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    Sirpa signal-regulatory protein alpha [ Mus musculus (house mouse) ]

    Gene ID: 19261, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Sirpaprovided by MGI
    Official Full Name
    signal-regulatory protein alphaprovided by MGI
    Primary source
    MGI:MGI:108563
    See related
    Ensembl:ENSMUSG00000037902 AllianceGenome:MGI:108563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; Idd13.2
    Summary
    Enables protein phosphatase binding activity and protein phosphorylated amino acid binding activity. Involved in several processes, including negative regulation of MAPK cascade; negative regulation of cytokine production; and negative regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; phagocytosis; and positive regulation of phagocytosis. Is integral component of plasma membrane. Is expressed in several structures, including adrenal gland; cartilage; central nervous system; genitourinary system; and retina. Orthologous to several human genes including SIRPA (signal regulatory protein alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cortex adult (RPKM 59.8), frontal lobe adult (RPKM 57.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sirpa in Genome Data Viewer
    Location:
    2 F1; 2 63.19 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (129432962..129474148)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (129591042..129632228)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F830045P16 gene Neighboring gene predicted gene 14040 Neighboring gene STARR-seq mESC enhancer starr_05673 Neighboring gene predicted gene 14041 Neighboring gene STARR-seq mESC enhancer starr_05675 Neighboring gene STARR-seq mESC enhancer starr_05676 Neighboring gene STARR-seq mESC enhancer starr_05677 Neighboring gene prodynorphin Neighboring gene STARR-seq mESC enhancer starr_05678 Neighboring gene STARR-seq mESC enhancer starr_05679 Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene 2_1620.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Soluble SIRP-Alpha Promotes Murine Acute Lung Injury Through Suppressing Macrophage Phagocytosis. Shen Q, et al. Front Immunol, 2022. PMID 35634325, Free PMC Article
    2. Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells. Ren B, et al. Elife, 2022 May 5. PMID 35511221, Free PMC Article
    3. Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy. Bian Z, et al. Nat Commun, 2021 May 28. PMID 34050181, Free PMC Article
    4. Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration. Ding X, et al. Nat Commun, 2021 Apr 1. PMID 33795678, Free PMC Article
    5. Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance. Gauttier V, et al. J Clin Invest, 2020 Nov 2. PMID 33074246, Free PMC Article

    See all (207) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPalpha.
      Title: Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.
    2. SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.
      Title: SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.
    3. Blocking the CD47-SIRPalpha interaction reverses the disease phenotype in a polycythemia vera mouse model.
      Title: Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model.
    4. Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina.
      Title: Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina.
    5. SIRPalpha maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.
      Title: SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.
    6. SIRPalpha Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.
      Title: SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.
    7. Endothelial SIRPalpha signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.
      Title: Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.
    8. SIRPalpha - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.
      Title: SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.
    9. Augmentation of CD47/SIRPalpha signaling protects cones in genetic models of retinal degeneration.
      Title: Augmentation of CD47/SIRPα signaling protects cones in genetic models of retinal degeneration.
    10. Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha.
      Title: Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha.
    Submit: New GeneRIF Correction See all GeneRIFs (130)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cell-cell adhesion mediator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding involved in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphorylated amino acid binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interleukin-12 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in granulocyte migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monocyte extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of I-kappaB phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of chemokine (C-C motif) ligand 5 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytokine production involved in inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of macrophage inflammatory protein 1 alpha production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phagocytosis, engulfment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phagocytosis, recognition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type substrate 1
    Names
    CD172 antigen-like family member A
    SHP substrate 1
    brain Ig-like molecule with tyrosine-based activation motifs
    brain immunological-like with tyrosine-based motifs
    inhibitory receptor SHPS-1
    mSIRP-alpha1
    myD-1 antigen
    protein tyrosine phosphatase, non-receptor type substrate 1
    signal-regulatory protein alpha-1
    sirp-alpha-1
    NP_001171118.1
    NP_001277948.1
    NP_001277949.1
    NP_001277950.1
    NP_001277951.1
    NP_001342087.1
    NP_001342089.1
    NP_001407695.1
    NP_001407696.1
    NP_001407697.1
    NP_001407698.1
    NP_001407699.1
    NP_001407700.1
    NP_001407701.1
    NP_031573.2
    XP_017172053.1
    XP_017172057.1
    XP_017172058.1
    XP_030104595.1
    XP_030104598.1
    XP_036015585.1
    XP_036015587.1
    XP_036015588.1
    XP_036015589.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177647.3 → NP_001171118.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001171118.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (2) is shorter than isoform 3.
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS50708.1
      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      A0A0R4J1Z7
      Related
      ENSMUSP00000125004.2, ENSMUST00000160276.2
      Conserved Domains (1) summary
      cl11960
      Location:35 → 146
      Ig; Immunoglobulin domain

    2. NM_001291019.2 → NP_001277948.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001277948.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3). Both variants 4 and 5 encode isoform 3.
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS71142.1
      UniProtKB/Swiss-Prot
      A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4
      UniProtKB/TrEMBL
      Q2M4I8
      Related
      ENSMUSP00000049022.8, ENSMUST00000049262.14
      Conserved Domains (4) summary
      cd00096
      Location:35 → 38
      Ig; Ig strand A [structural motif]
      cd05772
      Location:148 → 250
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:253 → 348
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35 → 146
      Ig; Immunoglobulin domain

