Abhd15 abhydrolase domain containing 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abhd15provided by MGI
Official Full Name: abhydrolase domain containing 15provided by MGI
Primary source: MGI:MGI:1914727
See related: Ensembl:ENSMUSG00000000686 AllianceGenome:MGI:1914727
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1300007F04Rik
Summary: Predicted to enable acylglycerol lipase activity and short-chain carboxylesterase activity. Predicted to be involved in cellular lipid metabolic process. Predicted to be located in extracellular region. Is expressed in brown fat; liver; testis; and white fat. Orthologous to human ABHD15 (abhydrolase domain containing 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 15.4), subcutaneous fat pad adult (RPKM 13.9) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.63 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (77405943..77411454)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (77515117..77520628)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ABHD15 protein levels were reduced in adipocytes from mice fed a Western diet, further implicating this protein in metabolic homeostasis.
Title: ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation.
ABHD15 associates with and stabilizes phosphodiesterase 3B (PDE3B).
Title: Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance.
ABHD15 is an essential component in the development of adipocytes as well as in apoptosis.
Title: α/β-hydrolase domain containing protein 15 (ABHD15)--an adipogenic protein protecting from apoptosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables short-chain carboxylesterase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adipose tissue development	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein ABHD15

Names: abhydrolase domain-containing protein 15; alpha/beta hydrolase domain-containing protein 15

NP_080461.3

EC 3.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.