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    Mpv17 mitochondrial inner membrane protein MPV17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360463, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Mpv17provided by RGD
    Official Full Name
    mitochondrial inner membrane protein MPV17provided by RGD
    Primary source
    RGD:1310512
    See related
    Ensembl:ENSRNOG00000049430 AllianceGenome:RGD:1310512
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mpv17l
    Summary
    Predicted to enable channel activity. Predicted to be involved in several processes, including cellular response to reactive oxygen species; glomerular basement membrane development; and regulation of mitochondrial DNA metabolic process. Predicted to act upstream of or within reactive oxygen species metabolic process and sensory perception of sound. Predicted to be located in mitochondrial inner membrane and peroxisome. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2EE and mitochondrial DNA depletion syndrome 6. Orthologous to human MPV17 (mitochondrial inner membrane protein MPV17). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 47.0), Thymus (RPKM 41.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mpv17 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (30941693..30956389)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25221668..25236241)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26585713..26600265)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2B subunit delta Neighboring gene general transcription factor IIIC subunit 2 Neighboring gene tripartite motif-containing 54 Neighboring gene urocortin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Increased Expression of Mitochondrial Inner-Membrane Protein Mpv17 After Intracerebral Hemorrhage in Adult Rats. Li A, et al. Neurochem Res, 2015 Aug. PMID 26123482
    2. MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria. Dalla Rosa I, et al. PLoS Genet, 2016 Jan. PMID 26760297, Free PMC Article
    3. The Human Mitochondrial DNA Depletion Syndrome Gene MPV17 Encodes a Non-selective Channel That Modulates Membrane Potential. Antonenkov VD, et al. J Biol Chem, 2015 May 29. PMID 25861990, Free PMC Article
    4. MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion. Spinazzola A, et al. Nat Genet, 2006 May. PMID 16582910
    5. The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species. Zwacka RM, et al. EMBO J, 1994 Nov 1. PMID 7957077, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mpv17 expression was increased after intracerebral hemorrhage.
      Title: Increased Expression of Mitochondrial Inner-Membrane Protein Mpv17 After Intracerebral Hemorrhage in Adult Rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glomerular basement membrane development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homeostatic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homeostatic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner ear development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial genome maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial genome maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial DNA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrial DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial DNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein Mpv17
    Names
    MPV17 mitochondrial membrane protein-like
    MpV17 mitochondrial inner membrane protein
    Mpv17 transgene, kidney disease mutant-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098240.1 → NP_001091710.1  protein Mpv17

      See identical proteins and their annotated locations for NP_001091710.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091193
      UniProtKB/Swiss-Prot
      Q5BK62
      UniProtKB/TrEMBL
      A0A8I6ADY6, A6HA73
      Conserved Domains (1) summary
      pfam04117
      Location:109 → 170
      Mpv17_PMP22; Mpv17 / PMP22 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      30941693..30956389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112437.2 → XP_038968365.1  protein Mpv17 isoform X1

      Conserved Domains (1) summary
      pfam04117
      Location:140 → 201
      Mpv17_PMP22; Mpv17 / PMP22 family

    2. XM_039112438.2 → XP_038968366.1  protein Mpv17 isoform X2

      Conserved Domains (1) summary
      pfam04117
      Location:140 → 190
      Mpv17_PMP22; Mpv17 / PMP22 family

    3. XM_063262038.1 → XP_063118108.1  protein Mpv17 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GJS1

    4. XM_063262042.1 → XP_063118112.1  protein Mpv17 isoform X8

    5. XM_039112445.2 → XP_038968373.1  protein Mpv17 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ADY6, A0A8I6GJS1
      Related
      ENSRNOP00000091585.1
      Conserved Domains (1) summary
      pfam04117
      Location:109 → 159
      Mpv17_PMP22; Mpv17 / PMP22 family

    6. XM_039112444.2 → XP_038968372.1  protein Mpv17 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ADY6, A0A8I6GJS1
      Conserved Domains (1) summary
      pfam04117
      Location:109 → 159
      Mpv17_PMP22; Mpv17 / PMP22 family

    7. XM_063262040.1 → XP_063118110.1  protein Mpv17 isoform X6

    8. XM_063262039.1 → XP_063118109.1  protein Mpv17 isoform X6

    9. XM_039112443.2 → XP_038968371.1  protein Mpv17 isoform X4

      UniProtKB/Swiss-Prot
      Q5BK62
      UniProtKB/TrEMBL
      A0A8I6ADY6, A6HA73
      Related
      ENSRNOP00000092589.1
      Conserved Domains (1) summary
      pfam04117
      Location:109 → 170
      Mpv17_PMP22; Mpv17 / PMP22 family

    10. XM_039112441.2 → XP_038968369.1  protein Mpv17 isoform X4

      UniProtKB/Swiss-Prot
      Q5BK62
      UniProtKB/TrEMBL
      A0A8I6ADY6, A6HA73
      Conserved Domains (1) summary
      pfam04117
      Location:109 → 170
      Mpv17_PMP22; Mpv17 / PMP22 family

    11. XM_063262043.1 → XP_063118113.1  protein Mpv17 isoform X9

    12. XM_063262041.1 → XP_063118111.1  protein Mpv17 isoform X7

    13. XM_039112440.2 → XP_038968368.1  protein Mpv17 isoform X4

      UniProtKB/Swiss-Prot
      Q5BK62
      UniProtKB/TrEMBL
      A0A8I6ADY6, A6HA73
      Related
      ENSRNOP00000079234.1
      Conserved Domains (1) summary
      pfam04117
      Location:109 → 170
      Mpv17_PMP22; Mpv17 / PMP22 family

    14. XM_039112439.2 → XP_038968367.1  protein Mpv17 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ADY6
      Conserved Domains (1) summary
      pfam04117
      Location:111 → 172
      Mpv17_PMP22; Mpv17 / PMP22 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK62.1 GenPept UniProtKB/Swiss-Prot:Q5BK62

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