Tspan4 tetraspanin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tspan4provided by MGI
Official Full Name: tetraspanin 4provided by MGI
Primary source: MGI:MGI:1928097
See related: Ensembl:ENSMUSG00000025511 AllianceGenome:MGI:1928097
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NAG-2; Tm4sf7; Tspan-4; D130042I01Rik
Summary: Predicted to enable antigen binding activity and integrin binding activity. Predicted to be involved in protein-containing complex assembly. Predicted to be located in plasma membrane and vesicle. Predicted to be integral component of plasma membrane. Is expressed in several structures, including gut; jaw; rib cage; urinary system; and viscerocranium. Orthologous to human TSPAN4 (tetraspanin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 100.6), adrenal adult (RPKM 68.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 86.83 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (141055194..141073340)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141475236..141493427)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression.
Title: TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (4)

General gene information

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Markers

RH126879 (e-PCR)
- UniSTS:208226

AI746565 (e-PCR)
- UniSTS:179676

35.MMHAP17FRD11.seq (e-PCR)
- UniSTS:124130

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antigen binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within mitocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mitochondrial membrane potential	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in migrasome	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tetraspanin-4

Names: novel antigen 2; tetraspan TM4SF; transmembrane 4 superfamily member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252588.2 → NP_001239517.1 tetraspanin-4 isoform a

See identical proteins and their annotated locations for NP_001239517.1

Status: VALIDATED

Source sequence(s)

AC158224

Consensus CDS

CCDS22018.1

UniProtKB/Swiss-Prot

Q9DCK3

UniProtKB/TrEMBL

Q4FJW7

Related

ENSMUSP00000113085.2, ENSMUST00000117634.2

Conserved Domains (2) summary

cd03165
Location:105 → 202

NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:9 → 226

Tetraspannin; Tetraspanin family
NM_001403355.1 → NP_001390284.1 tetraspanin-4 isoform a

Status: VALIDATED

Source sequence(s)

AC158224

UniProtKB/Swiss-Prot

Q9DCK3

UniProtKB/TrEMBL

Q4FJW7
NM_001403356.1 → NP_001390285.1 tetraspanin-4 isoform a

Status: VALIDATED

Source sequence(s)

AC158224

UniProtKB/Swiss-Prot

Q9DCK3

UniProtKB/TrEMBL

Q4FJW7
NM_001403357.1 → NP_001390286.1 tetraspanin-4 isoform a

Status: VALIDATED

Source sequence(s)

AC158224

UniProtKB/Swiss-Prot

Q9DCK3

UniProtKB/TrEMBL

Q4FJW7
NM_001403358.1 → NP_001390287.1 tetraspanin-4 isoform b

Status: VALIDATED

Source sequence(s)

AC158224

UniProtKB/TrEMBL

A0A668KLD1

Related

ENSMUSP00000159235.2, ENSMUST00000239217.2
NM_053082.4 → NP_444312.1 tetraspanin-4 isoform a

See identical proteins and their annotated locations for NP_444312.1

Status: VALIDATED

Source sequence(s)

AC158224

Consensus CDS

CCDS22018.1

UniProtKB/Swiss-Prot

Q9DCK3

UniProtKB/TrEMBL

Q4FJW7

Related

ENSMUSP00000026585.8, ENSMUST00000026585.14

Conserved Domains (2) summary

cd03165
Location:105 → 202

NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:9 → 226

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

141055194..141073340

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153326.1 → XP_036009219.1 tetraspanin-4 isoform X3

Conserved Domains (1) summary

cd03165
Location:41 → 138

NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
XM_036153327.1 → XP_036009220.1 tetraspanin-4 isoform X3

Conserved Domains (1) summary

cd03165
Location:41 → 138

NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...