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    Meig1 meiosis expressed gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 104362, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Meig1provided by MGI
    Official Full Name
    meiosis expressed gene 1provided by MGI
    Primary source
    MGI:MGI:1202878
    See related
    Ensembl:ENSMUSG00000026650 AllianceGenome:MGI:1202878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Meg1; MLZ-278
    Summary
    Acts upstream of or within cellular protein localization; manchette assembly; and sperm axoneme assembly. Located in cytosol; manchette; and nucleus. Is expressed in ovary; retina; and testis. Orthologous to human MEIG1 (meiosis/spermiogenesis associated 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 245.0) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 A1; 2 1.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3410080..3423685, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3409043..3422648, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene oleoyl-ACP hydrolase Neighboring gene STARR-seq mESC enhancer starr_03512 Neighboring gene predicted gene, 39750 Neighboring gene STARR-positive B cell enhancer ABC_E5880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:3341062-3341360 Neighboring gene DNA cross-link repair 1C Neighboring gene STARR-seq mESC enhancer starr_03514 Neighboring gene suppressor of variegation 3-9 2 Neighboring gene STARR-seq mESC enhancer starr_03515 Neighboring gene predicted gene, 54099 Neighboring gene heat shock protein 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A single amino acid mutation in the mouse MEIG1 protein disrupts a cargo transport system necessary for sperm formation. Li W, et al. J Biol Chem, 2021 Nov. PMID 34673028, Free PMC Article
    2. Mouse meiosis expressed gene 1 is not phosphorylated in vivo. Li W, et al. Mol Reprod Dev, 2018 Apr. PMID 29393537, Free PMC Article
    3. Meig1 deficiency causes a severe defect in mouse spermatogenesis. Salzberg Y, et al. Dev Biol, 2010 Feb 15. PMID 20004656
    4. Two alternatively spliced Meig1 messenger RNA species are differentially expressed in the somatic and in the germ-cell compartments of the testis. Ever L, et al. Cell Growth Differ, 1999 Jan. PMID 9950214
    5. Developmentally regulated expression during gametogenesis of the murine gene meg1 suggests a role in meiosis. Don J, et al. Mol Reprod Dev, 1994 May. PMID 8049060

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MEIG1 determines the manchette localization of IFT20 and IFT88, two intraflagellar transport components in male germ cells.
      Title: MEIG1 determines the manchette localization of IFT20 and IFT88, two intraflagellar transport components in male germ cells.
    2. A single amino acid mutation in the mouse MEIG1 protein disrupts a cargo transport system necessary for sperm formation.
      Title: A single amino acid mutation in the mouse MEIG1 protein disrupts a cargo transport system necessary for sperm formation.
    3. Mouse meiosis expressed gene 1 is not phosphorylated in vivo.
      Title: Mouse meiosis expressed gene 1 is not phosphorylated in vivo.
    4. MORN3 is another regulator for spermatogenesis, probably together with MEIG1.
      Title: Characterization of membrane occupation and recognition nexus repeat containing 3, meiosis expressed gene 1 binding partner, in mouse male germ cells.
    5. Studies demonstrate that MEIG1/PACRG forms a complex in the manchette and that this complex is necessary to transport cargos, such as SPAG16L, to build the sperm flagella.
      Title: A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella.
    6. Suggests that MEIG1 regulates spermiogenesis through effects in germ cells alone, and that the Meig1 gene must be active during a discrete period in spermatogenesis after which it is dispensable.
      Title: Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice.
    7. late spermiogenesis is the differentiative stage at which MEIG1's function is crucial
      Title: Meig1 deficiency causes a severe defect in mouse spermatogenesis.
    8. Findings reveal a critical role for the MEIG1/PARCG partnership in manchette structure and function and the control of spermiogenesis.
      Title: MEIG1 is essential for spermiogenesis in mice.
    9. Meig1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
      Title: Tissue expression patterns identify mouse cilia genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within manchette assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in manchette IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    meiosis-expressed gene 1 protein
    Names
    protein expressed in male leptotene and zygotene spermatocytes 278

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355205.1 → NP_001342134.1  meiosis-expressed gene 1 protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All six transcripts encode the same protein.
      Source sequence(s)
      AL732620
      Consensus CDS
      CCDS38038.1
      UniProtKB/Swiss-Prot
      Q61845
      UniProtKB/TrEMBL
      Q8CF17
      Conserved Domains (1) summary
      pfam15163
      Location:11 → 86
      Meiosis_expr; Meiosis-expressed

    2. NM_001355207.1 → NP_001342136.1  meiosis-expressed gene 1 protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six transcripts encode the same protein.
      Source sequence(s)
      AL732620
      Consensus CDS
      CCDS38038.1
      UniProtKB/Swiss-Prot
      Q61845
      UniProtKB/TrEMBL
      Q8CF17
      Related
      ENSMUSP00000110734.4, ENSMUST00000115082.10
      Conserved Domains (1) summary
      pfam15163
      Location:11 → 86
      Meiosis_expr; Meiosis-expressed

    3. NM_001355208.1 → NP_001342137.1  meiosis-expressed gene 1 protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six transcripts encode the same protein.
      Source sequence(s)
      AL732620
      Consensus CDS
      CCDS38038.1
      UniProtKB/Swiss-Prot
      Q61845
      UniProtKB/TrEMBL
      Q8CF17
      Related
      ENSMUSP00000110736.2, ENSMUST00000115084.8
      Conserved Domains (1) summary
      pfam15163
      Location:11 → 86
      Meiosis_expr; Meiosis-expressed

    4. NM_001355209.1 → NP_001342138.1  meiosis-expressed gene 1 protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six transcripts encode the same protein.
      Source sequence(s)
      AL732620
      Consensus CDS
      CCDS38038.1
      UniProtKB/Swiss-Prot
      Q61845
      UniProtKB/TrEMBL
      Q8CF17
      Related
      ENSMUSP00000110735.2, ENSMUST00000115083.8
      Conserved Domains (1) summary
      pfam15163
      Location:11 → 86
      Meiosis_expr; Meiosis-expressed

    5. NM_001355210.1 → NP_001342139.1  meiosis-expressed gene 1 protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six transcripts encode the same protein.
      Source sequence(s)
      AL732620
      Consensus CDS
      CCDS38038.1
      UniProtKB/Swiss-Prot
      Q61845
      UniProtKB/TrEMBL
      Q8CF17
      Related
      ENSMUSP00000110733.2, ENSMUST00000115081.8
      Conserved Domains (1) summary
      pfam15163
      Location:11 → 86
      Meiosis_expr; Meiosis-expressed

    6. NM_008579.4 → NP_032605.1  meiosis-expressed gene 1 protein

      See identical proteins and their annotated locations for NP_032605.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six transcripts encode the same protein.
      Source sequence(s)
      BC049538
      Consensus CDS
      CCDS38038.1
      UniProtKB/Swiss-Prot
      Q61845
      UniProtKB/TrEMBL
      Q8CF17
      Related
      ENSMUSP00000070310.8, ENSMUST00000064685.14
      Conserved Domains (1) summary
      pfam15163
      Location:11 → 86
      Meiosis_expr; Meiosis-expressed

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      3410080..3423685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61845.1 GenPept UniProtKB/Swiss-Prot:Q61845

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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