| Integrative Analyses Followed by Functional Characterization Reveal TMEM180 as a Schizophrenia Risk Gene. | Integrative Analyses Followed by Functional Characterization Reveal TMEM180 as a Schizophrenia Risk Gene.
Wang JY, Li XY, Li HJ, Liu JW, Yao YG, Li M, Xiao X, Luo XJ., Free PMC Article | 02/12/2022 |
| Using a homology model of TMEM180, we experimentally determined that the protein has 12 transmembrane domains, and that its N-terminal and C-termini are exposed extracellularly. Moreover, we found that the putative cation-binding site of TMEM180 is conserved among orthologs, and that its position is similar to that of melibiose transporter MelB. | Topological analysis of TMEM180, a newly identified membrane protein that is highly expressed in colorectal cancer cells.
Anzai T, Matsumura Y. | 07/18/2020 |
| The allele G of rs2001389 weakened the binding activity with CTCF, and it was related to the lower expression of a putative antioncogene MFSD13A whose knockdown promoted proliferation of PC cells. By integrating analysis on multiomics data, association studies and functional assays, we proposed that the common variant rs2001389 and the gene MFSD13A might be genetic modifiers of PC tumorigenesis. | A functional variant in the boundary of a topological association domain is associated with pancreatic cancer risk.
Mei S, Ke J, Tian J, Ying P, Yang N, Wang X, Zou D, Peng X, Yang Y, Zhu Y, Gong Y, Zhong R, Chang J, Miao X. | 02/1/2020 |