IL17B interleukin 17B [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL17Bprovided by HGNC
Official Full Name: interleukin 17Bprovided by HGNC
Primary source: HGNC:HGNC:5982
See related: Ensembl:ENSG00000127743 MIM:604627; AllianceGenome:HGNC:5982
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NIRF; IL-20; IL-17B; ZCYTO7
Summary: The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 5q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (149374267..149404202, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (149909114..149939047, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (148753830..148783765, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda.
Title: Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda.
Potential role of INTERLEUKIN-17 in the pathogenesis of oral lichen planus: a systematic review with META-analysis.
Title: Potential role of INTERLEUKIN-17 in the pathogenesis of oral lichen planus: a systematic review with META-analysis.
Our data reveal that analogous to other IL-17 family members, IL-17B has an inflammatory role in the human system.
Title: Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes.
Gene expression microarray analysis followed by Kaplan-Meier survival curve showed that high expression level of IL-17B was associated with poor survival of patients with lung neoplasm.
Title: A positive feedback loop of IL-17B-IL-17RB activates ERK/β-catenin to promote lung cancer metastasis.
The results indicate that the IL-17B/IL-17RB signaling can promote the growth and migration of tumor cells.
Title: Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer.
Our data revealed a new mechanism that IL-17B enhanced the progression of gastric cancer by activating mesenchymal stem cells.
Title: IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells.
Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family
Title: Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing.
This comprehensive review details the recognition of activity, signaling, and the roles of IL17B-IL17RB in breast cancer have caused to determination of new therapeutic mechanisms--{REVIEW}
Title: The role of IL17B-IL17RB signaling pathway in breast cancer.
Studies indicate that interleukin 17 (IL-17B)/interleukin 17 receptor B (IL-17RB) signaling is essential for pancreatic cancer malignancy.
Title: Targeting interleukin-17 receptors.
IL-17B-IL-17RB signaling promotes pancreatic cancer malignancy.
Title: Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489844

NoName (e-PCR)
- UniSTS:482432

NoName (e-PCR)
- UniSTS:481501

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-17B

Names: cytokine-like protein ZCYTO7; interleukin 20; interleukin-17 beta; neuronal interleukin-17 related factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001317987.2 → NP_001304916.1 interleukin-17B isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AC131025, AF212311, BM826445

UniProtKB/Swiss-Prot

Q9UHF5

Related

ENST00000505432.1

Conserved Domains (1) summary

pfam06083
Location:44 → 127

IL17; Interleukin-17
NM_014443.3 → NP_055258.1 interleukin-17B isoform 1 precursor

See identical proteins and their annotated locations for NP_055258.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC131025

Consensus CDS

CCDS4297.1

UniProtKB/Swiss-Prot

Q14CE5, Q9UHF5

UniProtKB/TrEMBL

Q6IAG3

Related

ENSP00000261796.3, ENST00000261796.4

Conserved Domains (1) summary

pfam06083
Location:96 → 179

IL17; Interleukin-17

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

149374267..149404202 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017009348.2 → XP_016864837.1 interleukin-17B isoform X2

Conserved Domains (1) summary

pfam06083
Location:44 → 127

IL17; Interleukin-17
XM_017009347.2 → XP_016864836.1 interleukin-17B isoform X2

Conserved Domains (1) summary

pfam06083
Location:44 → 127

IL17; Interleukin-17
XM_047417104.1 → XP_047273060.1 interleukin-17B isoform X2
XM_017009346.2 → XP_016864835.1 interleukin-17B isoform X1