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    NEDD8 NEDD8 ubiquitin like modifier [ Homo sapiens (human) ]

    Gene ID: 4738, updated on 31-Mar-2024

    Summary

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    Official Symbol
    NEDD8provided by HGNC
    Official Full Name
    NEDD8 ubiquitin like modifierprovided by HGNC
    Primary source
    HGNC:HGNC:7732
    See related
    Ensembl:ENSG00000129559 MIM:603171; AllianceGenome:HGNC:7732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEDD-8
    Summary
    Enables ubiquitin protein ligase binding activity. Acts upstream of or within protein neddylation. Located in cytosol and nucleoplasm. Biomarker of Parkinson's disease and malignant astrocytoma. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in fat (RPKM 81.8), kidney (RPKM 81.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    14q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24216857..24232367, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18415233..18430739, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24686063..24701573, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 4A Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24682177-24682985 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24683998-24684736 Neighboring gene NEDD8-MDP1 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8198 Neighboring gene magnesium dependent phosphatase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24701437-24702302 Neighboring gene guanosine monophosphate reductase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24710068-24710597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8200 Neighboring gene TERF1 interacting nuclear factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Blocking neddylation elicits antiviral effect against hepatitis B virus replication. Abounouh K, et al. Mol Biol Rep, 2022 Jan. PMID 34716866
    2. Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation. Lobato-Gil S, et al. Cell Rep, 2021 Jan 19. PMID 33472076
    3. Promotion of tumor-associated macrophages infiltration by elevated neddylation pathway via NF-κB-CCL2 signaling in lung cancer. Zhou L, et al. Oncogene, 2019 Jul. PMID 31243299
    4. Neural precursor cell expressed, developmentally downregulated 8 promotes tumor progression and predicts poor prognosis of patients with bladder cancer. Tian DW, et al. Cancer Sci, 2019 Jan. PMID 30407690, Free PMC Article
    5. Distinct outcomes of CRL-Nedd8 pathway inhibition reveal cancer cell plasticity. Rulina AV, et al. Cell Death Dis, 2016 Dec 1. PMID 27906189, Free PMC Article

    See all (262) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review).
      Title: Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review).
    2. [Differential expression of NEDD8 in different pathological types of chronic rhinosinusitis with nasal polyps].
      Title: [Differential expression of NEDD8 in different pathological types of chronic rhinosinusitis with nasal polyps].
    3. Blocking neddylation elicits antiviral effect against hepatitis B virus replication.
      Title: Blocking neddylation elicits antiviral effect against hepatitis B virus replication.
    4. The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.
      Title: The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.
    5. The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage.
      Title: The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage.
    6. A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1).
      Title: A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1).
    7. Map of ubiquitin-like post-translational modifications in chronic lymphocytic leukemia. Role of p53 lysine 120 NEDDylation.
      Title: Map of ubiquitin-like post-translational modifications in chronic lymphocytic leukemia. Role of p53 lysine 120 NEDDylation.
    8. Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.
      Title: Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.
    9. Structural and functional consequences of NEDD8 phosphorylation.
      Title: Structural and functional consequences of NEDD8 phosphorylation.
    10. TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia.
      Title: TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia.
    Submit: New GeneRIF Correction See all GeneRIFs (114)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 complexes with NEDD8 PubMed
    vif HIV-1 Vif recruits an active ubiquitin ligase complex composed of Elongin B/C, Cullin5, Nedd8, and Rbx1, which mediates polyubiquitylation of APOBEC3G PubMed
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ43224, MGC104393, MGC125896, MGC125897

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein neddylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NEDD8
    Names
    neddylin
    neural precursor cell expressed, developmentally down-regulated 8
    ubiquitin-like protein Nedd8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006156.3 → NP_006147.1  NEDD8

      See identical proteins and their annotated locations for NP_006147.1

      Status: VALIDATED

      Source sequence(s)
      BC104200, BE548741, CF130271
      Consensus CDS
      CCDS9621.1
      UniProtKB/Swiss-Prot
      Q15843, Q3SXN8, Q6LES6
      Related
      ENSP00000250495.5, ENST00000250495.10
      Conserved Domains (1) summary
      cd01806
      Location:3 → 76
      Ubl_NEDD8; ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      24216857..24232367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654722.1 Reference GRCh38.p14 PATCHES

      Range
      517835..533345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      18415233..18430739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15843.1 GenPept UniProtKB/Swiss-Prot:Q15843

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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