PMID 15668256
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in medium-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in short-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
    Names
    beta-ketoacyl-ACP synthase
    NP_001346811.1
    NP_001346812.1
    NP_081971.1
    XP_006518164.1
    XP_006518165.1
    XP_006518166.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359882.1 → NP_001346811.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC173482, AK016905, AK034243, BG229916
      Consensus CDS
      CCDS26831.1
      UniProtKB/Swiss-Prot
      Q9D404
      UniProtKB/TrEMBL
      Q148P2
      Conserved Domains (1) summary
      cd00834
      Location:42 → 456
      KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...

    2. NM_001359883.1 → NP_001346812.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC173482, AK034243, AK084829, BG229916
      Consensus CDS
      CCDS26831.1
      UniProtKB/Swiss-Prot
      Q9D404
      UniProtKB/TrEMBL
      Q148P2
      Related
      ENSMUSP00000108244.2, ENSMUST00000112625.9
      Conserved Domains (1) summary
      cd00834
      Location:42 → 456
      KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...

    3. NM_027695.4 → NP_081971.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_081971.1

      Status: VALIDATED

      Source sequence(s)
      AC173482, AK034243, AK083617, BG229916
      Consensus CDS
      CCDS26831.1
      UniProtKB/Swiss-Prot
      Q9D404
      UniProtKB/TrEMBL
      Q148P2
      Related
      ENSMUSP00000022311.5, ENSMUST00000022311.12
      Conserved Domains (1) summary
      cd00834
      Location:42 → 456
      KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      6219955..6231111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518101.4 → XP_006518164.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006518164.1

      UniProtKB/Swiss-Prot
      Q9D404
      UniProtKB/TrEMBL
      Q148P2
      Related
      ENSMUSP00000108243.2, ENSMUST00000112624.3
      Conserved Domains (1) summary
      cd00834
      Location:42 → 456
      KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...

    2. XM_006518103.5 → XP_006518166.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006518166.1

      UniProtKB/Swiss-Prot
      Q9D404
      UniProtKB/TrEMBL
      Q148P2
      Conserved Domains (1) summary
      cd00834
      Location:42 → 456
      KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...

    3. XM_006518102.2 → XP_006518165.1  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006518165.1

      UniProtKB/Swiss-Prot
      Q9D404
      UniProtKB/TrEMBL
      Q148P2
      Conserved Domains (1) summary
      cd00834
      Location:42 → 456
      KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D404.1 GenPept UniProtKB/Swiss-Prot:Q9D404

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