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    EVA1A eva-1 homolog A, regulator of programmed cell death [ Homo sapiens (human) ]

    Gene ID: 84141, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy.

    EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy.
    Canham L, Sendac S, Diagbouga MR, Wolodimeroff E, Pirri D, Tardajos Ayllon B, Feng S, Souilhol C, Chico TJA, Evans PC, Serbanovic-Canic J., Free PMC Article

    03/31/2023
    Down-regulation of EVA1A by miR-103a-3p promotes hepatocellular carcinoma cells proliferation and migration.

    Down-regulation of EVA1A by miR-103a-3p promotes hepatocellular carcinoma cells proliferation and migration.
    Xu Q, Liao Z, Gong Z, Liu X, Yang Y, Wang Z, Yang W, Hou L, Yang J, Song J, Liu W, Wang B, Hua J, Pu M, Li N., Free PMC Article

    11/5/2022
    The Degradation of TMEM166 by Autophagy Promotes AMPK Activation to Protect SH-SY5Y Cells Exposed to MPP().

    The Degradation of TMEM166 by Autophagy Promotes AMPK Activation to Protect SH-SY5Y Cells Exposed to MPP().
    Liao Z, Gong Z, Wang Z, Yang W, Liu W, Hou L, Liu X, Hua J, Wang B, Li N., Free PMC Article

    10/8/2022
    Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b.

    Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b.
    Li J, Chen Y, Gao J, Chen Y, Zhou C, Lin X, Liu C, Zhao M, Xu Y, Ji L, Jiang Z, Pan B, Zheng L.

    12/4/2021
    TMEM166 inhibits cell proliferation, migration and invasion in hepatocellular carcinoma via upregulating TP53.

    TMEM166 inhibits cell proliferation, migration and invasion in hepatocellular carcinoma via upregulating TP53.
    Yang J, Wang B, Xu Q, Yang Y, Hou L, Yin K, Guo Q, Hua Y, Zhang L, Li Y, Zhang J, Li N.

    07/17/2021
    Eva-1 homolog A promotes papillary thyroid cancer progression and epithelial-mesenchymal transition via the Hippo signalling pathway.

    Eva-1 homolog A promotes papillary thyroid cancer progression and epithelial-mesenchymal transition via the Hippo signalling pathway.
    Lin BY, Wen JL, Zheng C, Lin LZ, Chen CZ, Qu JM., Free PMC Article

    06/19/2021
    Transmembrane Protein 166 and its Significance.

    Transmembrane Protein 166 and its Significance.
    Yang Y, Zhou L, Xue F, An L, Jin M, Li L.

    06/12/2021
    Eva1a inhibits NLRP3 activation to reduce liver ischemia-reperfusion injury via inducing autophagy in kupffer cells.

    Eva1a inhibits NLRP3 activation to reduce liver ischemia-reperfusion injury via inducing autophagy in kupffer cells.
    Wang Z, Han S, Chen X, Li X, Xia N, Pu L.

    04/24/2021
    Myc/Max dependent intronic long antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner.

    Myc/Max dependent intronic long antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner.
    Niehus SE, Allister AB, Hoffmann A, Wiehlmann L, Tamura T, Tran DDH., Free PMC Article

    11/21/2020
    results suggest that miR-125b plays a role in the resistance of HCC cells to chemotherapy via a mechanism involving the downregulation of EVA1A-mediated autophagy.

    MicroRNA-125b reverses oxaliplatin resistance in hepatocellular carcinoma by negatively regulating EVA1A mediated autophagy.
    Ren WW, Li DD, Chen X, Li XL, He YP, Guo LH, Liu LN, Sun LP, Zhang XP., Free PMC Article

    11/9/2019
    EVA1A interacts with the WD repeats of ATG16L1 through its C-terminal and promotes ATG12-ATG5/ATG16L1 complex recruitment to the autophagic membrane and enhances the formation of the autophagosome.

    TMEM166/EVA1A interacts with ATG16L1 and induces autophagosome formation and cell death.
    Hu J, Li G, Qu L, Li N, Liu W, Xia D, Hongdu B, Lin X, Xu C, Lou Y, He Q, Ma D, Chen Y., Free PMC Article

    09/30/2017
    Low EVA1A expression is associated with glioblastoma.

    EVA1A inhibits GBM cell proliferation by inducing autophagy and apoptosis.
    Shen X, Kan S, Liu Z, Lu G, Zhang X, Chen Y, Bai Y.

    06/3/2017
    The adenovirus-mediated increase of FAM176A inhibited the growth of the tumor cells.

    Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non-small cell lung cancer cells.
    Xie H, Hu J, Pan H, Lou Y, Lv P, Chen Y., Free PMC Article

    10/25/2014
    TMEM166 expression was widely down-regulated in the cancer tissues.

    Expression of TMEM166 protein in human normal and tumor tissues.
    Xu D, Yang F, He H, Hu J, Lv X, Ma D, Chen YY.

    06/14/2014
    Low TMEM166 mRNA and protein expression is associated with esophageal squamous cell carcinoma.

    Transmembrane protein 166 expression in esophageal squamous cell carcinoma in Xinjiang, China.
    Sun W, Ma XM, Bai JP, Zhang GQ, Zhu YJ, Ma HM, Guo H, Chen YY, Ding JB.

    04/20/2013
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    TMEM166 is a novel regulator involved in both autophagy and apoptosis.

    TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis.
    Wang L, Yu C, Lu Y, He P, Guo J, Zhang C, Song Q, Ma D, Shi T, Chen Y.

    01/21/2010
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