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    ZNF449 zinc finger protein 449 [ Homo sapiens (human) ]

    Gene ID: 203523, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF449provided by HGNC
    Official Full Name
    zinc finger protein 449provided by HGNC
    Primary source
    HGNC:HGNC:21039
    See related
    Ensembl:ENSG00000173275 MIM:300627; AllianceGenome:HGNC:21039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZSCAN19
    Summary
    This gene encodes a nuclear protein that likely functions as a transcription factor. The protein includes an N-terminal SCAN domain, and seven C2H2-type zinc finger motifs. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in adrenal (RPKM 2.8), thyroid (RPKM 2.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    Xq26.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135344796..135363413)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (133670603..133689215)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134478721..134497338)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 75D Neighboring gene uncharacterized LOC105373342 Neighboring gene embryonic testis differentiation homolog C Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:134471438-134471938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:134471939-134472439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21019 Neighboring gene uncharacterized LOC100506790 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:134539161-134540038 Neighboring gene NANOG hESC enhancer GRCh37_chrX:134542673-134543175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21020 Neighboring gene small integral membrane protein 10 like 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the human SCAN domain zinc-finger gene ZNF449. Luo K, et al. Mol Biol Rep, 2006 Mar. PMID 16636917
    2. Identification of SCAN domain zinc-finger gene ZNF449 as a novel factor of chondrogenesis. Okada K, et al. PLoS One, 2014. PMID 25546433, Free PMC Article
    3. Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. Cheng J, et al. Science, 2005 May 20. PMID 15790807
    4. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. Virok DP, et al. J Proteome Res, 2011 Apr 1. PMID 21244100
    5. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23614

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogonial cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 449
    Names
    zinc finger and SCAN domain-containing protein 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021220.1 RefSeqGene

      Range
      5026..23643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_152695.6 → NP_689908.3  zinc finger protein 449

      See identical proteins and their annotated locations for NP_689908.3

      Status: REVIEWED

      Source sequence(s)
      AY280801, BC060768, BX537604, DA319333
      Consensus CDS
      CCDS14649.1
      UniProtKB/Swiss-Prot
      Q5JRZ7, Q5JRZ8, Q6NZX2, Q6P9G9, Q8N3Q1, Q8TED7
      Related
      ENSP00000339585.4, ENST00000339249.5
      Conserved Domains (5) summary
      COG5048
      Location:321 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:235 → 402
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:325 → 345
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:477 → 502
      zf-H2C2_2; Zinc-finger double domain
      cl02605
      Location:27 → 134
      SCAN; SCAN oligomerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      135344796..135363413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441915.1 → XP_047297871.1  zinc finger protein 449 isoform X2

    2. XM_047441914.1 → XP_047297870.1  zinc finger protein 449 isoform X1

      UniProtKB/Swiss-Prot
      Q5JRZ7, Q5JRZ8, Q6NZX2, Q6P9G9, Q8N3Q1, Q8TED7

    3. XM_017029351.2 → XP_016884840.1  zinc finger protein 449 isoform X2

      Conserved Domains (5) summary
      cd11674
      Location:178 → 231
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:206 → 359
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:208 → 230
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:306 → 331
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      133670603..133689215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326678.1 → XP_054182653.1  zinc finger protein 449 isoform X2

    2. XM_054326677.1 → XP_054182652.1  zinc finger protein 449 isoform X1

      UniProtKB/Swiss-Prot
      Q5JRZ7, Q5JRZ8, Q6NZX2, Q6P9G9, Q8N3Q1, Q8TED7

    3. XM_054326679.1 → XP_054182654.1  zinc finger protein 449 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P9G9.3 GenPept UniProtKB/Swiss-Prot:Q6P9G9

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