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    ITGAM integrin subunit alpha M [ Ovis aries (sheep) ]

    Gene ID: 443217, updated on 5-Mar-2024

    Summary

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    Gene symbol
    ITGAM
    Gene description
    integrin subunit alpha M
    See related
    EnsemblRapid:ENSOARG00020024053
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Also known as
    CR3; C3bi; CD11B
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See ITGAM in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 24 NC_056077.1 (27864242..27907445)

    Chromosome 24 - NC_056077.1Genomic Context describing neighboring genes Neighboring gene apoptosis-associated speck-like protein containing a CARD Neighboring gene tripartite motif containing 72 Neighboring gene uncharacterized LOC121817906 Neighboring gene integrin subunit alpha X

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056077.1 Chromosome 24 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane ruffles capture C3bi-opsonized particles in activated macrophages. Patel PC, et al. Mol Biol Cell, 2008 Nov. PMID 18768756, Free PMC Article
    2. CD11b of Ovis canadensis and Ovis aries: molecular cloning and characterization. Lawrence PK, et al. Vet Immunol Immunopathol, 2007 Oct 15. PMID 17628696

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrin alpha-M
    Names
    complement receptor 3
    leukocyte integrin alpha M

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082593.1 → NP_001076062.1  integrin alpha-M precursor

      See identical proteins and their annotated locations for NP_001076062.1

      Status: PROVISIONAL

      Source sequence(s)
      EF206308
      UniProtKB/TrEMBL
      A0A6P3CWR3, A0A835ZQ45, A2TJJ2
      Related
      ENSOARP00020031268.1, ENSOART00020037754.2
      Conserved Domains (4) summary
      smart00191
      Location:516 → 571
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:149 → 324
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1129 → 1143
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:614 → 925
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056077.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      27864242..27907445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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