| Apoptosis-inducing factor plays a role in the pathogenesis of hepatic and renal injury during cholestasis. | Apoptosis-inducing factor plays a role in the pathogenesis of hepatic and renal injury during cholestasis.
Ghanbarinejad V, Jamshidzadeh A, Khalvati B, Farshad O, Li H, Shi X, Chen Y, Ommati MM, Heidari R. | 12/18/2021 |
| Expression pattern of apoptosis-inducing factor in the kidneys of streptozotocin-induced diabetic rats. | Expression pattern of apoptosis-inducing factor in the kidneys of streptozotocin-induced diabetic rats.
Kostic S, Hauke T, Ghahramani N, Filipovic N, Vukojevic K. | 09/4/2021 |
| CaMK II -induced Drp1 phosphorylation contributes to blue light-induced AIF-mediated necroptosis in retinal R28 cells. | CaMK II -induced Drp1 phosphorylation contributes to blue light-induced AIF-mediated necroptosis in retinal R28 cells.
Yang D, Rong R, Yang R, You M, Wang M, Li H, Ji D. | 08/28/2021 |
| Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/reperfusion rats. | Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/reperfusion rats.
Li WH, Yang YL, Cheng X, Liu M, Zhang SS, Wang YH, Du GH. | 06/5/2021 |
| AIF knockdown induce apoptosis and mitochondrial dysfunction in cochlear spiral ganglion neurons in vitro. | AIF knockdown induce apoptosis and mitochondrial dysfunction in cochlear spiral ganglion neurons in vitro.
Zong L, Zhao J, Wu W, Wang J, Huang D, Liu M., Free PMC Article | 02/6/2021 |
| Involvement of the biogenic active amine agmatine in mitochondrial membrane permeabilization and release of pro-apoptotic factors. | Involvement of the biogenic active amine agmatine in mitochondrial membrane permeabilization and release of pro-apoptotic factors.
Martinis P, Grancara S, Kanamori Y, García-Argáez AN, Pacella E, Dalla Via L, Toninello A, Agostinelli E. | 11/21/2020 |
| Study provides evidence that RIP3 combined with AIF and translocated into the nucleus after cerebral ischemia/reperfusion (I/R) injury inducing ischemic neuronal DNA degradation and programmed necrosis. | RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF.
Xu Y, Wang J, Song X, Qu L, Wei R, He F, Wang K, Luo B., Free PMC Article | 05/26/2018 |
| Results suggest that apoptosis-inducing factor nuclear translocation and neuronal cell death are associated with Iduna loss after severe hypoxic-ischemic in the immature brain. | Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia.
Yang X, Cheng J, Gao Y, Ding J, Ni X. | 11/11/2017 |
| investigated the mechanobiological roles of caspase-9 and Apoptosis Inducing Factor (AIF), two important components in mitochondrial pathway, in stretch-induced apoptosis of myoblasts | Apoptosis Inducing Factor Is Involved in Stretch-Induced Apoptosis of Myoblast via a Caspase-9 Independent Pathway.
Wang F, Wei ZL, Sun XR, Zhang Q, Zhang CX, Jiang WX, Yan X, Liu JN, Yuan X. | 11/4/2017 |
| These data indicates that Drp1 mediates compression-induced programmed necrosis of NP cells by promoting mitochondrial translocation of p53 and nuclear translocation of AIF. | Drp1 mediates compression-induced programmed necrosis of rat nucleus pulposus cells by promoting mitochondrial translocation of p53 and nuclear translocation of AIF.
Lin H, Zhao L, Ma X, Wang BC, Deng XY, Cui M, Chen SF, Shao ZW. | 06/24/2017 |
| involved in streptomycin ototoxicity by translocation from mitochondria to cytosol and nucleus of cochlear hair cells | PARP-1-modulated AIF translocation is involved in streptomycin-induced cochlear hair cell death.
Song Y, Fan Z, Bai X, Liu W, Han Y, Xu L, Wang M, Li J, Zheng Q, Zhang D, Wang H., Free PMC Article | 02/18/2017 |
| Data indicate that mitochondrial apoptosis-inducing factor (AIF) silencing prevents doxorubicin toxicity on cardiomyoblasts. | Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts.
Moreira AC, Branco AF, Sampaio SF, Cunha-Oliveira T, Martins TR, Holy J, Oliveira PJ, Sardão VA. | 05/2/2015 |
| Peroxynitrite can trigger apoptosis in spiral ganglion neurons associated with mitochondrial AIF and endonuclease G intranuclear localization. | Intranuclear localization of apoptosis-inducing factor and endonuclease G involves in peroxynitrite-induced apoptosis of spiral ganglion neurons.
