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    PSG1 pregnancy specific beta-1-glycoprotein 1 [ Homo sapiens (human) ]

    Gene ID: 5669, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PSG1provided by HGNC
    Official Full Name
    pregnancy specific beta-1-glycoprotein 1provided by HGNC
    Primary source
    HGNC:HGNC:9514
    See related
    Ensembl:ENSG00000231924 MIM:176390; AllianceGenome:HGNC:9514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SP1; B1G1; PBG1; CD66f; PSBG1; PSG95; PSGGA; DHFRP2; PSBG-1; PSGIIA; FL-NCA-1/2; PS-beta-C/D; PS-beta-G-1
    Summary
    The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009]
    Expression
    Restricted expression toward placenta (RPKM 224.3) See more
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    Genomic context

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    Location:
    19q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42866464..42879713, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45685415..45698666, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43370616..43383865, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PSG8 antisense RNA 1 Neighboring gene pregnancy specific beta-1-glycoprotein 10, pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 6 Neighboring gene pregnancy specific beta-1-glycoprotein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. High Expression of Pregnancy Specific Beta-1-glycoprotein 1 Is Associated With Poor Gastric Cancer Prognosis. Kang HG, et al. In Vivo, 2022 Nov-Dec. PMID 36309385, Free PMC Article
    2. Effect of Pregnancy Specific β1-Glycoprotein on the Replicative Potential of Naïve T Cells and Immune Memory T Cells. Timganova VP, et al. Bull Exp Biol Med, 2021 Dec. PMID 34855088
    3. Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand. Mendoza M, et al. Glycobiology, 2020 Oct 21. PMID 32280962, Free PMC Article
    4. Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol. He DX, et al. Clin Sci (Lond), 2016 Dec 1. PMID 27653744
    5. Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies. Houston A, et al. MAbs, 2016. PMID 26926266, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Low pregnancy-specific beta-1-glycoprotein is associated with nondipper hypertension and increased risk of preeclampsia in pregnant women with newly diagnosed chronic hypertension.
      Title: Low pregnancy-specific beta-1-glycoprotein is associated with nondipper hypertension and increased risk of preeclampsia in pregnant women with newly diagnosed chronic hypertension.
    2. High Expression of Pregnancy Specific Beta-1-glycoprotein 1 Is Associated With Poor Gastric Cancer Prognosis.
      Title: High Expression of Pregnancy Specific Beta-1-glycoprotein 1 Is Associated With Poor Gastric Cancer Prognosis.
    3. Effect of Pregnancy Specific beta1-Glycoprotein on the Replicative Potential of Naive T Cells and Immune Memory T Cells.
      Title: Effect of Pregnancy Specific β1-Glycoprotein on the Replicative Potential of Naïve T Cells and Immune Memory T Cells.
    4. Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand.
      Title: Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand.
    5. biomarkers suitable for the assessment of chronological ageing were identified, and extrapolated to the context of photo-damaged skin. In particular, KANK4, ACAN, Col XI alpha1, and PSG1, were expressed at an increased level in both chronologically-aged and photo-damaged skin.
      Title: Genome-wide profiling of adult human papillary and reticular fibroblasts identifies ACAN, Col XI α1, and PSG1 as general biomarkers of dermis ageing, and KANK4 as an exemplary effector of papillary fibroblast ageing, related to contractility.
    6. Inhibiting PSG1 can effectively reduce chemoresistance via a transforming growth factor-beta (TGF-beta)-related pathway in ER-negative breast cancer cells.
      Title: Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol.
    7. PSG stimulated IDO activity under the conditions of induction of the monocytes by interferon-gamma.
      Title: Effect of pregnancy-specific β1-glycoprotein on indoleamine-2,3-dioxygenase activity in human monocytes.
    8. Under conditions of directed induction of phenotypic changes in CD4(+) lymphocytes to regulatory T cells (Treg), pregnancy-specific at high concentrations (10 and 100 mug/mL) increased FOXP3 expression. The evaluation of the spontaneous expression level of FOXP3 mRNA showed that pregnancy-specific beta1-glycoprotein (1 and 100 mug/mL) stimulated the expression of this factor in mononuclear cells and isolated CD4(+) lym...
      Title: The effect of pregnancy-specific β1-glycoprotein 1 on the transcription factor FOXP3 expression by immunocompetent cells.
    9. results identify a non-placental site of PSG expression in the gut and associated tumors, with implications for determining whether PSGs have a role in tumor progression, and utility as tumor biomarkers.
      Title: Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies.
    10. the presence of GAGs on the surface of endothelial cells was required for the ability of PSG1 to induce tube formation
      Title: Pregnancy-specific glycoprotein 1 induces endothelial tubulogenesis through interaction with cell surface proteoglycans.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ90598, FLJ90654

