Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function.
Wu X, Jiang L, Qi H, Hu C, Jia X, Lin H, Wang S, Lin L, Zhang Y, Zheng R, Li M, Wang T, Zhao Z, Xu M, Xu Y, Chen Y, Zheng J, Bi Y, Lu J., Free PMC Article

Hsa_circ_0000073 promotes lipid synthesis of osteosarcoma through hsa-miR-1184/ FADS2 pathway.
Ren Z, Wang S, Li B, Huang H, Zhang H, Yang Z, Tian X.

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.
Mathieson I, Day FR, Barban N, Tropf FC, Brazel DM, eQTLGen Consortium, BIOS Consortium, Vaez A, van Zuydam N, Bitarello BD, Gardner EJ, Akimova ET, Azad A, Bergmann S, Bielak LF, Boomsma DI, Bosak K, Brumat M, Buring JE, Cesarini D, Chasman DI, Chavarro JE, Cocca M, Concas MP, Davey Smith G, Davies G, Deary IJ, Esko T, Faul JD, FinnGen Study, Franco O, Ganna A, Gaskins AJ, Gelemanovic A, de Geus EJC, Gieger C, Girotto G, Gopinath B, Grabe HJ, Gunderson EP, Hayward C, He C, van Heemst D, Hill WD, Hoffmann ER, Homuth G, Hottenga JJ, Huang H, Hyppӧnen E, Ikram MA, Jansen R, Johannesson M, Kamali Z, Kardia SLR, Kavousi M, Kifley A, Kiiskinen T, Kraft P, Kühnel B, Langenberg C, Liew G, Lifelines Cohort Study, Lind PA, Luan J, Mägi R, Magnusson PKE, Mahajan A, Martin NG, Mbarek H, McCarthy MI, McMahon G, Medland SE, Meitinger T, Metspalu A, Mihailov E, Milani L, Missmer SA, Mitchell P, Møllegaard S, Mook-Kanamori DO, Morgan A, van der Most PJ, de Mutsert R, Nauck M, Nolte IM, Noordam R, Penninx BWJH, Peters A, Peyser PA, Polašek O, Power C, Pribisalic A, Redmond P, Rich-Edwards JW, Ridker PM, Rietveld CA, Ring SM, Rose LM, Rueedi R, Shukla V, Smith JA, Stankovic S, Stefánsson K, Stöckl D, Strauch K, Swertz MA, Teumer A, Thorleifsson G, Thorsteinsdottir U, Thurik AR, Timpson NJ, Turman C, Uitterlinden AG, Waldenberger M, Wareham NJ, Weir DR, Willemsen G, Zhao JH, Zhao W, Zhao Y, Snieder H, den Hoed M, Ong KK, Mills MC, Perry JRB.

Placental expression of Fatty Acid Desaturases 1, 2 and 3 in selected pregnancy pathologies.
Bobiński R, Mazurek U, Zmarzly N, Ulman-Włodarz I, Dutka M, Pizon M, Pollok-Waksmańska W, Pielesz A, Hajduga M, Zimmer K, Bujok J, Pająk C, Ilczak T.

The role of fatty acid desaturase 2 in multiple tumor types revealed by bulk and single-cell transcriptomes.
Chen E, Wang C, Lv H, Yu J., Free PMC Article

The integrative panel of fatty acid desaturase-2 (FADS2) rs174583 gene polymorphism and dietary indices (DQI-I and HEI) affects cardiovascular risk factors among obese individuals.
Mahmoudinezhad M, Khosravaniardakani S, Saljoughi Badelou L, Fayyazishishavan E, Kahroba H, Farhangi MA., Free PMC Article

NSCLC Cells Resistance to PI3K/mTOR Inhibitors Is Mediated by Delta-6 Fatty Acid Desaturase (FADS2).
Colombo M, Passarelli F, Corsetto PA, Rizzo AM, Marabese M, De Simone G, Pastorelli R, Broggini M, Brunelli L, Caiola E., Free PMC Article

Association of placental fatty acid desaturase 2 (FADS2) methylation with maternal fatty acid levels in women with preeclampsia.
Dave K, Kaur L, Sundrani D, Sharma P, Bayyana S, Mehendale S, Randhir K, Chandak GR, Joshi S.

Interplay between fatty acid desaturase2 (FADS2) rs174583 genetic variant and dietary antioxidant capacity: cardio-metabolic risk factors in obese individuals.
Khodarahmi M, Javidzade P, Farhangi MA, Hashemzehi A, Kahroba H., Free PMC Article

Interaction analysis of FADS2 gene variants with chronic hepatitis B infection in Chinese patients.
Sun YH, Gao J, Shi JH, Cao SL, Yan ZP, Liu XD, Zhang HP, Li J, Guo WZ, Zhang SJ.

SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells.
Xuan Y, Wang H, Yung MM, Chen F, Chan WS, Chan YS, Tsui SK, Ngan HY, Chan KK, Chan DW., Free PMC Article

Lower polyunsaturated fatty acid levels and FADS2 expression in adult compared to neonatal keratinocytes are associated with FADS2 promotor hypermethylation.
Pararasa C, Messenger DJ, Barrett KE, Hyliands D, Talbot D, Fowler MI, Kawatra T, Gunn DA, Lim FL, Wainwright LJ, Jenkins G, Griffiths HR., Free PMC Article

FADS1 and FADS2 Gene Polymorphisms Modulate the Relationship of Omega-3 and Omega-6 Fatty Acid Plasma Concentrations in Gestational Weight Gain: A NISAMI Cohort Study.
Santana JDM, Pereira M, Carvalho GQ, Gouveia Peluzio MDC, Drumond Louro I, Santos DBD, Oliveira AM., Free PMC Article

Characterization of a novel FADS2 transcript variant: implications for D6D activity regulation in cells.
Marks KA, Fernandes MF, Diaguarachchige De Silva KH, Tomczewski MV, Stark KD, Duncan RE.

Apocryphal FADS2 activity promotes fatty acid diversification in cancer.
Young RSE, Bowman AP, Williams ED, Tousignant KD, Bidgood CL, Narreddula VR, Gupta R, Marshall DL, Poad BLJ, Nelson CC, Ellis SR, Heeren RMA, Sadowski MC, Blanksby SJ.

Influence of genetic variants in FADS2 and ELOVL2 genes on BMI and PUFAs homeostasis in children and adolescents with obesity.
Maguolo A, Zusi C, Giontella A, Miraglia Del Giudice E, Tagetti A, Fava C, Morandi A, Maffeis C.

Associations of umbilical cord fatty acid profiles and desaturase enzyme indices with birth weight for gestational age in Japanese infants.
Matsumoto A, Kawabata T, Kagawa Y, Shoji K, Kimura F, Miyazawa T, Tatsuta N, Arima T, Yaegashi N, Nakai K.

Fatty acid desaturase 2 (FADS 2) rs174575 (C/G) polymorphism, circulating lipid levels and susceptibility to type-2 diabetes mellitus.
Shetty SS, Kumari NS., Free PMC Article

Seafood, fatty acid biosynthesis genes, and multiple sclerosis susceptibility.
Langer-Gould A, Black LJ, Waubant E, Smith JB, Wu J, Gonzales EG, Shao X, Koebnick C, Lucas RM, Xiang A, Barcellos LF., Free PMC Article

FADS2 polymorphisms are associated with plasma arachidonic acid and estimated desaturase-5 activity in a cross-sectional study.
Zec MM, Stojković L, Zeković M, Pokimica B, Zivkovic M, Stankovic A, Glibetic M.

Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality.
Thomas T, Cendali F, Fu X, Gamboni F, Morrison EJ, Beirne J, Nemkov T, Antonelou MH, Kriebardis A, Welsby I, Hay A, Dziewulska KH, Busch MP, Kleinman S, Buehler PW, Spitalnik SL, Zimring JC, D'Alessandro A., Free PMC Article

Differences in erythrocyte phospholipid membrane long-chain polyunsaturated fatty acids and the prevalence of fatty acid desaturase genotype among African Americans and European Americans.
Rifkin SB, Shrubsole MJ, Cai Q, Smalley WE, Ness RM, Swift LL, Milne G, Zheng W, Murff HJ.

Is There a FADS2-Modulated Link between Long-Chain Polyunsaturated Fatty Acids in Plasma Phospholipids and Polyphenol Intake in Adult Subjects Who Are Overweight?
Zec MM, Krga I, Stojković L, Živković M, Pokimica B, Stanković A, Glibetic M., Free PMC Article

mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.
Triki M, Rinaldi G, Planque M, Broekaert D, Winkelkotte AM, Maier CR, Janaki Raman S, Vandekeere A, Van Elsen J, Orth MF, Grünewald TGP, Schulze A, Fendt SM., Free PMC Article

Association Between Genetic Variants in FADS1-FADS2 and ELOVL2 and Obesity, Lipid Traits, and Fatty Acids in Tunisian Population.
Khamlaoui W, Mehri S, Hammami S, Hammouda S, Chraeif I, Elosua R, Hammami M., Free PMC Article