Ada adenosine deaminase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24165, updated on 11-Apr-2024

Summary

Official Symbol: Adaprovided by RGD
Official Full Name: adenosine deaminaseprovided by RGD
Primary source: RGD:2031
See related: Ensembl:ENSRNOG00000010265 AllianceGenome:RGD:2031
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables adenosine deaminase activity and purine nucleoside binding activity. Involved in several processes, including adenosine metabolic process; negative regulation of circadian sleep/wake cycle, non-REM sleep; and response to vitamin E. Located in dendrite cytoplasm; extracellular space; and neuronal cell body. Used to study hypertension; peritonitis; and pulmonary edema. Biomarker of hyperglycemia; leptospirosis; lung disease; and trypanosomiasis. Human ortholog(s) of this gene implicated in adenosine deaminase deficiency; asthma; and severe combined immunodeficiency. Orthologous to human ADA (adenosine deaminase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 737.7), Thymus (RPKM 689.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (172818174..172842283, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (152398745..152422854, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (160115840..160139947, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Quercetin decreases NTPDase, 5'-nucleotidase and adenosine deaminase activities in blood platelets of hypothyroid rats, and improves the oxidative profile to reduce platelet aggregation.
Title: Quercetin changes purinergic enzyme activities and oxidative profile in platelets of rats with hypothyroidism.
Quercetin improves memory and anxiogenic-like behavior in diabetic rats by preventing the increase in adenosine deaminase activity seen in streptozocin induced diabetes.
Title: Neuroprotective effects of quercetin on memory and anxiogenic-like behavior in diabetic rats: Role of ectonucleotidases and acetylcholinesterase activities.
The aim of this study was to identify the isoforms of adenosine deaminase (ADA) responsible for the enzymatic activity in the cerebral cortex eight days after hypoxia-ischemia.
Title: Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult.
E-NTPDase and E-ADA activities in rats experimental infected by Cryptococcus neoformans are involved in the pathogenesis of cryptococcosis.
Title: E-NTPDase and E-ADA activities in rats experimental infected by Cryptococcus neoformans.
These findings suggest that A2B receptors are involved in the regulation of colonic motility and suggest a critical role played by adenosine deaminase in modulating A2B receptor engagement by endogenous adenosine during inflammation.
Title: Role of the A(2B) receptor-adenosine deaminase complex in colonic dysmotility associated with bowel inflammation in rats.
Adenosine deaminase activity was altered in serum, lymphocytes and erythrocytes of rats, concomitantly with haematological parameters, in experimental infection by Trypanosoma evansi.
Title: Activity of the enzyme adenosine deaminase in serum, erythrocytes and lymphocytes of rats infected with Trypanosoma evansi.
AMP deaminase & ADA activities of liver & brain were investigated in acute ammonia intoxication & subacute toxic hepatitis; results suggest 2 parallel pathways of AMP breakdown, including AMP deaminase & ADA are up-regulated under pathological conditions
Title: AMP deaminase and adenosine deaminase activities in liver and brain regions in acute ammonia intoxication and subacute toxic hepatitis.
Results describe the chronological sequence of adenosine deaminase activity, oxidative damage changes and astrocyte response using a rat model of neonatal hypoxia ischemia.
Title: Adenosine deaminase activity, lipid peroxidation and astrocyte responses in the cerebral cortex of rats after neonatal hypoxia ischemia.
elevation of renal tissue and interstitial adenosine contributes to the renal vasoconstriction observed in the ANG II-induced hypertension; it is mediated in part by a decrease in the activity and expression of ADA
Title: Renal interstitial adenosine is increased in angiotensin II-induced hypertensive rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2'-deoxyadenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables 2'-deoxyadenosine deaminase activity	ISO Inferred from Sequence Orthology more info
enables adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosine deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables adenosine deaminase activity	ISO Inferred from Sequence Orthology more info
enables adenosine deaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deaminase activity	ISO Inferred from Sequence Orthology more info
enables purine nucleoside binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in AMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in AMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in AMP salvage	IEA Inferred from Electronic Annotation more info
involved_in AMP salvage	ISO Inferred from Sequence Orthology more info
involved_in B cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in GMP salvage	IEA Inferred from Electronic Annotation more info
involved_in GMP salvage	ISO Inferred from Sequence Orthology more info
involved_in Peyer's patch development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Peyer's patch development	ISO Inferred from Sequence Orthology more info
involved_in T cell activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
acts_upstream_of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenosine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in adenosine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adenosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in adenosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in adenosine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenosine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in adenosine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in adenosine metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in allantoin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in allantoin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in amide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in amide catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in dAMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in dAMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dATP catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dATP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in deoxyadenosine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within deoxyadenosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in deoxyadenosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in embryonic digestive tract development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in germinal center B cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within germinal center B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in germinal center formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of germinal center formation	ISO Inferred from Sequence Orthology more info
involved_in histamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypoxanthine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hypoxanthine salvage	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in inosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inosine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inosine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in inosine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in inosine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukocyte migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in mature B cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of mature B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in mucus secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenosine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of circadian sleep/wake cycle, non-REM sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mature B cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mature B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mucus secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of penile erection	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of penile erection	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of thymocyte apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of thymocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in penile erection	IEA Inferred from Electronic Annotation more info
acts_upstream_of penile erection	ISO Inferred from Sequence Orthology more info
involved_in placenta development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within placenta development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of germinal center formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of germinal center formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in purine nucleotide salvage	ISO Inferred from Sequence Orthology more info
involved_in purine ribonucleoside monophosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell-cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian sleep/wake cycle, sleep	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to L-arginine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to inorganic substance	IEA Inferred from Electronic Annotation more info
involved_in response to inorganic substance	ISO Inferred from Sequence Orthology more info
involved_in response to purine-containing compound	IEA Inferred from Electronic Annotation more info
involved_in response to purine-containing compound	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin E	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in smooth muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in thymocyte apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of thymocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in trophectodermal cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trophectodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in xanthine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within xanthine biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle lumen	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenosine deaminase

Names: adenosine aminohydrolase

NP_569083.1

EC 3.5.4.4

XP_038960158.1

EC 3.5.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130399.2 → NP_569083.1 adenosine deaminase

See identical proteins and their annotated locations for NP_569083.1

Status: PROVISIONAL

Source sequence(s)

BC088116

UniProtKB/Swiss-Prot

Q920P6

UniProtKB/TrEMBL

A0A8I6AB50, A6JX48

Related

ENSRNOP00000014151.3, ENSRNOT00000014151.7

Conserved Domains (1) summary

cl00281
Location:9 → 347

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

172818174..172842283 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104230.2 → XP_038960158.1 adenosine deaminase isoform X1

UniProtKB/TrEMBL

A0A8I6ANW5, A0A8I6GI51

Related

ENSRNOP00000090362.1

Conserved Domains (1) summary

cl00281
Location:24 → 341

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...