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    MT1E metallothionein 1E [ Homo sapiens (human) ]

    Gene ID: 4493, updated on 7-Apr-2024

    Summary

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    Official Symbol
    MT1Eprovided by HGNC
    Official Full Name
    metallothionein 1Eprovided by HGNC
    Primary source
    HGNC:HGNC:7397
    See related
    Ensembl:ENSG00000169715 MIM:156351; AllianceGenome:HGNC:7397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MT1; MTD; MT-1E; MT-IE
    Summary
    Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver (RPKM 106.4), small intestine (RPKM 103.9) and 20 other tissues See more
    Orthologs
    all
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    Genomic context

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    See MT1E in Genome Data Viewer
    Location:
    16q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (56625781..56627112)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62420746..62422077)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56659693..56661024)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7511 Neighboring gene metallothionein 2A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:56651076-56651609 Neighboring gene metallothionein 1L (pseudogene) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:56659379-56659915 Neighboring gene metallothionein 1M Neighboring gene metallothionein 1J, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of MT1E as a novel tumor suppressor in hepatocellular carcinoma. Liu Q, et al. Pathol Res Pract, 2020 Nov. PMID 32956919
    2. Role of metallothionein 1E in the migration and invasion of human glioma cell lines. Ryu HH, et al. Int J Oncol, 2012 Oct. PMID 22843066
    3. Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis. Faller WJ, et al. Melanoma Res, 2010 Oct. PMID 20848733
    4. Epigenetic alteration of the metallothionein 1E gene in human endometrial carcinomas. Tse KY, et al. Tumour Biol, 2009. PMID 19420986
    5. Metallothionein isoform 1 and 2 gene expression in a human urothelial cell line (UROtsa) exposed to CdCl2 and NaAsO2. Sens D, et al. J Toxicol Environ Health A, 2003 Nov 14. PMID 14555400

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rare Variant in Metallothionein 1E Increases the Risk of Type 2 Diabetes in a Chinese Population.
      Title: Rare Variant in Metallothionein 1E Increases the Risk of Type 2 Diabetes in a Chinese Population.
    2. Identification of MT1E as a novel tumor suppressor in hepatocellular carcinoma.
      Title: Identification of MT1E as a novel tumor suppressor in hepatocellular carcinoma.
    3. Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival.
      Title: Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival.
    4. In clear cell renal cell carcinoma (RCC) MT1E, MT1G and MT1M expression was higher than that noted in other histological tumor subtypes (all P<0.0500). In addition, some associations were observed between metabolic syndromerelated clinical parameters and promoter methylation or gene expression
      Title: DNA methylation of metallothionein genes is associated with the clinical features of renal cell carcinoma.
    5. Forced MT1E expression rescues both hypersensitivity of CDKAL1 mutant cells to glycolipotoxicity and pancreatic beta-cell dysfunction in vitro and in vivo.
      Title: Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E.
    6. MT1E can enhance the migration and invasion of human glioma cells by inducing MMP-9 inactivation via the upregulation of NF-kappaB p50.
      Title: Role of metallothionein 1E in the migration and invasion of human glioma cell lines.
    7. Our results reveal that menopause influences the adipose tissue expression of many genes, especially of neurexin 3, metallothionein 1E, and keratyn 7, which are associated with the alteration of several key biological processes.
      Title: Profile of adipose tissue gene expression in premenopausal and postmenopausal women: site-specific differences.
    8. MT1E is a potential tumour suppressor gene, whose loss may promote resistance to apoptosis-inducing therapies.
      Title: Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis.
    9. Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia.
      Title: Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.
    10. High frequency of hypermethylation of MT-1E was found in endometrial carcinomas.
      Title: Epigenetic alteration of the metallothionein 1E gene in human endometrial carcinomas.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cadmium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to copper ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in detoxification of copper ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metallothionein-1E
    Names
    metallothionein 1E (functional)
    metallothionein D
    metallothionein-IE

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363555.2 → NP_001350484.1  metallothionein-1E isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF495759, BC131609
      Consensus CDS
      CCDS86530.1
      Related
      ENSP00000328137.6, ENST00000330439.7
      Conserved Domains (1) summary
      cl19543
      Location:4 → 35
      Metallothio; Metallothionein

    2. NM_175617.4 → NP_783316.2  metallothionein-1E isoform 2

      See identical proteins and their annotated locations for NP_783316.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses alternate splice sites in the 3' coding region compared to variant 1, resulting in a frameshift. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC009699
      Consensus CDS
      CCDS10764.2
      UniProtKB/Swiss-Prot
      A2RRF7, P04732, Q86YX4, Q8TD51
      Related
      ENSP00000307706.5, ENST00000306061.10
      Conserved Domains (1) summary
      pfam00131
      Location:4 → 61
      Metallothio; Metallothionein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      56625781..56627112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      62420746..62422077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04732.1 GenPept UniProtKB/Swiss-Prot:P04732

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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