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    MRPS9 mitochondrial ribosomal protein S9 [ Homo sapiens (human) ]

    Gene ID: 64965, updated on 3-Apr-2024

    Summary

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    Official Symbol
    MRPS9provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein S9provided by HGNC
    Primary source
    HGNC:HGNC:14501
    See related
    Ensembl:ENSG00000135972 MIM:611975; AllianceGenome:HGNC:14501
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S9mt; uS9m; RPMS9; MRP-S9
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 14.5), testis (RPKM 14.4) and 25 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    2q12.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (105038069..105099960)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (105499329..105561123)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (105654527..105716418)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:105470177-105470766 Neighboring gene uncharacterized LOC124908045 Neighboring gene Sharpr-MPRA regulatory region 193 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:105488734-105489459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11836 Neighboring gene long intergenic non-protein coding RNA 1159 Neighboring gene POU class 3 homeobox 3 Neighboring gene VISTA enhancer hs990 Neighboring gene MRPS9 antisense RNA 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:105585853-105587052 Neighboring gene Sharpr-MPRA regulatory region 1600 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:105621477-105622097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16311 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:105654567-105655509 Neighboring gene VISTA enhancer hs868 Neighboring gene uncharacterized LOC105373527 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:105719958-105720819 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:105720820-105721680 Neighboring gene MRPS9 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:105725341-105726149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:105735229-105735730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:105735731-105736230 Neighboring gene long intergenic non-protein coding RNA 1918

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA. Ishiguchi H, et al. Int J Cancer, 2004 Oct 10. PMID 15300802
    2. Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach. Koc EC, et al. Protein Sci, 2001 Mar. PMID 11344316, Free PMC Article
    3. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. Yagi M, et al. Nucleic Acids Res, 2012 Oct. PMID 22904065, Free PMC Article
    4. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. Zhu X, et al. FASEB J, 2016 Feb. PMID 26472337
    5. Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening. Falconieri A, et al. Cancers (Basel), 2022 Feb 17. PMID 35205757, Free PMC Article

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway Inhibits Neuron Apoptosis and Protects Ischemic Stroke.
      Title: MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway Inhibits Neuron Apoptosis and Protects Ischemic Stroke.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev is identified to have a physical interaction with mitochondrial ribosomal protein S9 (MRPS9) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS9m
    Names
    28S ribosomal protein S9, mitochondrial
    mitochondrial small ribosomal subunit protein uS9m

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182640.3 → NP_872578.1  small ribosomal subunit protein uS9m

      See identical proteins and their annotated locations for NP_872578.1

      Status: REVIEWED

      Source sequence(s)
      BC036575, BC057240, DT217261
      Consensus CDS
      CCDS2065.1
      UniProtKB/Swiss-Prot
      P82933, Q6PG40
      Related
      ENSP00000258455.3, ENST00000258455.8
      Conserved Domains (1) summary
      pfam00380
      Location:274 → 396
      Ribosomal_S9; Ribosomal protein S9/S16

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      105038069..105099960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445533.1 → XP_047301489.1  small ribosomal subunit protein uS9m isoform X2

    2. XM_011511644.3 → XP_011509946.1  small ribosomal subunit protein uS9m isoform X1

      UniProtKB/TrEMBL
      Q86WV4
      Conserved Domains (1) summary
      pfam00380
      Location:150 → 272
      Ribosomal_S9; Ribosomal protein S9/S16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      105499329..105561123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343427.1 → XP_054199402.1  small ribosomal subunit protein uS9m isoform X3

    2. XM_054343426.1 → XP_054199401.1  small ribosomal subunit protein uS9m isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P82933.2 GenPept UniProtKB/Swiss-Prot:P82933

    Gene LinkOut

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