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T T, brachyury homolog (mouse) [ Homo sapiens (human) ]

Gene ID: 6862, updated on 1-Feb-2015

GeneRIFs: Gene References Into Functions

GeneRIFPubMed TitleDate
Brachyury expression may useful for the differential diagnosis of renal hemangioblastoma from other neoplastic histological mimickers. [Review]

Brachyury: a diagnostic marker for the differential diagnosis of chordoma and hemangioblastoma versus neoplastic histological mimickers.
Barresi V, Ieni A, Branca G, Tuccari G., Free PMC Article

01/24/2015
Brachyury knockdown reduces invasiveness and chemoresistance and radioresistance of cancer stem cells in vivo.

Knockdown of the T-box transcription factor Brachyury increases sensitivity of adenoid cystic carcinoma cells to chemotherapy and radiation in vitro: implications for a new therapeutic principle.
Kobayashi Y, Sugiura T, Imajyo I, Shimoda M, Ishii K, Akimoto N, Yoshihama N, Mori Y., Free PMC Article

11/29/2014
Importance of the T gene in the pathogenesis of both familial and sporadic chordoma.

Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma.
Kelley MJ, Shi J, Ballew B, Hyland PL, Li WQ, Rotunno M, Alcorta DA, Liebsch NJ, Mitchell J, Bass S, Roberson D, Boland J, Cullen M, He J, Burdette L, Yeager M, Chanock SJ, Parry DM, Goldstein AM, Yang XR.

11/22/2014
Activated brachury is associated with chordoma.

The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival.
Hu Y, Mintz A, Shah SR, Quinones-Hinojosa A, Hsu W.

09/27/2014
The level of brachyury expression in breast cancer cells was positively associated with their ability to invade the extracellular matrix, efficiently form mammospheres in vitro, and resist the cytotoxic effect of docetaxel

Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis.
Palena C, Roselli M, Litzinger MT, Ferroni P, Costarelli L, Spila A, Cavaliere F, Huang B, Fernando RI, Hamilton DH, Jochems C, Tsang KY, Cheng Q, Lyerly HK, Schlom J, Guadagni F.

09/20/2014
Multiple abnormalities, consisting of sacral agenesis, abnormal ossification of the vertebral bodies and a persistent notochordal canal, are associated with mutations in the T (brachyury) gene.

Mutations in the T (brachyury) gene cause a novel syndrome consisting of sacral agenesis, abnormal ossification of the vertebral bodies and a persistent notochordal canal.
Postma AV, Alders M, Sylva M, Bilardo CM, Pajkrt E, van Rijn RR, Schulte-Merker S, Bulk S, Stefanovic S, Ilgun A, Barnett P, Mannens MM, Moorman AF, Oostra RJ, van Maarle MC.

09/13/2014
High expression of Brachyury gene is associated with lung carcinoma.

Expression of Brachyury gene is a significant prognostic factor for primary lung carcinoma.
Haro A, Yano T, Kohno M, Yoshida T, Koga T, Okamoto T, Takenoyama M, Maehara Y.

08/30/2014
We report two cases of recurrent EAC confirmed by the expression of brachyury arising from the distal femur and distal tibia and describe the imaging findings from radiography and MRI at initial diagnosis and at recurrence.

Recurrent skeletal extra-axial chordoma confirmed with brachyury: imaging features and review of the literature.
Lantos JE, Agaram NP, Healey JH, Hwang S.

04/26/2014
Common variants of PAX3 and T are associated with spina bifida.

Exon sequencing of PAX3 and T (brachyury) in cases with spina bifida.
Agopian AJ, Bhalla AD, Boerwinkle E, Finnell RH, Grove ML, Hixson JE, Shimmin LC, Sewda A, Stuart C, Zhong Y, Zhu H, Mitchell LE., Free PMC Article

04/26/2014
results show that Brachyury expression is enhanced during TGF-beta1-induced epithelial-mesenchymal transition in human cancer cell lines and that a positive feedback loop is established between Brachyury and TGF-beta1 in mesenchymal-like tumor cells

An autocrine loop between TGF-β1 and the transcription factor brachyury controls the transition of human carcinoma cells into a mesenchymal phenotype.
Larocca C, Cohen JR, Fernando RI, Huang B, Hamilton DH, Palena C., Free PMC Article

04/5/2014
Brachyury expression may attenuate cell cycle progression, enabling tumor cells to become less susceptible to chemotherapy and radiation in human carcinomas.

The embryonic transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to conventional antitumor therapies.
Huang B, Cohen JR, Fernando RI, Hamilton DH, Litzinger MT, Hodge JW, Palena C., Free PMC Article

03/1/2014
The results of this study suggested that brachyury-negative chordomas are biologically distinct from brachyury-positive chordomas and that T/brachyury might be an appropriate molecular therapeutic target for chordoma.