    3. NM_001291020.2 → NP_001277949.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001277949.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Both variants 4 and 5 encode isoform 3.
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS71142.1
      UniProtKB/Swiss-Prot
      A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4
      UniProtKB/TrEMBL
      Q2M4I8
      Related
      ENSMUSP00000124048.2, ENSMUST00000161620.8
      Conserved Domains (4) summary
      cd00096
      Location:35 → 38
      Ig; Ig strand A [structural motif]
      cd05772
      Location:148 → 250
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:253 → 348
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35 → 146
      Ig; Immunoglobulin domain

    4. NM_001291021.2 → NP_001277950.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate in-frame exons in the central coding region, compared to variant 4, resulting in an isoform (4) that is shorter than isoform 3. Variants 6 and 10 both encode the same isoform (4).
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS71143.1
      UniProtKB/TrEMBL
      E9QPT7
      Related
      ENSMUSP00000096713.4, ENSMUST00000099113.10
      Conserved Domains (1) summary
      cl11960
      Location:35 → 146
      Ig; Immunoglobulin domain

    5. NM_001291022.2 → NP_001277951.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 5' coding region and two in-frame exons in the central coding region, and also uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (5) is shorter than isoform 3.
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS79845.1
      UniProtKB/TrEMBL
      E0CX65
      Related
      ENSMUSP00000124888.2, ENSMUST00000163034.8

    6. NM_001355158.2 → NP_001342087.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) encodes isoform 1. Variants 1, 8, 11, and 12 all encode the same isoform (1).
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS16729.1
      UniProtKB/TrEMBL
      Q2M4I8, Q6P6I8
      Related
      ENSMUSP00000137611.2, ENSMUST00000179001.8
      Conserved Domains (3) summary
      cd05772
      Location:148 → 251
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:253 → 356
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35 → 146
      Ig; Immunoglobulin domain

    7. NM_001355160.1 → NP_001342089.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL808126
      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (3) summary
      cd05772
      Location:136 → 239
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:241 → 344
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:23 → 134
      Ig; Immunoglobulin domain

    8. NM_001420766.1 → NP_001407695.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL808126
      UniProtKB/Swiss-Prot
      A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4

    9. NM_001420767.1 → NP_001407696.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL808126
      UniProtKB/TrEMBL
      Q6P6I8

    10. NM_001420768.1 → NP_001407697.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL808126
      UniProtKB/TrEMBL
      Q6P6I8

    11. NM_001420769.1 → NP_001407698.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AL808126

    12. NM_001420770.1 → NP_001407699.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL808126

    13. NM_001420771.1 → NP_001407700.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL808126

    14. NM_001420772.1 → NP_001407701.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL808126

    15. NM_007547.5 → NP_031573.2  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_031573.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 4, resulting in an isoform (1) that is shorter than isoform 3. Variants 1, 8, 11, and 12 all encode the same isoform (1).
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS16729.1
      UniProtKB/TrEMBL
      Q2M4I8, Q6P6I8
      Related
      ENSMUSP00000099491.4, ENSMUST00000103202.10
      Conserved Domains (3) summary
      cd05772
      Location:148 → 251
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:253 → 356
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35 → 146
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      129432962..129474148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316564.2 → XP_017172053.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:28 → 31
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141 → 243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246 → 341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28 → 139
      Ig; Immunoglobulin domain

    2. XM_036159695.1 → XP_036015588.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:28 → 31
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141 → 243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246 → 341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28 → 139
      Ig; Immunoglobulin domain

    3. XM_017316568.2 → XP_017172057.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X5

      UniProtKB/TrEMBL
      E9QPT7
      Conserved Domains (1) summary
      cl11960
      Location:35 → 146
      Ig; Immunoglobulin domain

    4. XM_017316569.2 → XP_017172058.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X6

      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      A0A0R4J1Z7
      Conserved Domains (1) summary
      cl11960
      Location:35 → 146
      Ig; Immunoglobulin domain

    5. XM_036159694.1 → XP_036015587.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:28 → 31
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141 → 243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246 → 341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28 → 139
      Ig; Immunoglobulin domain

    6. XM_036159692.1 → XP_036015585.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X3

      UniProtKB/Swiss-Prot
      A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4
      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:35 → 38
      Ig; Ig strand A [structural motif]
      cd05772
      Location:148 → 250
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:253 → 348
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35 → 146
      Ig; Immunoglobulin domain

    7. XM_030248735.2 → XP_030104595.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:28 → 31
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141 → 243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246 → 341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28 → 139
      Ig; Immunoglobulin domain

    8. XM_030248738.2 → XP_030104598.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:28 → 31
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141 → 243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246 → 341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28 → 139
      Ig; Immunoglobulin domain

    9. XM_036159696.1 → XP_036015589.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:28 → 31
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141 → 243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246 → 341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28 → 139
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001177646.1: Suppressed sequence

      Description
      NM_001177646.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97797.2 GenPept UniProtKB/Swiss-Prot:P97797

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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