CCL25 C-C motif chemokine ligand 25 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCL25provided by HGNC
Official Full Name: C-C motif chemokine ligand 25provided by HGNC
Primary source: HGNC:HGNC:10624
See related: Ensembl:ENSG00000131142 MIM:602565; AllianceGenome:HGNC:10624
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TECK; Ckb15; SCYA25; TECKvar; Ck beta-15
Summary: This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression: Restricted expression toward small intestine (RPKM 203.4) See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (8052341..8062650)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (8053362..8063660)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (8117225..8127534)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25.
Title: LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25.
CCL25 and CCR9 is a unique pathway that potentiates pannus formation by remodeling RA macrophages into mature osteoclasts.
Title: CCL25 and CCR9 is a unique pathway that potentiates pannus formation by remodeling RA macrophages into mature osteoclasts.
The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes.
Title: The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes.
Intratumoral delivery of CCL25 enhances immunotherapy against triple-negative breast cancer by recruiting CCR9(+) T cells.
Title: Intratumoral delivery of CCL25 enhances immunotherapy against triple-negative breast cancer by recruiting CCR9(+) T cells.
Thymusexpressed chemokine secreted by breast cancer cells promotes metastasis and inhibits apoptosis.
Title: Thymus‑expressed chemokine secreted by breast cancer cells promotes metastasis and inhibits apoptosis.
this study shows increased expression of CCL25 in chronic Rhinosinusitis with Nasal Polyps
Title: Increased Expressions and Roles of CC Chemokine Ligand 21 and CC Chemokine Ligand 25 in Chronic Rhinosinusitis with Nasal Polyps.
CCL25 was able to induce proteoglycan and collagen type I production in anulus fibrosus-derived cells.
Title: Chemokine CCL25 Induces Migration and Extracellular Matrix Production of Anulus Fibrosus-Derived Cells.
It plays a pathogenic role in liver diseases and it will be a therapeutic target of the diseases.
Title: [Role of inflammatory macrophages and CCR9/CCL25 chemokine axis in the pathogenesis of liver injury as a therapeutic target].
TECK was shown to be expressed by osteoblasts, and its receptor, CCR9, by osteoclast precursors. TECK increased P. gingivalis LPS-induced osteoclast numbers in an in vitro osteoclast formation assay using osteoclast precursors. T
Title: Thymus-expressed chemokine enhances Porphyromonas gingivalis LPS-induced osteoclast formation via NFATc1 activation.
that CCL25/CCR9 signal may provide cancer cells with chemotactic abilities through influencing several epithelial-mesenchymal transitionmarkers
Title: CCL25/CCR9 Signal Promotes Migration and Invasion in Hepatocellular and Breast Cancer Cell Lines.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484319

NoName (e-PCR)
- UniSTS:481770

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR10 chemokine receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of leukocyte tethering or rolling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-C motif chemokine 25

Names: chemokine (C-C motif) ligand 25; chemokine TECK; small inducible cytokine subfamily A (Cys-Cys), member 25; small-inducible cytokine A25; thymus expressed chemokine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001201359.2 → NP_001188288.1 C-C motif chemokine 25 isoform 2 precursor

See identical proteins and their annotated locations for NP_001188288.1

Status: REVIEWED

Source sequence(s)

AC008946

Consensus CDS

CCDS56080.1

UniProtKB/TrEMBL

Q08AK2

Related

ENSP00000253451.4, ENST00000253451.9

Conserved Domains (1) summary

cd01119
Location:28 → 91

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
NM_001394634.1 → NP_001381563.1 C-C motif chemokine 25 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC008946

Consensus CDS

CCDS12194.1

UniProtKB/Swiss-Prot

A1L4J4, A6NI52, A8K9E7, B5MCA5, O15444, Q96KJ7

UniProtKB/TrEMBL

C9JDZ7

Related

ENSP00000504875.1, ENST00000680646.1

Conserved Domains (1) summary

cd01119
Location:28 → 91

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
NM_001394635.1 → NP_001381564.1 C-C motif chemokine 25 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC008946

Consensus CDS

CCDS12194.1

UniProtKB/Swiss-Prot

A1L4J4, A6NI52, A8K9E7, B5MCA5, O15444, Q96KJ7

UniProtKB/TrEMBL

C9JDZ7

Conserved Domains (1) summary

cd01119
Location:28 → 91

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
NM_001394636.1 → NP_001381565.1 C-C motif chemokine 25 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC008946

Consensus CDS

CCDS12194.1

UniProtKB/Swiss-Prot

A1L4J4, A6NI52, A8K9E7, B5MCA5, O15444, Q96KJ7

UniProtKB/TrEMBL

C9JDZ7

Related

ENSP00000505422.1, ENST00000680506.1

Conserved Domains (1) summary

cd01119
Location:28 → 91

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
NM_001394637.1 → NP_001381566.1 C-C motif chemokine 25 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC008946

Consensus CDS

CCDS12194.1

UniProtKB/Swiss-Prot

A1L4J4, A6NI52, A8K9E7, B5MCA5, O15444, Q96KJ7

UniProtKB/TrEMBL

C9JDZ7

Conserved Domains (1) summary

cd01119
Location:28 → 91

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
NM_001394638.1 → NP_001381567.1 C-C motif chemokine 25 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC008946

Consensus CDS

CCDS56080.1

UniProtKB/TrEMBL

Q08AK2

Related

ENSP00000506202.1, ENST00000680450.1

Conserved Domains (1) summary

cd01119
Location:28 → 91

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
NM_005624.4 → NP_005615.2 C-C motif chemokine 25 isoform 1 precursor

See identical proteins and their annotated locations for NP_005615.2

Status: REVIEWED

Source sequence(s)

AC008946

Consensus CDS

CCDS12194.1

UniProtKB/Swiss-Prot

A1L4J4, A6NI52, A8K9E7, B5MCA5, O15444, Q96KJ7

UniProtKB/TrEMBL

C9JDZ7

Related

ENSP00000324756.6, ENST00000315626.6

Conserved Domains (1) summary

cd01119
Location:28 → 91

Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

8052341..8062650

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047439203.1 → XP_047295159.1 C-C motif chemokine 25 isoform X1
XM_047439204.1 → XP_047295160.1 C-C motif chemokine 25 isoform X2

UniProtKB/Swiss-Prot

A1L4J4, A6NI52, A8K9E7, B5MCA5, O15444, Q96KJ7
XM_047439205.1 → XP_047295161.1 C-C motif chemokine 25 isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

8053362..8063660

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321712.1 → XP_054177687.1 C-C motif chemokine 25 isoform X1
XM_054321713.1 → XP_054177688.1 C-C motif chemokine 25 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_148888.1: Suppressed sequence

Description

NM_148888.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.