Molecular and clinical risk factors for recurrence of skull base chordomas: gain on chromosome 2p, expression of brachyury, and lack of irradiation negatively correlate with patient prognosis.
Kitamura Y, Sasaki H, Kimura T, Miwa T, Takahashi S, Kawase T, Yoshida K.

10/26/2013
heterochromatin-specific nonhistone chromosomal protein HP-1

Malignant tumors with clear cell morphology: a comparative immunohistochemical study with renal cell carcinoma antibody, Pax8, steroidogenic factor 1, and brachyury.
Clayton EF, Ziober A, Yao Y, Bing Z.

08/31/2013
Our findings present clinical evidence for an important role of Brachyury in EMT in oral SCC, and suggest that Brachyury and EMT patterns are useful prognostic markers.

T-box transcription factor Brachyury expression is correlated with epithelial-mesenchymal transition and lymph node metastasis in oral squamous cell carcinoma.
Imajyo I, Sugiura T, Kobayashi Y, Shimoda M, Ishii K, Akimoto N, Yoshihama N, Kobayashi I, Mori Y., Free PMC Article

04/20/2013
Data show a combination of only five genes (-BCL6, T (BRACHYURY), c-MYC, MITF and BAF60C (SMARCD3) rapidly and efficiently convert postnatal chorion and decidual cells into chondrocytes.

Placenta to cartilage: direct conversion of human placenta to chondrocytes with transformation by defined factors.
Ishii R, Kami D, Toyoda M, Makino H, Gojo S, Ishii T, Umezawa A., Free PMC Article

03/9/2013
Functional significance of Brachyury in the developmental program of hematopoietic differentiation from embryonic stem cells.

Activin A promotes hematopoietic fated mesoderm development through upregulation of brachyury in human embryonic stem cells.
Cerdan C, McIntyre BA, Mechael R, Levadoux-Martin M, Yang J, Lee JB, Bhatia M., Free PMC Article

03/2/2013
An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.

An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.
Nelson AC, Pillay N, Henderson S, Presneau N, Tirabosco R, Halai D, Berisha F, Flicek P, Stemple DL, Stern CD, Wardle FC, Flanagan AM.

01/12/2013
Propose the use of brachyury as an additional helpful immunohistochemical marker to resolve the differential diagnosis of hemangioblastoma and histologic mimics.

Expression of brachyury in hemangioblastoma: potential use in differential diagnosis.
Barresi V, Vitarelli E, Branca G, Antonelli M, Giangaspero F, Barresi G.

09/8/2012
Genom-wide association identifies the T gene as a novel asthma pharmacogenetic locus.

Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
Tantisira KG, Damask A, Szefler SJ, Schuemann B, Markezich A, Su J, Klanderman B, Sylvia J, Wu R, Martinez F, Boushey HA, Chinchilli VM, Mauger D, Weiss ST, Israel E, SHARP Investigators., Free PMC Article

09/1/2012
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity.
Pereira LA, Wong MS, Lim SM, Sides A, Stanley EG, Elefanty AG., Free PMC Article

07/21/2012
BRACHYURY may regulate NANOG in mesenchymal-like CRC cells to impose a 'plastic-state', allowing competence of cells to respond to signals prompting invasion or metastasis.

BRACHYURY confers cancer stem cell characteristics on colorectal cancer cells.
Sarkar D, Shields B, Davies ML, Müller J, Wakeman JA.

03/17/2012
Loss of p27(Kip)(1) causes an elongated/scatter cell-like phenotype involving up-regulation of Brachyury and Twist gene expression.

The cell cycle inhibitor p27Kip¹ controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist.
Menchón C, Edel MJ, Izpisua Belmonte JC., Free PMC Article

03/17/2012
BRA was necessary for and preceded CDX2 expression.

BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.
Bernardo AS, Faial T, Gardner L, Niakan KK, Ortmann D, Senner CE, Callery EM, Trotter MW, Hemberger M, Smith JC, Bardwell L, Moffett A, Pedersen RA., Free PMC Article

03/17/2012
DeltaNP63 is not expressed and is therefore rarely, if ever, a transcriptional regulator of brachyury in human osteosarcomas and chordomas.

P63 does not regulate brachyury expression in human chordomas and osteosarcomas.
Pillay N, Amary FM, Berisha F, Tirabosco R, Flanagan AM.

03/10/2012
Brachyury expression predicts poor prognosis at early stages of colorectal cancer

Brachyury expression predicts poor prognosis at early stages of colorectal cancer.
Kilic N, Feldhaus S, Kilic E, Tennstedt P, Wicklein D, Wasielewski Rv, Viebahn C, Kreipe H, Schumacher U.

11/19/2011
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