Tnnt2 troponin T2, cardiac type [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnnt2provided by RGD
Official Full Name: troponin T2, cardiac typeprovided by RGD
Primary source: RGD:3882
See related: Ensembl:ENSRNOG00000033734 AllianceGenome:RGD:3882
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ctt; CTTG; Tnnt3; RATCTTG
Summary: Enables protein-macromolecule adaptor activity and troponin I binding activity. Involved in actin crosslink formation; cardiac muscle contraction; and regulation of muscle filament sliding speed. Located in myofibril. Part of troponin complex. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNT2 (troponin T2, cardiac type). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 21962.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (49819123..49837125)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (47267325..47285390)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (52662974..52680992)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crossbridge Recruitment Capacity of Wild-Type and Hypertrophic Cardiomyopathy-Related Mutant Troponin-T Evaluated by X-ray Diffraction and Mechanical Study of Cardiac Skinned Fibers.
Title: Crossbridge Recruitment Capacity of Wild-Type and Hypertrophic Cardiomyopathy-Related Mutant Troponin-T Evaluated by X-ray Diffraction and Mechanical Study of Cardiac Skinned Fibers.
The Liver and Kidneys mediate clearance of cardiac troponin in the rat.
Title: The Liver and Kidneys mediate clearance of cardiac troponin in the rat.
Replacement of the functionally corresponding N-terminal end portion of rat fast skeletal cardiac muscle (RfsTnT) into cardiac muscle troponin T (RcTnT), the observed functional differences associate with a sequence variation.
Title: The tropomyosin binding region of cardiac troponin T modulates crossbridge recruitment dynamics in rat cardiac muscle fibers.
L48Q cTnC reduced crossbridge dependence of thin filament activation in cardiac muscle and changes in Ca(2+) sensitivity of force in response to changes in sarcomere length are at least partially dependent on properties of thin filament troponin.
Title: Enhanced Ca2+ binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges.
cTnC, cTnI, cTnT and cTm are not only present in myofilaments of ventricular cardiomyocytes in culture but are also within their nuclei; significantly, these four proteins appear between days 3 and 5 in both myofilaments and nuclei
Title: Nuclear cardiac troponin and tropomyosin are expressed early in cardiac differentiation of rat mesenchymal stem cells.
Early single cTnT measurement correlates with infarct size in rats, and a cutoff value of 5.1 mug/l provides good sensitivity and specificity to predict congestive heart failure with secondary pulmonary hypertension.
Title: Single measurement of troponin T for early prediction of infarct size, congestive heart failure, and pulmonary hypertension in an animal model of myocardial infarction.
The time course of cTnT elevation was temporally associated with evidence of increased lipid peroxidation in the rat heart.
Title: Temporal association of elevations in serum cardiac troponin T and myocardial oxidative stress after prolonged exercise in rats.
a novel role for cTnT as a dual-specificity sarcomeric A-kinase anchoring protein
Title: Cardiac troponin T, a sarcomeric AKAP, tethers protein kinase A at the myofilaments.
Studies show that the rat Tnnt2-rtTA;TetO-Cre mice transgenic line a valuable genetic tool for analysis of spatiotemporal gene function and cardiomyocyte lineage tracing during developmental and postnatal period.
Title: Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse.
Study demonstrate profound energetic alterations in DEL-TNT hearts, supporting the notion that inefficient cellular ATP utilization contributes to the pathogenesis of HCM.
Title: Decreased contractility due to energy deprivation in a transgenic rat model of hypertrophic cardiomyopathy.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143263 (e-PCR)
- UniSTS:232510

RH131106 (e-PCR)
- UniSTS:214389

D13Wox9 (e-PCR)
- UniSTS:118133

D13Mgh15 (e-PCR)
- UniSTS:240324

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
contributes_to microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tropomyosin binding	IEA Inferred from Electronic Annotation more info
enables tropomyosin binding	ISO Inferred from Sequence Orthology more info
enables tropomyosin binding	ISS Inferred from Sequence or Structural Similarity more info
enables troponin C binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin C binding	IEA Inferred from Electronic Annotation more info
enables troponin C binding	ISO Inferred from Sequence Orthology more info
enables troponin C binding	ISS Inferred from Sequence or Structural Similarity more info
enables troponin I binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin I binding	IEA Inferred from Electronic Annotation more info
enables troponin I binding	IPI Inferred from Physical Interaction more info	PubMed
enables troponin I binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin crosslink formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within atrial cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in muscle filament sliding	IEA Inferred from Electronic Annotation more info
involved_in muscle filament sliding	ISO Inferred from Sequence Orthology more info
involved_in muscle filament sliding	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of heart contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of muscle filament sliding speed	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sarcomere organization	ISO Inferred from Sequence Orthology more info
involved_in tissue remodeling	IEP Inferred from Expression Pattern more info	PubMed
involved_in ventricular cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of cardiac Troponin complex	IEA Inferred from Electronic Annotation more info
part_of cardiac Troponin complex	ISO Inferred from Sequence Orthology more info
located_in cardiac myofibril	IEA Inferred from Electronic Annotation more info
located_in cardiac myofibril	ISO Inferred from Sequence Orthology more info
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	ISO Inferred from Sequence Orthology more info
located_in sarcomere	ISO Inferred from Sequence Orthology more info
located_in sarcoplasm	ISO Inferred from Sequence Orthology more info
located_in striated muscle thin filament	ISO Inferred from Sequence Orthology more info
located_in striated muscle thin filament	ISS Inferred from Sequence or Structural Similarity more info
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	IDA Inferred from Direct Assay more info	PubMed
part_of troponin complex	IEA Inferred from Electronic Annotation more info
part_of troponin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: troponin T, cardiac muscle

Names: Troponin T cardiac; cTnT; cardiac muscle troponin T; cardiac troponin T2; tnTc; troponin T type 2 (cardiac)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415762.1 → NP_001402691.1 troponin T, cardiac muscle isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

B1WBR4
NM_001415763.1 → NP_001402692.1 troponin T, cardiac muscle isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A9YUA5, F1LMI8
NM_012676.2 → NP_036808.1 troponin T, cardiac muscle isoform 1

See identical proteins and their annotated locations for NP_036808.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P50753

UniProtKB/TrEMBL

F1LQ95

Conserved Domains (1) summary

pfam00992
Location:105 → 242

Troponin; Troponin