STOML2 stomatin like 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STOML2provided by HGNC
Official Full Name: stomatin like 2provided by HGNC
Primary source: HGNC:HGNC:14559
See related: Ensembl:ENSG00000165283 MIM:608292; AllianceGenome:HGNC:14559
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SLP-2; HSPC108
Summary: Enables GTPase binding activity and cardiolipin binding activity. Involved in several processes, including inorganic cation transmembrane transport; positive regulation of cardiolipin metabolic process; and positive regulation of mitochondrial DNA replication. Located in membrane raft; mitochondrial inner membrane; and mitochondrial intermembrane space. Is extrinsic component of plasma membrane. Colocalizes with several cellular components, including COP9 signalosome; T cell receptor complex; and immunological synapse. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney (RPKM 27.8), heart (RPKM 26.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9p13.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (35099776..35103195, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (35118954..35122373, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (35099773..35103192, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma.
Title: Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma.
Overexpressing lipid raft protein STOML2 modulates the tumor microenvironment via NF-kappaB signaling in colorectal cancer.
Title: Overexpressing lipid raft protein STOML2 modulates the tumor microenvironment via NF-κB signaling in colorectal cancer.
STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing PARL-induced PINK1 degradation.
Title: STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing PARL-induced PINK1 degradation.
CHCHD10 and SLP2 control the stability of the PHB complex: a key factor for motor neuron viability.
Title: CHCHD10 and SLP2 control the stability of the PHB complex: a key factor for motor neuron viability.
Characterization of the interactome of c-Src within the mitochondrial matrix by proximity-dependent biotin identification.
Title: Characterization of the interactome of c-Src within the mitochondrial matrix by proximity-dependent biotin identification.
Stomatinlike protein 2 induces metastasis by regulating the expression of a ratelimiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer.
Title: Stomatin‑like protein 2 induces metastasis by regulating the expression of a rate‑limiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer.
Stomatin-Like Protein-2: A Potential Target to Treat Mitochondrial Cardiomyopathy.
Title: Stomatin-Like Protein-2: A Potential Target to Treat Mitochondrial Cardiomyopathy.
Stomatin-like protein 2 (SLP2) regulates the proliferation and invasion of trophoblast cells by modulating mitochondrial functions.
Title: Stomatin-like protein 2 (SLP2) regulates the proliferation and invasion of trophoblast cells by modulating mitochondrial functions.
STOML2 potentiates metastasis of hepatocellular carcinoma by promoting PINK1-mediated mitophagy and regulates sensitivity to lenvatinib.
Title: STOML2 potentiates metastasis of hepatocellular carcinoma by promoting PINK1-mediated mitophagy and regulates sensitivity to lenvatinib.
Clinical significance of SLP-2 in epithelial ovarian cancer and its regulatory effect on the Notch signaling pathway.
Title: Clinical significance of SLP-2 in epithelial ovarian cancer and its regulatory effect on the Notch signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of stomatin (EPB72)-like 2 (SLP-2) in umbilical cord blood mononuclear cells and T-cell lines	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 is identified to have a physical interaction with stomatin (EPB72)-like 2 (STOML2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of stomatin (EPB72)-like 2 (STOML2) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78365 (e-PCR)
- UniSTS:13352

G20553 (e-PCR)
- UniSTS:35389

A005W26 (e-PCR)
- UniSTS:35390

A002P16 (e-PCR)
- UniSTS:43594

RH41785 (e-PCR)
- UniSTS:12941

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables T cell receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables cardiolipin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in CD4-positive, alpha-beta T cell activation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-2 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein complex oligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in proton motive force-driven mitochondrial ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in stress-induced mitochondrial fusion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: stomatin-like protein 2, mitochondrial

Names: EPB72-like 2; EPB72-like protein 2; paraprotein target 7; paratarg-7; stomatin (EPB72)-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001287031.2 → NP_001273960.1 stomatin-like protein 2, mitochondrial isoform b

See identical proteins and their annotated locations for NP_001273960.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AA657517, AK303883, AW273545, HY367065

Consensus CDS

CCDS69588.1

UniProtKB/Swiss-Prot

Q9UJZ1

Related

ENSP00000395743.2, ENST00000452248.6

Conserved Domains (2) summary

COG0330
Location:41 → 269

HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]

cd08829
Location:74 → 147

SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001287032.1 → NP_001273961.1 stomatin-like protein 2, mitochondrial isoform c

See identical proteins and their annotated locations for NP_001273961.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AA657517, AF190167, AW273545, BQ935988, BX400542, HY039403, HY367065

UniProtKB/Swiss-Prot

Q9UJZ1

Conserved Domains (3) summary

COG0330
Location:2 → 263

HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]

cd08829
Location:23 → 133

SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

pfam16200
Location:208 → 270

Band_7_C; C-terminal region of band_7
NM_001287033.2 → NP_001273962.1 stomatin-like protein 2, mitochondrial isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.

Source sequence(s)

AA657517, AW273545, BU528995, HY039403, HY367065

Consensus CDS

CCDS75830.1

UniProtKB/TrEMBL

A0A087WYB4

Related

ENSP00000481672.1, ENST00000619795.4

Conserved Domains (2) summary

COG0330
Location:4 → 268

HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]

cd08829
Location:28 → 138

SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_013442.3 → NP_038470.1 stomatin-like protein 2, mitochondrial isoform a

See identical proteins and their annotated locations for NP_038470.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AA657517, AF190167, AW273545, HY367065

Consensus CDS

CCDS6577.1

UniProtKB/Swiss-Prot

B4E1K7, D3DRN3, O60376, Q53G29, Q96FY2, Q9P042, Q9UJZ1

Related

ENSP00000348886.5, ENST00000356493.10

Conserved Domains (2) summary

COG0330
Location:41 → 314

HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]

cd08829
Location:74 → 184

SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily