Dpm3 dolichyl-phosphate mannosyltransferase polypeptide 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpm3provided by MGI
Official Full Name: dolichyl-phosphate mannosyltransferase polypeptide 3provided by MGI
Primary source: MGI:MGI:1915813
See related: Ensembl:ENSMUSG00000042737 AllianceGenome:MGI:1915813
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110001H19Rik
Summary: Predicted to enable enzyme activator activity. Predicted to be involved in GPI anchor biosynthetic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and muscular dystrophy-dystroglycanopathy. Orthologous to human DPM3 (dolichyl-phosphate mannosyltransferase subunit 3, regulatory). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 62.7), mammary gland adult (RPKM 54.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.03 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89166567..89174386)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89257065..89267079)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GPI anchor biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dolichol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of dolichol-phosphate-mannose synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dolichol-phosphate-mannose synthase complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dolichol-phosphate mannosyltransferase subunit 3

Names: DPM synthase complex subunit 3; DPM synthase subunit 3; MPD synthase subunit 3; dolichol-phosphate mannose synthase subunit 3; dolichyl-phosphate beta-D-mannosyltransferase subunit 3; mannose-P-dolichol synthase subunit 3

NP_081043.1

EC 2.4.1.83

XP_006502046.1

EC 2.4.1.83

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.