Liu W, Fan Z, Han Y, Zhang D, Li J, Wang H. | 08/31/2013 |
| ERp57 forms complexes with mitochondrial mu-calpain, and ERp57-associated mitochondrial mu-calpain cleaves apoptosis-inducing factor to a truncated form. | ERp57-associated mitochondrial μ-calpain truncates apoptosis-inducing factor.
Ozaki T, Yamashita T, Ishiguro S. | 12/12/2011 |
| In vivo inhibition of caspases and poly(ADP-ribose)polymerase-1, an upstream regulator of AIF release and calpain, proves the central role of the AIF-dependent pathway in lipopolysasccharide-induced nigral dopaminergic cell death. | Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: evidence in Parkinson's disease patients.
Burguillos MA, Hajji N, Englund E, Persson A, Cenci AM, Machado A, Cano J, Joseph B, Venero JL. | 10/1/2011 |
| The anti-apoptotic function of Hsp70 occurs through the inhibition of AIF-induced apoptosis by blocking the mitochondria to nucleus translocation of AIF | Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusion.
Choudhury S, Bae S, Ke Q, Lee JY, Kim J, Kang PM., Free PMC Article | 07/16/2011 |
| Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by alpha-tocopherol and MEK inhibition. | Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by alpha-tocopherol and MEK inhibition.
Kondo K, Obitsu S, Ohta S, Matsunami K, Otsuka H, Teshima R., Free PMC Article | 05/31/2010 |
| caspase inhibition inhibited the release of AIF; this suggests that there can be cross-talk between the caspase-dependent and the ostensibly caspase-independent pathway in neuronal apoptosis | Evidence for caspase effects on release of cytochrome c and AIF in a model of ischemia in cortical neurons.
Singh MH, Brooke SM, Zemlyak I, Sapolsky RM., Free PMC Article | 04/19/2010 |
| mitochondrial m-calpain plays a role in the release of tAIF from mitochondria by cleaving VDAC, and tAIF is released through VDAC-Bax pores. | Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria.
Ozaki T, Yamashita T, Ishiguro S. | 03/1/2010 |
| A caspase-dependent, apoptotic pathway is important for non-hypertrophic cardiomyocytes (N-CMs) death, whereas a caspase-independent, AIF-mediated pathway plays a critical role in Hypertrophic cardiomyocyte (H-CM). | Role of AIF in cardiac apoptosis in hypertrophic cardiomyocytes from Dahl salt-sensitive rats.
Choudhury S, Bae S, Kumar SR, Ke Q, Yalamarti B, Choi JH, Kirshenbaum LA, Kang PM., Free PMC Article | 02/22/2010 |
| Data show that restriction of dietary amino acids different from methionine decreases mitochondrial protein oxidative modification and AIF, and increases SIRT1, in rat liver. | Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver.
Caro P, Gomez J, Sanchez I, Garcia R, López-Torres M, Naudí A, Portero-Otin M, Pamplona R, Barja G. | 01/21/2010 |
| Cadmium-induced apoptosis is mediated by the translocation of AIF to the nucleus in rat testes. | Cadmium-induced apoptosis is mediated by the translocation of AIF to the nucleus in rat testes.
Kim J, Soh J. | 01/21/2010 |
| The inhibition of Rho-kinase reduced cell apoptosis in I/R in vivo via suppression of JNK-mediated AIF translocation. | Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation.
Zhang J, Li XX, Bian HJ, Liu XB, Ji XP, Zhang Y. | 01/21/2010 |
| Data suggest that nuclear translocation of apoptosis inducing factor could underlie cell death, while fragmentation of caspase 3 could be associated with the morphological changes found in hypothalamic astrocytes of diabetic rats. | Death of hypothalamic astrocytes in poorly controlled diabetic rats is associated with nuclear translocation of apoptosis inducing factor.
García-Cáceres C, Lechuga-Sancho A, Argente J, Frago LM, Chowen JA. | 01/21/2010 |
| An apoptosis-inducing factor (AIF)-related pathway is an essential target of PEDF-mediated neuroprotection. | Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration.
Murakami Y, Ikeda Y, Yonemitsu Y, Onimaru M, Nakagawa K, Kohno R, Miyazaki M, Hisatomi T, Nakamura M, Yabe T, Hasegawa M, Ishibashi T, Sueishi K., Free PMC Article | 01/21/2010 |