Kif19a kinesin family member 19A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif19aprovided by MGI
Official Full Name: kinesin family member 19Aprovided by MGI
Primary source: MGI:MGI:2447024
See related: Ensembl:ENSMUSG00000010021 AllianceGenome:MGI:2447024
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kif19
Summary: Enables plus-end-directed microtubule motor activity. Involved in axonemal microtubule depolymerization and plus-end specific microtubule depolymerization. Located in cilium. Orthologous to human KIF19 (kinesin family member 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 6.6), testis adult (RPKM 4.2) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.44 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (114656227..114681565)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (114764970..114791166)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals.
Title: AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals.
Result showed that overexpression of Oocyte-G1 increased apoptosis in cultured cells. Oocyte-G1 transgenic mice also showed an increased apoptotic rate in male germ cells. Co-localization experiments revealed an interaction between Oocyte-G1 and Caspase-3 and suggest that Oocyte-G1 may promote male germ cell apoptosis through activating Caspase-3.
Title: Oocyte-G1 promotes male germ cell apoptosis through activation of Caspase-3.
findings suggest that KIF19A, a member of the kinesin superfamily, regulates ciliary length by depolymerizing microtubules at the tips of cilia
Title: KIF19A is a microtubule-depolymerizing kinesin for ciliary length control.
an open reading frame of 2,994 bp for a new gene (Oocyte-G1), which encodes a 997-residue protein, was cloned from an ovarian cDNA library (Oocyte-G1)
Title: Molecular cloning and characterization of a new gene, Oocyte-G1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Mit256 (e-PCR), detects polymorphism
- UniSTS:126457

D11Mit257 (e-PCR), detects polymorphism
- UniSTS:126458

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axonemal microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in plus-end specific microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-like protein KIF19

Names: KIF19A-like protein; N-8 kinesin; oocyte-G1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102615.2 → NP_001096085.1 kinesin-like protein KIF19

See identical proteins and their annotated locations for NP_001096085.1

Status: VALIDATED

Source sequence(s)

AL663079

Consensus CDS

CCDS36367.1

UniProtKB/Swiss-Prot

A7DTH0, Q99PT9

UniProtKB/TrEMBL

A9XMT8

Related

ENSMUSP00000081398.6, ENSMUST00000084368.12

Conserved Domains (2) summary

smart00129
Location:14 → 353

KISc; Kinesin motor, catalytic domain. ATPase

cd01370
Location:11 → 346

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup