Rcan1 regulator of calcineurin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rcan1provided by MGI
Official Full Name: regulator of calcineurin 1provided by MGI
Primary source: MGI:MGI:1890564
See related: Ensembl:ENSMUSG00000022951 AllianceGenome:MGI:1890564
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CSP1; DSC1; RCN1; Dscr1; MCIP1; CALP1L; Adapt78
Summary: Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity and identical protein binding activity. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; response to ischemia; and short-term memory. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human RCAN1 (regulator of calcineurin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 17.8), heart adult (RPKM 14.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 53.6 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (92188839..92263057, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (92391951..92466169, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mice with double knockout of Egr-1 and RCAN1 exhibit reduced inflammation during Pseudomonas aeruginosa lung infection.
Title: Mice with double knockout of Egr-1 and RCAN1 exhibit reduced inflammation during Pseudomonas aeruginosa lung infection.
DSCR1 deficiency ameliorates the Abeta pathology of Alzheimer's disease by enhancing microglial activity.
Title: DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer's disease by enhancing microglial activity.
Upregulation of RCAN1.4 by HIF1alpha alleviates OGD-induced inflammatory response in astrocytes.
Title: Upregulation of RCAN1.4 by HIF1α alleviates OGD-induced inflammatory response in astrocytes.
RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging.
Title: RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging.
Down Syndrome Candidate Region 1 Isoform 1L regulated tumor growth by targeting both angiogenesis and tumor cells.
Title: Down Syndrome Candidate Region 1 Isoform 1L regulated tumor growth by targeting both angiogenesis and tumor cells.
DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer's disease.
Title: DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer's disease.
Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression.
Title: Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression.
Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background.
Title: Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background.
Obesity-Induced Regulator of Calcineurin 1 Overexpression Leads to beta-Cell Failure Through Mitophagy Pathway Inhibition.
Title: Obesity-Induced Regulator of Calcineurin 1 Overexpression Leads to β-Cell Failure Through Mitophagy Pathway Inhibition.
Down Syndrome Critical Region 1 Reduces Oxidative Stress-Induced Retinal Ganglion Cells Apoptosis via CREB-Bcl-2 Pathway.
Title: Down Syndrome Critical Region 1 Reduces Oxidative Stress-Induced Retinal Ganglion Cells Apoptosis via CREB-Bcl-2 Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (76)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rcan1 (e-PCR), detects polymorphism
- UniSTS:259072

RH125551 (e-PCR)
- UniSTS:162365

Rcan1 (e-PCR), detects polymorphism
- UniSTS:259392

RH124780 (e-PCR)
- UniSTS:161602

AI429645 (e-PCR)
- UniSTS:160593

Rcan1 (e-PCR), detects polymorphism
- UniSTS:499085

Dscr1 (e-PCR), detects polymorphism
- UniSTS:186515

RH130128 (e-PCR)
- UniSTS:213416

AV028423 (e-PCR)
- UniSTS:180945

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcineurin-NFAT signaling cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within locomotion involved in locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within short-term memory	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcipressin-1

Names: calcineurin inhibitor; down syndrome critical region protein 1 homolog; myocyte-enriched calcineurin-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081549.2 → NP_001075018.1 calcipressin-1 isoform 1

See identical proteins and their annotated locations for NP_001075018.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK146764, BY276032, BY454038

Consensus CDS

CCDS37405.1

UniProtKB/Swiss-Prot

Q7TNY3, Q91WQ4, Q9JHG6, Q9JK50, Q9JK51, Q9JKK2, Q9JKK3

Related

ENSMUSP00000060394.9, ENSMUST00000060005.15

Conserved Domains (1) summary

pfam04847
Location:75 → 244

Calcipressin; Calcipressin
NM_019466.4 → NP_062339.2 calcipressin-1 isoform 2

See identical proteins and their annotated locations for NP_062339.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC162305, AK077283, AK146764, BY454038

Consensus CDS

CCDS28337.1

UniProtKB/TrEMBL

Q542V6

Related

ENSMUSP00000023672.8, ENSMUST00000023672.10

Conserved Domains (1) summary

pfam04847
Location:22 → 191

Calcipressin; Calcipressin