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Fgf10 fibroblast growth factor 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25443, updated on 13-Apr-2024

Summary

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Official Symbol: Fgf10provided by RGD
Official Full Name: fibroblast growth factor 10provided by RGD
Primary source: RGD:2606
See related: Ensembl:ENSRNOG00000012278 AllianceGenome:RGD:2606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fgf5a; FGF-10
Summary: Predicted to enable heparin binding activity; receptor ligand activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including angiogenesis; response to estradiol; and response to lipopolysaccharide. Acts upstream of or within organ induction. Predicted to be located in cell surface; nucleus; and plasma membrane. Predicted to be active in cytoplasm and extracellular space. Predicted to colocalize with collagen-containing extracellular matrix. Biomarker of hypospadias. Human ortholog(s) of this gene implicated in LADD syndrome and aplasia of lacrimal and salivary glands. Orthologous to human FGF10 (fibroblast growth factor 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 38.2), Uterus (RPKM 31.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

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Location:: 2q14

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (52533939..52610980)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (50801171..50878218)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (51673480..51747533)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGF 10 Inhibited Spinal Microglial Activation in Neuropathic Pain via PPAR-gamma/NF-kappaB Signaling.
Title: FGF 10 Inhibited Spinal Microglial Activation in Neuropathic Pain via PPAR-γ/NF-κB Signaling.
Testosterone exposure in prenatal life disrupts epithelial nuclear morphology, smooth muscle layer pattern, and FGF10 and Shh expression in prostate.
Title: Testosterone exposure in prenatal life disrupts epithelial nuclear morphology, smooth muscle layer pattern, and FGF10 and Shh expression in prostate.
lncRNA TUG1/miR-145-5p/FGF10 promotes the proliferation and migration of Vascular smooth muscle cell in hypertensive state by activating the Wnt/beta-catenin pathway.
Title: The lncRNA TUG1/miR-145-5p/FGF10 regulates proliferation and migration in VSMCs of hypertension.
Direct delivery of fibroblast growth factor-10 (FGF-10) in the lungs of rats led to an increase of lung-resident mesenchymal stem cells (LR-MSCs) in the treated lungs, suggesting that the protective effect of FGF-10 might be mediated, in part, by the mobilization of LR-MSCs in lungs.
Title: Fibroblast Growth Factor-10 (FGF-10) Mobilizes Lung-resident Mesenchymal Stem Cells and Protects Against Acute Lung Injury.
Suggest the potential involvement of altered Fgf10/Fgfr2/AR signaling in pathogenesis of anorectal malformations induced by di-n-butyl phthalate.
Title: Reduced Fgf10/Fgfr2 and androgen receptor (AR) in anorectal malformations male rats induced by di-n-butyl phthalate (DBP): A study on the local and systemic toxicology of DBP.
FGF10 is involved in fetal lung fluid secretion and lung branching.
Title: Abnormal control of lung branching in experimental esophageal atresia.
FGF-10 effects on lung branching morphogenesis are heparin-dependent.FGF-10 may also function in regulating branching morphogenesis or inducing cystic lung growth by inhibiting Wnt2/beta-catenin signaling.
Title: Exogenous fibroblast growth factor-10 induces cystic lung development with altered target gene expression in the presence of heparin in cultures of embryonic rat lung.
Gremlin-mediated BMP inhibition results in activation of epithelial cells and transient fibrosis, but also induction of epithelium-protective FGF10
Title: Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs.
the role of KGF1 appeared to be exclusively concerned with increased proliferation and migration at the perforation site
Title: Keratinocyte growth factor 1, fibroblast growth factor 2 and 10 in the healing tympanic membrane following perforation in rats.
FGF10 regulates Meckel's cartilage formation during early mandibular morphogenesis by controlling the cell differentiation in the lateral area of the mandibular process in rats.
Title: Fibroblast growth factor 10 regulates Meckel's cartilage formation during early mandibular morphogenesis in rats.

Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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Markers

Fgf10 (e-PCR), detects polymorphism
- UniSTS:507913

Fgf10 (e-PCR), detects polymorphism
- UniSTS:506891

Fgf10 (e-PCR), detects polymorphism
- UniSTS:516626

Fgf10 (e-PCR), detects polymorphism
- UniSTS:536432

G16001 (e-PCR)
- UniSTS:11918

PMC26870P2 (e-PCR)
- UniSTS:272357

Fgf10 (e-PCR), detects polymorphism
- UniSTS:143088

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables fibroblast growth factor receptor binding	TAS Traceable Author Statement more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables type 2 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 2 fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Harderian gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within animal organ formation	ISO Inferred from Sequence Orthology more info
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branch elongation involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bronchiole morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bud elongation involved in lung branching	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bud outgrowth involved in lung branching	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within digestive tract development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digestive tract development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermis development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermis morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
acts_upstream_of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast growth factor receptor apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway involved in mammary gland specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within induction of positive chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lacrimal gland development	ISO Inferred from Sequence Orthology more info
involved_in lacrimal gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb bud formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung epithelium development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung proximal/distal axis specification	ISO Inferred from Sequence Orthology more info
involved_in lung saccule development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland bud formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchymal cell differentiation involved in lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchymal-epithelial cell signaling involved in lung development	ISO Inferred from Sequence Orthology more info
involved_in mesonephros development	ISO Inferred from Sequence Orthology more info
involved_in metanephros development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organ growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organ induction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within organ induction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within otic vesicle formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pancreas development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pituitary gland development	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of hair follicle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lymphocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of urothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of urothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of urothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of white fat cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostatic bud formation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in radial glial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of saliva secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory system development	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in salivary gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in secretion by lung epithelial cell involved in lung growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within semicircular canal fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within semicircular canal morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spleen development	ISO Inferred from Sequence Orthology more info
acts_upstream_of stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within submandibular salivary gland formation	ISO Inferred from Sequence Orthology more info
involved_in tear secretion	ISO Inferred from Sequence Orthology more info
involved_in thymus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thyroid gland development	ISO Inferred from Sequence Orthology more info
involved_in tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within type II pneumocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in urothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within white fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of white fat cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in wound healing	IBA Inferred from Biological aspect of Ancestor more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibroblast growth factor 10

Names: fibroblast growth factor 5a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.