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    Mrpl15 mitochondrial ribosomal protein L15 [ Mus musculus (house mouse) ]

    Gene ID: 27395, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mrpl15provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L15provided by MGI
    Primary source
    MGI:MGI:1351639
    See related
    Ensembl:ENSMUSG00000033845 AllianceGenome:MGI:1351639
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L15mt; Rpml7; MRP-L7; HSPC145; MRP-L15
    Summary
    Predicted to be a structural constituent of ribosome. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in mitochondrion. Is expressed in several structures, including axial musculature; central nervous system; early conceptus; gonad; and liver. Orthologous to human MRPL15 (mitochondrial ribosomal protein L15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 6.3), CNS E11.5 (RPKM 5.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl15 in Genome Data Viewer
    Location:
    1 A1; 1 1.79 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (4843432..4855949, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (4773198..4785750, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transforming, acidic coiled-coil containing protein 3 pseudogene Neighboring gene pyruvate dehydrogenase (lipoamide) beta pseudogene Neighboring gene STARR-seq mESC enhancer starr_00039 Neighboring gene STARR-seq mESC enhancer starr_00040 Neighboring gene lysophospholipase 1 Neighboring gene predicted gene, 57794

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences. O'Brien TW, et al. J Biol Chem, 1999 Dec 17. PMID 10593885
    2. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    4. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
    5. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrial genome maintenance TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within translation ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL15m
    Names
    39S ribosomal protein L15, mitochondrial
    ribosomal protein, mitochondrial, L7
    NP_001171129.1
    NP_001407614.1
    NP_079576.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177658.2 → NP_001171129.1  large ribosomal subunit protein uL15m isoform 1 precursor

      See identical proteins and their annotated locations for NP_001171129.1

      Status: VALIDATED

      Source sequence(s)
      AC102311, AC117576
      Consensus CDS
      CCDS48211.1
      UniProtKB/Swiss-Prot
      Q3UBN5, Q9CPP5, Q9CPR5, Q9CRH4
      Related
      ENSMUSP00000115512.2, ENSMUST00000156816.7
      Conserved Domains (1) summary
      pfam00828
      Location:52 → 175
      Ribosomal_L27A; Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A

    2. NM_001420685.1 → NP_001407614.1  large ribosomal subunit protein uL15m isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102311
      UniProtKB/TrEMBL
      A0A0A6YVP4

    3. NM_025300.5 → NP_079576.1  large ribosomal subunit protein uL15m isoform 2 precursor

      See identical proteins and their annotated locations for NP_079576.1

      Status: VALIDATED

      Source sequence(s)
      AC102311, AC117576
      Consensus CDS
      CCDS35504.1
      UniProtKB/Swiss-Prot
      Q9CPR5
      Related
      ENSMUSP00000114649.2, ENSMUST00000130201.8
      Conserved Domains (1) summary
      pfam00828
      Location:52 → 175
      Ribosomal_L18e; Ribosomal protein L18e/L15

    RNA

    1. NR_033530.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102311, AC117576

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      4843432..4855949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPR5.1 GenPept UniProtKB/Swiss-Prot:Q9CPR5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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