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    Dcbld1 discoidin, CUB and LCCL domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 66686, updated on 18-Apr-2024

    Summary

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    Official Symbol
    Dcbld1provided by MGI
    Official Full Name
    discoidin, CUB and LCCL domain containing 1provided by MGI
    Primary source
    MGI:MGI:1913936
    See related
    Ensembl:ENSMUSG00000019891 AllianceGenome:MGI:1913936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4631413K11Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in blood microparticle. Is expressed in Meckel's cartilage and skeleton. Orthologous to human DCBLD1 (discoidin, CUB and LCCL domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 9.1), large intestine adult (RPKM 8.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B3; 10 26.41 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (52109674..52197474)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (52233578..52321378)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Ros1 proto-oncogene Neighboring gene predicted gene 20630 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26667 Neighboring gene STARR-seq mESC enhancer starr_26670 Neighboring gene STARR-seq mESC enhancer starr_26671 Neighboring gene STARR-seq mESC enhancer starr_26672 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene golgi associated PDZ and coiled-coil motif containing Neighboring gene ribosomal protein S19, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Yoshida Y, et al. Neuron, 2006 Dec 7. PMID 17145500, Free PMC Article
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    discoidin, CUB and LCCL domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347444.1 → NP_001334373.1  discoidin, CUB and LCCL domain-containing protein 1 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AC153525, AK014521, AK016485, AV229589, BY096153
      Consensus CDS
      CCDS83696.1
      UniProtKB/Swiss-Prot
      Q9D4J3
      Related
      ENSMUSP00000151265.2, ENSMUST00000218582.2

    2. NM_025705.4 → NP_079981.2  discoidin, CUB and LCCL domain-containing protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_079981.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC153525, AK014521, AK016485, AV229589, BY096153
      Consensus CDS
      CCDS23839.1
      UniProtKB/Swiss-Prot
      Q8R327, Q9D4J3, Q9D696
      Related
      ENSMUSP00000068203.6, ENSMUST00000069004.14
      Conserved Domains (2) summary
      cd00041
      Location:32 → 140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl02694
      Location:147 → 239
      LCCL; LCCL domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      52109674..52197474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243196.2 → XP_011241498.1  discoidin, CUB and LCCL domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      cd00041
      Location:32 → 140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl02694
      Location:165 → 229
      LCCL; LCCL domain

    2. XM_030245220.1 → XP_030101080.1  discoidin, CUB and LCCL domain-containing protein 1 isoform X2

    3. XM_030245221.2 → XP_030101081.1  discoidin, CUB and LCCL domain-containing protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4J3.2 GenPept UniProtKB/Swiss-Prot:Q9D4J3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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