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    Sec22a SEC22 homolog A, vesicle trafficking protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117513, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sec22aprovided by RGD
    Official Full Name
    SEC22 homolog A, vesicle trafficking proteinprovided by RGD
    Primary source
    RGD:621659
    See related
    Ensembl:ENSRNOG00000043069 AllianceGenome:RGD:621659
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sec22l2
    Summary
    Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Is integral component of membrane. Orthologous to human SEC22A (SEC22 homolog A, vesicle trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 123.3), Liver (RPKM 79.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    11q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (78907552..78967575)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (65402583..65462329)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (68633080..68686553)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase family A, member 5 Neighboring gene uncharacterized LOC120095661 Neighboring gene uncharacterized LOC120095660 Neighboring gene uncharacterized LOC102551038 Neighboring gene adenylate cyclase 5 Neighboring gene uncharacterized LOC134481009

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus. Hay JC, et al. J Biol Chem, 1996 Mar 8. PMID 8621431
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vesicle-trafficking protein SEC22a
    Names
    SEC22 vesicle trafficking protein homolog A
    SEC22 vesicle-trafficking protein-like 2
    rSec22a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057147.2 → NP_476488.2  vesicle-trafficking protein SEC22a

      See identical proteins and their annotated locations for NP_476488.2

      Status: PROVISIONAL

      Source sequence(s)
      BC081746
      UniProtKB/Swiss-Prot
      Q62891, Q642F4
      UniProtKB/TrEMBL
      A0A8I6G2P2, A6IRG9
      Conserved Domains (1) summary
      cd14824
      Location:5 → 126
      Longin; longin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      78907552..78967575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768693.4 → XP_008766915.3  vesicle-trafficking protein SEC22a isoform X1

    2. XM_039087918.2 → XP_038943846.1  vesicle-trafficking protein SEC22a isoform X2

      Conserved Domains (1) summary
      cd14824
      Location:1 → 56
      Longin; longin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q642F4.1 GenPept UniProtKB/Swiss-Prot:Q642F4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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