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pregnancy-specific beta-1-glycoprotein 1
    Names
    CD66 antigen-like family member F
    fetal liver non-specific cross-reactive antigen 1/2
    pregnancy-specific B-1 glycoprotein
    pregnancy-specific beta-1 glycoprotein C/D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001184825.2 → NP_001171754.1  pregnancy-specific beta-1-glycoprotein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001171754.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, compared to variant 4. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 4.
      Source sequence(s)
      AC005238
      Consensus CDS
      CCDS54275.1
      UniProtKB/Swiss-Prot
      O75236, P11462, P11463, P11464, Q15231, Q15241, Q15243, Q16660, Q6ICR4, Q9P1W5, Q9UQ79
      UniProtKB/TrEMBL
      Q96QL5
      Related
      ENSP00000413041.2, ENST00000436291.7
      Conserved Domains (3) summary
      pfam13895
      Location:335 → 413
      Ig_2; Immunoglobulin domain
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:148 → 236
      Ig; Immunoglobulin domain

    2. NM_001184826.2 → NP_001171755.1  pregnancy-specific beta-1-glycoprotein 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001171755.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon, compared to variant 4. It encodes isoform 3, which has a shorter and distinct C-terminus, compared to isoform 4.
      Source sequence(s)
      AC005238
      Consensus CDS
      CCDS59392.1
      UniProtKB/TrEMBL
      Q96QL5
      Related
      ENSP00000472610.1, ENST00000595356.5
      Conserved Domains (4) summary
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:339 → 413
      IG_like; Immunoglobulin like
      pfam13895
      Location:335 → 413
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148 → 236
      Ig; Immunoglobulin domain

    3. NM_001297773.2 → NP_001284702.1  pregnancy-specific beta-1-glycoprotein 1 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001284702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AC005238, M20879
      Consensus CDS
      CCDS74380.1
      UniProtKB/TrEMBL
      Q96QL5
      Related
      ENSP00000308970.6, ENST00000312439.10
      Conserved Domains (4) summary
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:339 → 413
      IG_like; Immunoglobulin like
      pfam13895
      Location:335 → 413
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148 → 236
      Ig; Immunoglobulin domain

    4. NM_001330524.2 → NP_001317453.1  pregnancy-specific beta-1-glycoprotein 1 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC005238, DA829309
      Consensus CDS
      CCDS82360.1
      UniProtKB/TrEMBL
      G5E9F7, Q8NC17
      Related
      ENSP00000385386.3, ENST00000403380.7
      Conserved Domains (4) summary
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246 → 320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242 → 320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148 → 236
      Ig; Immunoglobulin domain

    5. NM_006905.3 → NP_008836.2  pregnancy-specific beta-1-glycoprotein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_008836.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses alternate splice sites in the 3' terminal exon, compared to variant 4. It encodes isoform 1, which has a shorter and distinct C-terminus, compared to isoform 4.
      Source sequence(s)
      AC005238, BC022338
      Consensus CDS
      CCDS12612.1
      UniProtKB/TrEMBL
      Q96QL5
      Related
      ENSP00000244296.2, ENST00000244296.6
      Conserved Domains (4) summary
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:339 → 413
      IG_like; Immunoglobulin like
      pfam13895
      Location:335 → 413
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148 → 236
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      42866464..42879713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259065.4 → XP_005259122.1  pregnancy-specific beta-1-glycoprotein 1 isoform X1

      UniProtKB/TrEMBL
      Q8NC17
      Conserved Domains (4) summary
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246 → 320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242 → 320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148 → 236
      Ig; Immunoglobulin domain

    2. XM_011527125.2 → XP_011525427.1  pregnancy-specific beta-1-glycoprotein 1 isoform X2

      See identical proteins and their annotated locations for XP_011525427.1

      UniProtKB/TrEMBL
      O75238, Q9UPK8
      Conserved Domains (4) summary
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246 → 320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242 → 320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148 → 236
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      45685415..45698666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321485.1 → XP_054177460.1  pregnancy-specific beta-1-glycoprotein 1 isoform X1

    2. XM_054321486.1 → XP_054177461.1  pregnancy-specific beta-1-glycoprotein 1 isoform X2

      UniProtKB/TrEMBL
      O75238
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11464.1 GenPept UniProtKB/Swiss-Prot:P11464

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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