| Inhibition of UBA52 induces autophagy via EMC6 to suppress hepatocellular carcinoma tumorigenesis and progression. | Inhibition of UBA52 induces autophagy via EMC6 to suppress hepatocellular carcinoma tumorigenesis and progression.
Tong L, Zheng X, Wang T, Gu W, Shen T, Yuan W, Wang S, Xing S, Liu X, Zhang C, Zhang C., Free PMC Article | 03/7/2024 |
| EMC6 regulates acinar apoptosis via APAF1 in acute and chronic pancreatitis. | EMC6 regulates acinar apoptosis via APAF1 in acute and chronic pancreatitis.
Tan JH, Cao RC, Zhou L, Zhou ZT, Chen HJ, Xu J, Chen XM, Jin YC, Lin JY, Qi ZC, Zeng JL, Li SJ, Luo M, Hu GD, Jin J, Zhang GW., Free PMC Article | 05/1/2021 |
| Adenovirus-mediated ectopic overexpression of EMC6 (Ad5-EMC6) decreases the activity of ERK1/2, down-regulates the levels of BCL-2 and increases the ratio of BAX/BCL-2. Ad5-EMC6 mediates anti-tumor activity through the mitochondrial apoptosis pathway. Ad5-EMC6 enhances the sensitivity of gastric cancer cells to the etoposide. | Ad5-EMC6 mediates antitumor activity in gastric cancer cells through the mitochondrial apoptosis pathway.
Li R, Wang X, Zhang X, Yu J, Feng J, Lv P, Lou Y, Chen Y. | 06/27/2020 |
| The expression level of EMC-6 is significantly elevated in cervical cancer, without significant correlation with Beclin1 and Rab5a. | Expression levels and roles of EMC-6, Beclin1, and Rab5a in the cervical cancer.
Shen MX, Ding JB. | 07/14/2018 |
| This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored. | ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer.
Wang X, Xia Y, Xu C, Lin X, Xue P, Zhu S, Bai Y, Chen Y., Free PMC Article | 05/12/2018 |
| Endoplasmic membrane protein complex subunit 6 (EMC6) interacted with both RAB5A and BECN1/Beclin 1 and colocalized with the omegasome marker ZFYVE1/DFCP1. | A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy.
Li Y, Zhao Y, Hu J, Xiao J, Qu L, Wang Z, Ma D, Chen Y., Free PMC Article | 07/13/2013 |