Dmp1 dentin matrix protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmp1provided by MGI
Official Full Name: dentin matrix protein 1provided by MGI
Primary source: MGI:MGI:94910
See related: Ensembl:ENSMUSG00000029307 AllianceGenome:MGI:94910
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PP; AG1; Dmp; DMP-1
Summary: Enables extracellular matrix binding activity. Acts upstream of or within extracellular matrix organization; positive regulation of cell-substrate adhesion; and regulation of enamel mineralization. Located in extracellular matrix and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and stylopod. Used to study autosomal recessive hypophosphatemic rickets. Orthologous to human DMP1 (dentin matrix acidic phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 1.9), frontal lobe adult (RPKM 1.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E5; 5 50.61 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (104345441..104361968)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (104197575..104214102)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice.
Title: FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice.
The role of proteoglycan form of DMP1 in cranial repair.
Title: The role of proteoglycan form of DMP1 in cranial repair.
Improved cognitive impairments by silencing DMP1 via enhancing the proliferation of neural progenitor cell in Alzheimer-like mice.
Title: Improved cognitive impairments by silencing DMP1 via enhancing the proliferation of neural progenitor cell in Alzheimer-like mice.
Osteocytes but not osteoblasts directly build mineralized bone structures.
Title: Osteocytes but not osteoblasts directly build mineralized bone structures.
Pten deletion in Dmp1-expressing cells does not rescue the osteopenic effects of Wnt/beta-catenin suppression.
Title: Pten deletion in Dmp1-expressing cells does not rescue the osteopenic effects of Wnt/β-catenin suppression.
Glycosylation of DMP1 promotes bone reconstruction in long bone defects.
Title: Glycosylation of DMP1 promotes bone reconstruction in long bone defects.
Glycosylation of DMP1 maintains cranial sutures in mice.
Title: Glycosylation of DMP1 maintains cranial sutures in mice.
Upon inspection, fewer cartilaginous calluses and down-regulated expression levels of chondrogenesis genes were observed in the fracture sites of S89G-DMP1 mice. The results suggest that DMP1-PG is an indispensable proteoglycan in chondrogenesis during fracture healing.
Title: Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis.
results suggest that the expression of Dmp1 is up-regulated in Opn KO mice both in vivo and in vitro, and DMP1 compensates for the lack of OPN in regulating odontoblastlike cell differentiation after tooth injury.
Title: Dentin Matrix Protein 1 Compensates for Lack of Osteopontin in Regulating Odontoblastlike Cell Differentiation after Tooth Injury in Mice.
Twist1 Inactivation in Dmp1-Expressing Cells Increases Bone Mass but Does Not Affect the Anabolic Response to Sclerostin Neutralization.
Title: Twist1 Inactivation in Dmp1-Expressing Cells Increases Bone Mass but Does Not Affect the Anabolic Response to Sclerostin Neutralization.

Submit: New GeneRIF Correction See all GeneRIFs (71)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV020965 (e-PCR)
- UniSTS:179216

Dmp1 (e-PCR), detects polymorphism
- UniSTS:498372

Dmp1 (e-PCR), detects polymorphism
- UniSTS:498429

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix binding	IDA Inferred from Direct Assay more info	PubMed
enables ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	IDA Inferred from Direct Assay more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of enamel mineralization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dentin matrix acidic phosphoprotein 1

Names: serine rich acidic phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359013.1 → NP_001345942.1 dentin matrix acidic phosphoprotein 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC164587

Consensus CDS

CCDS19484.1

UniProtKB/Swiss-Prot

O55188, Q3TZB6

Conserved Domains (1) summary

pfam07263
Location:1 → 503

DMP1; Dentin matrix protein 1 (DMP1)
NM_016779.2 → NP_058059.2 dentin matrix acidic phosphoprotein 1 precursor

See identical proteins and their annotated locations for NP_058059.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AK132177

Consensus CDS

CCDS19484.1

UniProtKB/Swiss-Prot

O55188, Q3TZB6

Related

ENSMUSP00000068053.6, ENSMUST00000066708.7

Conserved Domains (1) summary

pfam07263
Location:1 → 503

DMP1; Dentin matrix protein 1 (DMP1)