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    Atxn7l3 ataxin 7-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 217218, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Atxn7l3provided by MGI
    Official Full Name
    ataxin 7-like 3provided by MGI
    Primary source
    MGI:MGI:3036270
    See related
    Ensembl:ENSMUSG00000059995 AllianceGenome:MGI:3036270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E030022H21Rik
    Summary
    Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in protein modification by small protein conjugation or removal and regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Predicted to be part of DUBm complex and SAGA complex. Orthologous to human ATXN7L3 (ataxin 7 like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 32.3), whole brain E14.5 (RPKM 28.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 66.29 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102180126..102187615, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102289300..102297045, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E911 Neighboring gene homologous recombination factor with OB-fold Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102128926-102129035 Neighboring gene ankyrin repeat and SOCS box-containing 16 Neighboring gene STARR-positive B cell enhancer ABC_E1432 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102156604-102156807 Neighboring gene transmembrane and ubiquitin-like domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E469 Neighboring gene predicted gene, 33851 Neighboring gene STARR-positive B cell enhancer ABC_E5281 Neighboring gene upstream binding transcription factor, RNA polymerase I Neighboring gene STARR-seq mESC enhancer starr_30800 Neighboring gene solute carrier family 4 (anion exchanger), member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription. Wang F, et al. Cell Death Differ, 2021 Aug. PMID 33731875, Free PMC Article
    2. The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription. Bonnet J, et al. Genes Dev, 2014 Sep 15. PMID 25228644, Free PMC Article
    3. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. Brand M, et al. EMBO J, 2001 Jun 15. PMID 11406595, Free PMC Article
    4. Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Khang R, et al. Sci Rep, 2021 Nov 23. PMID 34815492, Free PMC Article
    5. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. Brand M, et al. J Biol Chem, 1999 Jun 25. PMID 10373431

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC161359

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DUBm complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DUBm complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ataxin-7-like protein 3
    Names
    SAGA-associated factor 11 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098836.2 → NP_001092306.1  ataxin-7-like protein 3 isoform a

      See identical proteins and their annotated locations for NP_001092306.1

      Status: VALIDATED

      Source sequence(s)
      AL954730
      Consensus CDS
      CCDS48942.1
      UniProtKB/TrEMBL
      Z4YN62
      Related
      ENSMUSP00000102750.3, ENSMUST00000107132.3
      Conserved Domains (2) summary
      pfam08209
      Location:80 → 112
      Sgf11; Sgf11 (transcriptional regulation protein)
      pfam08313
      Location:215 → 244
      SCA7; zinc-binding domain

    2. NM_001098837.2 → NP_001092307.1  ataxin-7-like protein 3 isoform b

      See identical proteins and their annotated locations for NP_001092307.1

      Status: VALIDATED

      Source sequence(s)
      AL954730
      Consensus CDS
      CCDS48941.1
      UniProtKB/Swiss-Prot
      A2AWT2, A2AWT3, A2AWT4, Q8C1T7
      UniProtKB/TrEMBL
      Z4YN62
      Related
      ENSMUSP00000072967.3, ENSMUST00000073234.9
      Conserved Domains (2) summary
      pfam08209
      Location:80 → 112
      Sgf11; Sgf11 (transcriptional regulation protein)
      pfam08313
      Location:208 → 237
      SCA7; zinc-binding domain

    3. NM_001403848.1 → NP_001390777.1  ataxin-7-like protein 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL954730

    4. NM_001403849.1 → NP_001390778.1  ataxin-7-like protein 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL954730
      UniProtKB/Swiss-Prot
      A2AWT2, A2AWT3, A2AWT4, Q8C1T7

    5. NM_001403850.1 → NP_001390779.1  ataxin-7-like protein 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL954730
      UniProtKB/Swiss-Prot
      A2AWT2, A2AWT3, A2AWT4, Q8C1T7

    6. NM_001403852.1 → NP_001390781.1  ataxin-7-like protein 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL954730

    7. NM_001403854.1 → NP_001390783.1  ataxin-7-like protein 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL954730

    8. NM_001403855.1 → NP_001390784.1  ataxin-7-like protein 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL954730

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102180126..102187615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533045.4 → XP_006533108.1  ataxin-7-like protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006533108.1

      Conserved Domains (2) summary
      pfam08209
      Location:80 → 112
      Sgf11; Sgf11 (transcriptional regulation protein)
      pfam08313
      Location:234 → 263
      SCA7; zinc-binding domain

    2. XM_036156595.1 → XP_036012488.1  ataxin-7-like protein 3 isoform X7

      Conserved Domains (1) summary
      pfam08313
      Location:108 → 137
      SCA7; zinc-binding domain

    3. XM_036156592.1 → XP_036012485.1  ataxin-7-like protein 3 isoform X2

      Conserved Domains (2) summary
      pfam08209
      Location:80 → 112
      Sgf11; Sgf11 (transcriptional regulation protein)
      pfam08313
      Location:234 → 263
      SCA7; zinc-binding domain

    4. XM_036156594.1 → XP_036012487.1  ataxin-7-like protein 3 isoform X6

      Related
      ENSMUSP00000121917.2, ENSMUST00000141516.8
      Conserved Domains (1) summary
      pfam08313
      Location:127 → 156
      SCA7; zinc-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AWT3.1 GenPept UniProtKB/Swiss-Prot:A2AWT3

    Gene LinkOut

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