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    Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 [ Mus musculus (house mouse) ]

    Gene ID: 12499, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Entpd5provided by MGI
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 5provided by MGI
    Primary source
    MGI:MGI:1321385
    See related
    Ensembl:ENSMUSG00000021236 AllianceGenome:MGI:1321385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pcph; Cd39l4; mNTPase; NTPDase5; ER-UDPase; NTPDase-5
    Summary
    Enables guanosine-diphosphatase activity and uridine-diphosphatase activity. Involved in several processes, including positive regulation of glycolytic process; protein N-linked glycosylation; and regulation of phosphatidylinositol 3-kinase signaling. Located in endoplasmic reticulum. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and nose. Orthologous to human ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 30.8), bladder adult (RPKM 19.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 D1; 12 39.18 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84420649..84455803, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84373875..84409029, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 410 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene family with sequence similarity 161, member B Neighboring gene STARR-positive B cell enhancer ABC_E1445 Neighboring gene coenzyme Q6 monooxygenase Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:85729760-85729947 Neighboring gene STARR-positive B cell enhancer ABC_E8493 Neighboring gene basal body orientation factor 1 Neighboring gene ring finger protein 113A2 Neighboring gene aldehyde dehydrogenase family 6, subfamily A1 Neighboring gene STARR-positive B cell enhancer ABC_E80

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ectonucleoside triphosphate diphosphohydrolase type 5 (Entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest. Read R, et al. Vet Pathol, 2009 May. PMID 19176496
    2. The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation. Xu L, et al. Cell Death Dis, 2023 Feb 27. PMID 36849424, Free PMC Article
    3. Sequencing, functional expression and characterization of rat NTPDase6, a nucleoside diphosphatase and novel member of the ecto-nucleoside triphosphate diphosphohydrolase family. Braun N, et al. Biochem J, 2000 Nov 1. PMID 11042118, Free PMC Article
    4. Glycoprotein reglucosylation and nucleotide sugar utilization in the secretory pathway: identification of a nucleoside diphosphatase in the endoplasmic reticulum. Trombetta ES, et al. EMBO J, 1999 Jun 15. PMID 10369669, Free PMC Article
    5. The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Fang M, et al. Cell, 2010 Nov 24. PMID 21074248

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation.
      Title: The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation.
    2. Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 regulation: cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1.
      Title: Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.
    3. During a study using the embryonic fibroblasts from the PTEN null mice ENTPD5, is found to be upregulated by AKT activation; this enzyme seems to mediate many of the observed cancer-related phenotypes associated with AKT activation.
      Title: The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.
    4. The effect of Entpd5 deletion on the development of hepatocellualr neoplasia in mice is reported.
      Title: Ectonucleoside triphosphate diphosphohydrolase type 5 (Entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables CDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables IDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect 'de novo' post-translational protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in UDP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_positive_effect UDP-glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleoside diphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_positive_effect protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 5
    Names
    CD39 antigen-like 4
    GDPase ENTPD5
    NTPDase 5
    UDPase ENTPD5
    guanosine-diphosphatase ENTPD5
    nucleoside diphosphatase
    uridine-diphosphatase ENTPD5
    NP_001021385.1
    NP_001272978.1
    NP_001272987.1
    NP_031673.2
    XP_030102393.1
    XP_036013066.1
    XP_036013067.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001026214.2 → NP_001021385.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform b precursor

      See identical proteins and their annotated locations for NP_001021385.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the predominant protein (isoform b). Variants 2, 3 and 4 encode the same isoform b.
      Source sequence(s)
      AK081435, AK160950, BY049870, CD775710
      Consensus CDS
      CCDS26045.1
      UniProtKB/Swiss-Prot
      O70214, Q544J4, Q8BR23, Q8CD29, Q9WUZ9
      Related
      ENSMUSP00000105901.3, ENSMUST00000110272.9
      Conserved Domains (1) summary
      cl17037
      Location:38 → 423
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. NM_001286049.1 → NP_001272978.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform b precursor

      See identical proteins and their annotated locations for NP_001272978.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. It encodes the predominant protein (isoform b). Variants 2, 3 and 4 encode the same isoform b.
      Source sequence(s)
      AC120402, AK002618, AK160950, CD775710
      Consensus CDS
      CCDS26045.1
      UniProtKB/Swiss-Prot
      O70214, Q544J4, Q8BR23, Q8CD29, Q9WUZ9
      Related
      ENSMUSP00000113106.2, ENSMUST00000122194.8
      Conserved Domains (1) summary
      cl17037
      Location:38 → 423
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. NM_001286058.1 → NP_001272987.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform b precursor

      See identical proteins and their annotated locations for NP_001272987.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. It encodes the predominant protein (isoform b). Variants 2, 3 and 4 encode the same isoform b.
      Source sequence(s)
      AC120402, AK079267, AK160950, CD775710
      Consensus CDS
      CCDS26045.1
      UniProtKB/Swiss-Prot
      O70214, Q544J4, Q8BR23, Q8CD29, Q9WUZ9
      Related
      ENSMUSP00000114011.2, ENSMUST00000117286.2
      Conserved Domains (1) summary
      cl17037
      Location:38 → 423
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    4. NM_007647.3 → NP_031673.2  ectonucleoside triphosphate diphosphohydrolase 5 isoform a

      See identical proteins and their annotated locations for NP_031673.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an internal exon in the 5' region, which results in an upstream AUG start codon, compared to variant 2. The resulting isoform (a) has a longer N-terminus, compared to isoform b.
      Source sequence(s)
      AK160950, AK163688, BY049870, CD775710
      Consensus CDS
      CCDS36491.1
      UniProtKB/TrEMBL
      Q3TQC7
      Related
      ENSMUSP00000071939.6, ENSMUST00000072061.12
      Conserved Domains (1) summary
      cl17037
      Location:63 → 448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84420649..84455803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157174.1 → XP_036013067.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X2

      UniProtKB/Swiss-Prot
      O70214, Q544J4, Q8BR23, Q8CD29, Q9WUZ9
      Conserved Domains (1) summary
      cl17037
      Location:38 → 423
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. XM_036157173.1 → XP_036013066.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X1

      UniProtKB/TrEMBL
      Q3TQC7
      Conserved Domains (1) summary
      cl17037
      Location:63 → 448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. XM_030246533.1 → XP_030102393.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X2

      UniProtKB/Swiss-Prot
      O70214, Q544J4, Q8BR23, Q8CD29, Q9WUZ9
      Conserved Domains (1) summary
      cl17037
      Location:38 → 423
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUZ9.1 GenPept UniProtKB/Swiss-Prot:Q9WUZ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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