Ufm1 ubiquitin-fold modifier 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ufm1provided by MGI
Official Full Name: ubiquitin-fold modifier 1provided by MGI
Primary source: MGI:MGI:1915140
See related: Ensembl:ENSMUSG00000027746 AllianceGenome:MGI:1915140
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm10726; 1810045K17Rik
Summary: Involved in protein ufmylation and response to endoplasmic reticulum stress. Located in endoplasmic reticulum and nucleus. Is expressed in embryo and pancreas epithelium. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 14. Orthologous to human UFM1 (ubiquitin fold modifier 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 8.7), bladder adult (RPKM 8.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 C; 3 25.43 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (53760797..53771228, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (53853376..53863807, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice.
Title: Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice.
The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.
Title: The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.
Deficiency of Murine UFM1-Specific E3 Ligase Causes Microcephaly and Inflammation.
Title: Deficiency of Murine UFM1-Specific E3 Ligase Causes Microcephaly and Inflammation.
UFMylation inhibits the proinflammatory capacity of interferon-gamma-activated macrophages.
Title: UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages.
Ubiquitin fold modifier 1 activates NF-kappaB pathway by down-regulating LZAP expression in the macrophage of diabetic mouse model.
Title: Ubiquitin fold modifier 1 activates NF-κB pathway by down-regulating LZAP expression in the macrophage of diabetic mouse model.
Ufmylation may participate in regulation of the vascular smooth muscle cells phenotypic switch and endothelial cell injury, which may help in the understanding of vascular remodeling.
Title: Ufmylation Is Activated in Vascular Remodeling and Lipopolysaccharide-Induced Endothelial Cell Injury.
CNS-specific knockout of Ufm1 in mice causes neonatal death accompanied by microcephaly and apoptosis in specific neurons, further suggesting that the UFM1 system is essential for CNS development and function
Title: Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.
High UFM1 expression is associated with Atherosclerosis.
Title: UFM1 Protects Macrophages from oxLDL-Induced Foam Cell Formation Through a Liver X Receptor α Dependent Pathway.
transcription downregulation of the Ufm1 and FAT10 conjugation system in liver Mallory-Denk bodies formation
Title: Ufmylation and FATylation pathways are downregulated in human alcoholic and nonalcoholic steatohepatitis, and mice fed DDC, where Mallory-Denk bodies (MDBs) form.
These data suggest that UFM1-UFBP1 participate in preventing ER stress-induced apoptosis in protein secretory cells.
Title: Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI132708 (e-PCR)
- UniSTS:159109

AI463323 (e-PCR)
- UniSTS:159110

NoName (e-PCR)
- UniSTS:234668

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein K69-linked ufmylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K69-linked ufmylation	ISO Inferred from Sequence Orthology more info
involved_in protein ufmylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ufmylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info	PubMed
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in reticulophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin-fold modifier 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.