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    Trpm7 transient receptor potential cation channel, subfamily M, member 7 [ Mus musculus (house mouse) ]

    Gene ID: 58800, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Trpm7provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily M, member 7provided by MGI
    Primary source
    MGI:MGI:1929996
    See related
    Ensembl:ENSMUSG00000027365 AllianceGenome:MGI:1929996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CHAK; CHAK1; Ltpr7; Ltrpc7; LTrpC-7; TRPPLIK; 2310022G15Rik; 4833414K03Rik; 5033407O22Rik
    Summary
    Enables calcium channel activity; cytoskeletal protein binding activity; and kinase activity. Acts upstream of or within several processes, including calcium ion transport; calcium-dependent cell-matrix adhesion; and protein autophosphorylation. Located in plasma membrane and ruffle. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and skin. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 10.3), CNS E11.5 (RPKM 10.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F1; 2 61.76 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126633478..126718181, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126791558..126876261, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L pseudogene Neighboring gene ubiquitin specific peptidase 8 Neighboring gene ubiquitin specific peptidase 50 Neighboring gene STARR-positive B cell enhancer ABC_E11158 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 pseudogene Neighboring gene signal peptide peptidase like 2A Neighboring gene microRNA 3473g

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer's disease. Zhang S, et al. Sci Signal, 2023 Jul 11. PMID 37433006
    2. TRPM7 kinase mediates hypomagnesemia-induced seizure-related death. Liu M, et al. Sci Rep, 2023 May 15. PMID 37188671, Free PMC Article
    3. Effect of truncation on TRPM7 channel activity. Xie Z, et al. Channels (Austin), 2023 Dec. PMID 37040321, Free PMC Article
    4. TRPM7 Kinase Domain is Part of the Rac1-SSH2-cofilin Complex Regulating F-actin in the Mouse Nervous System. Chang J, et al. Neurosci Bull, 2023 Jun. PMID 36920646,
    5. Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice. Zhong W, et al. Nat Commun, 2023 Jan 30. PMID 36717580, Free PMC Article

    See all (143) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Essential role of Mg[2+] in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes.
      Title: Essential role of Mg(2+) in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes.
    2. Ischemia-Reperfusion Increases TRPM7 Expression in Mouse Retinas.
      Title: Ischemia-Reperfusion Increases TRPM7 Expression in Mouse Retinas.
    3. TRPM7 kinase activity induces amyloid-beta degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer's disease.
      Title: TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer's disease.
    4. TRPM7 Kinase Domain is Part of the Rac1-SSH2-cofilin Complex Regulating F-actin in the Mouse Nervous System.
      Title: TRPM7 Kinase Domain is Part of the Rac1-SSH2-cofilin Complex Regulating F-actin in the Mouse Nervous System.
    5. TRPM7 kinase mediates hypomagnesemia-induced seizure-related death.
      Title: TRPM7 kinase mediates hypomagnesemia-induced seizure-related death.
    6. Effect of truncation on TRPM7 channel activity.
      Title: Effect of truncation on TRPM7 channel activity.
    7. Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation.
      Title: Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation.
    8. TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.
      Title: TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.
    9. Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice.
      Title: Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice.
    10. TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.
      Title: TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.
    Submit: New GeneRIF Correction See all GeneRIFs (98)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actomyosin structure organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within calcium-dependent cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic cation homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in necroptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in varicosity ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transient receptor potential cation channel subfamily M member 7
    Names
    channel-kinase 1
    long transient receptor potential channel 7
    transient receptor potential M7
    transient receptor potential-phospholipase C-interacting kinase
    transient receptor potential-related protein, ChaK
    NP_001157797.1
    NP_067425.2
    XP_036018328.1
    XP_036018329.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164325.1 → NP_001157797.1  transient receptor potential cation channel subfamily M member 7 isoform 2

      See identical proteins and their annotated locations for NP_001157797.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AL732330
      Consensus CDS
      CCDS50700.1
      UniProtKB/TrEMBL
      A2AI57, B9EK83
      Related
      ENSMUSP00000028843.6, ENSMUST00000028843.12
      Conserved Domains (3) summary
      smart00811
      Location:1595 → 1813
      Alpha_kinase; Alpha-kinase family
      pfam00520
      Location:879 → 1100
      Ion_trans; Ion transport protein
      pfam16519
      Location:1198 → 1249
      TRPM_tetra; Tetramerization domain of TRPM

    2. NM_021450.2 → NP_067425.2  transient receptor potential cation channel subfamily M member 7 isoform 1

      See identical proteins and their annotated locations for NP_067425.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL732330
      Consensus CDS
      CCDS16689.1
      UniProtKB/Swiss-Prot
      A2AI58, Q8C7S7, Q8CE54, Q921Y5, Q923J1, Q925B2, Q9CUT2, Q9JLQ1
      UniProtKB/TrEMBL
      B9EK83
      Related
      ENSMUSP00000099513.4, ENSMUST00000103224.10
      Conserved Domains (3) summary
      smart00811
      Location:1596 → 1814
      Alpha_kinase; Alpha-kinase family
      pfam00520
      Location:879 → 1100
      Ion_trans; Ion transport protein
      pfam16519
      Location:1198 → 1249
      TRPM_tetra; Tetramerization domain of TRPM

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      126633478..126718181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162435.1 → XP_036018328.1  transient receptor potential cation channel subfamily M member 7 isoform X1

      UniProtKB/TrEMBL
      B9EK83
      Conserved Domains (4) summary
      TIGR00870
      Location:663 → 1113
      trp; transient-receptor-potential calcium channel protein
      cd16971
      Location:1519 → 1757
      Alpha_kinase_ChaK1_TRMP7; Alpha-kinase domain of channel kinase 1, also called transient receptor potential cation channel subfamily M member 7
      pfam16519
      Location:1135 → 1188
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:47 → 312
      LSDAT_euk; SLOG in TRPM

    2. XM_036162436.1 → XP_036018329.1  transient receptor potential cation channel subfamily M member 7 isoform X2

      Conserved Domains (3) summary
      TIGR00870
      Location:722 → 1172
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1194 → 1247
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:106 → 371
      LSDAT_euk; SLOG in TRPM

    RNA

    1. XR_001783160.3 RNA Sequence

    2. XR_001783159.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923J1.1 GenPept UniProtKB/Swiss-Prot:Q923J1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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