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    Fip1l1 factor interacting with PAPOLA and CPSF1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289582, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Fip1l1provided by RGD
    Official Full Name
    factor interacting with PAPOLA and CPSF1provided by RGD
    Primary source
    RGD:1309336
    See related
    Ensembl:ENSRNOG00000002275 AllianceGenome:RGD:1309336
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to contribute to RNA binding activity. Predicted to be involved in mRNA polyadenylation and pre-mRNA cleavage required for polyadenylation. Predicted to be located in nucleoplasm. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human FIP1L1 (factor interacting with PAPOLA and CPSF1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 147.7), Adrenal (RPKM 147.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    14p11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (33969341..34030871, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (33615210..33675742, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (36150381..36208395, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481742 Neighboring gene uncharacterized LOC134481839 Neighboring gene ligand of numb-protein X 1 Neighboring gene sec1 family domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene RAS-like family 11 member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. [Characteristics of cytogenetics and molecular biology in patients with eosinophilia]. Qu SQ, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2012 Oct. PMID 23114151
    2. Response to imatinib mesylate in patients with hypereosinophilic syndrome. Arefi M, et al. Int J Hematol, 2012 Sep. PMID 22806436
    3. Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation. Kiefer H, et al. J Biol Chem, 2009 Apr 17. PMID 19224921, Free PMC Article
    4. Pre-mRNA 3'-end processing complex assembly and function. Chan S, et al. Wiley Interdiscip Rev RNA, 2011 May-Jun. PMID 21957020, Free PMC Article
    5. Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors. Gruber AR, et al. Wiley Interdiscip Rev RNA, 2014 Mar-Apr. PMID 24243805, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93674

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA 3'-end-processing factor FIP1
    Names
    FIP1-like 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008295.1 → NP_001008296.1  pre-mRNA 3'-end-processing factor FIP1

      See identical proteins and their annotated locations for NP_001008296.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085767
      UniProtKB/Swiss-Prot
      Q5U317
      UniProtKB/TrEMBL
      B6RIU0
      Conserved Domains (1) summary
      pfam05182
      Location:153 → 195
      Fip1; Fip1 motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      33969341..34030871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272907.1 → XP_063128977.1  pre-mRNA 3'-end-processing factor FIP1 isoform X12

    2. XM_063272909.1 → XP_063128979.1  pre-mRNA 3'-end-processing factor FIP1 isoform X14

    3. XM_039091689.2 → XP_038947617.1  pre-mRNA 3'-end-processing factor FIP1 isoform X11

      Related
      ENSRNOP00000083703.1
      Conserved Domains (1) summary
      pfam05182
      Location:153 → 195
      Fip1; Fip1 motif

    4. XM_006250887.5 → XP_006250949.1  pre-mRNA 3'-end-processing factor FIP1 isoform X9

      See identical proteins and their annotated locations for XP_006250949.1

      Conserved Domains (1) summary
      pfam05182
      Location:153 → 195
      Fip1; Fip1 motif

    5. XM_039091686.2 → XP_038947614.1  pre-mRNA 3'-end-processing factor FIP1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZW26
      Related
      ENSRNOP00000082160.1
      Conserved Domains (1) summary
      pfam05182
      Location:153 → 195
      Fip1; Fip1 motif

    6. XM_063272906.1 → XP_063128976.1  pre-mRNA 3'-end-processing factor FIP1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZXH8

    7. XM_063272908.1 → XP_063128978.1  pre-mRNA 3'-end-processing factor FIP1 isoform X13

    8. XM_006250884.5 → XP_006250946.1  pre-mRNA 3'-end-processing factor FIP1 isoform X3

      See identical proteins and their annotated locations for XP_006250946.1

      UniProtKB/TrEMBL
      A0A0G2K376
      Related
      ENSRNOP00000072529.1
      Conserved Domains (1) summary
      pfam05182
      Location:153 → 195
      Fip1; Fip1 motif

    9. XM_039091687.2 → XP_038947615.1  pre-mRNA 3'-end-processing factor FIP1 isoform X6

      Conserved Domains (1) summary
      pfam05182
      Location:153 → 195
      Fip1; Fip1 motif

    10. XM_006250885.5 → XP_006250947.1  pre-mRNA 3'-end-processing factor FIP1 isoform X5

      See identical proteins and their annotated locations for XP_006250947.1

      UniProtKB/TrEMBL
      A0A8L2QNW1
      Related
      ENSRNOP00000049728.3
      Conserved Domains (1) summary
      pfam05182
      Location:153 → 195
      Fip1; Fip1 motif

    11. XM_039091688.2 → XP_038947616.1  pre-mRNA 3'-end-processing factor FIP1 isoform X8

      Conserved Domains (1) summary
      pfam05182
      Location:153 → 195
      Fip1; Fip1 motif

    12. XM_006250883.5 → XP_006250945.1  pre-mRNA 3'-end-processing factor FIP1 isoform X2

      See identical proteins and their annotated locations for XP_006250945.1

      Conserved Domains (1) summary
      pfam05182
      Location:153 → 195
      Fip1; Fip1 motif

    13. XM_006250886.5 → XP_006250948.1  pre-mRNA 3'-end-processing factor FIP1 isoform X7

      Conserved Domains (1) summary
      pfam05182
      Location:153 → 195
      Fip1; Fip1 motif

    14. XM_006250882.5 → XP_006250944.1  pre-mRNA 3'-end-processing factor FIP1 isoform X1

      See identical proteins and their annotated locations for XP_006250944.1

      UniProtKB/TrEMBL
      A0A8I6A5J2
      Related
      ENSRNOP00000088121.1
      Conserved Domains (1) summary
      pfam05182
      Location:153 → 195
      Fip1; Fip1 motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U317.1 GenPept UniProtKB/Swiss-Prot:Q5U317

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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