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    Ccp110 centriolar coiled coil protein 110 [ Mus musculus (house mouse) ]

    Gene ID: 101565, updated on 2-Apr-2024

    Summary

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    Official Symbol
    Ccp110provided by MGI
    Official Full Name
    centriolar coiled coil protein 110provided by MGI
    Primary source
    MGI:MGI:2141942
    See related
    Ensembl:ENSMUSG00000033904 AllianceGenome:MGI:2141942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CP110; cep110; 6330503K22Rik
    Summary
    Involved in ciliary basal body organization; negative regulation of cilium assembly; and positive regulation of cilium assembly. Located in centriole. Is expressed in embryo; inner cell mass; and olfactory epithelium. Orthologous to human CCP110 (centriolar coiled-coil protein 110). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 18.6), CNS E11.5 (RPKM 17.0) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F2; 7 63.58 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (118311740..118336247)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118712515..118737024)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane channel-like gene family 5 Neighboring gene STARR-positive B cell enhancer mm9_chr7:125849164-125849465 Neighboring gene STARR-positive B cell enhancer ABC_E4970 Neighboring gene glycerophosphodiester phosphodiesterase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4971 Neighboring gene STARR-positive B cell enhancer ABC_E1359 Neighboring gene VPS35 endosomal protein sorting factor like Neighboring gene STARR-positive B cell enhancer mm9_chr7:125909648-125909949 Neighboring gene STARR-seq mESC enhancer starr_20020 Neighboring gene predicted gene, 26147 Neighboring gene lysine rich nucleolar protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Current topics of functional links between primary cilia and cell cycle. Izawa I, et al. Cilia, 2015. PMID 26719793, Free PMC Article
    2. ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis. Song T, et al. EMBO Rep, 2022 May 4. PMID 35301795, Free PMC Article
    3. M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole. Huang N, et al. Nat Commun, 2018 Oct 30. PMID 30375385, Free PMC Article
    4. CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease. Tsang WY, et al. Dev Cell, 2008 Aug. PMID 18694559, Free PMC Article
    5. Cep97 and CP110 suppress a cilia assembly program. Spektor A, et al. Cell, 2007 Aug 24. PMID 17719545

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.
      Title: ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.
    2. CP110 is required for anchoring of basal bodies to the membrane during cilia formation. CP110 loss resulted in an abnormal distribution of core components of subdistal appendages and of recycling endosomes, which may be associated with premature extension of axonemal microtubules. CP110 has unique context-dependent functions, acting as both a suppressor and a promoter of ciliogenesis.
      Title: Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.
    3. miR-129-3p, a microRNA conserved in vertebrates, controls cilia biogenesis in cultured cells by concomitantly downregulating CP110 and repressing branched F-actin formation.
      Title: miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ciliary basal body organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ciliary basal body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of centriole elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cilium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centriolar coiled-coil protein of 110 kDa
    Names
    centrosomal protein CP110
    centrosomal protein of 110 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360793.1 → NP_001347722.1  centriolar coiled-coil protein of 110 kDa isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC152412, DV662471
      Conserved Domains (1) summary
      pfam16025
      Location:31 → 106
      CALM_bind; Calcium-dependent calmodulin binding

    2. NM_001360794.1 → NP_001347723.1  centriolar coiled-coil protein of 110 kDa isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC152412, DV662471
      UniProtKB/TrEMBL
      A0A140LJ44
      Related
      ENSMUSP00000147070.2, ENSMUST00000123178.8
      Conserved Domains (1) summary
      pfam16025
      Location:31 → 106
      CALM_bind; Calcium-dependent calmodulin binding

    3. NM_182995.2 → NP_892040.1  centriolar coiled-coil protein of 110 kDa isoform 1

      See identical proteins and their annotated locations for NP_892040.1

      Status: VALIDATED

      Source sequence(s)
      AC152412, BC053103, DV662471
      Consensus CDS
      CCDS21775.1
      UniProtKB/Swiss-Prot
      Q6A072, Q7TSH4
      Related
      ENSMUSP00000102167.2, ENSMUST00000106557.8
      Conserved Domains (1) summary
      pfam16025
      Location:29 → 131
      CALM_bind; Calcium-dependent calmodulin binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      118311740..118336247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321910.2 → XP_017177399.1  centriolar coiled-coil protein of 110 kDa isoform X1

      UniProtKB/TrEMBL
      A0A140LJ44
      Conserved Domains (1) summary
      pfam16025
      Location:31 → 106
      CALM_bind; Calcium-dependent calmodulin binding

    2. XM_006507159.4 → XP_006507222.1  centriolar coiled-coil protein of 110 kDa isoform X2

      UniProtKB/TrEMBL
      A0A140LJ44
      Conserved Domains (1) summary
      pfam16025
      Location:31 → 106
      CALM_bind; Calcium-dependent calmodulin binding
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSH4.1 GenPept UniProtKB/Swiss-Prot:Q7TSH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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