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    METTL14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit [ Homo sapiens (human) ]

    Gene ID: 57721, updated on 16-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition.

    Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition.
    Liao MC, Lo CS, Pang YC, Yang WX, Su K, Zhao XP, Miyata KN, Peng J, Ingelfinger JR, Chan JSD, Zhang SL.

    04/16/2024
    Lnc-PLCB1 is stabilized by METTL14 induced m6A modification and inhibits Helicobacter pylori mediated gastric cancer by destabilizing DDX21.

    Lnc-PLCB1 is stabilized by METTL14 induced m6A modification and inhibits Helicobacter pylori mediated gastric cancer by destabilizing DDX21.
    Chang M, Cui X, Sun Q, Wang Y, Liu J, Sun Z, Ren J, Sun Y, Han L, Li W.

    04/12/2024
    METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.

    METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.
    Lu W, Yang X, Zhong W, Chen G, Guo X, Ye Q, Xu Y, Qi Z, Ye Y, Zhang J, Wang Y, Wang X, Wang S, Zhao Q, Zeng W, Huang J, Ma H, Xie J., Free PMC Article

    03/19/2024
    METTL14-Mediated m6a Modification of CDKN2A Promotes the Development of Retinoblastoma by Inhibiting the p53 Pathway.

    METTL14-Mediated m6a Modification of CDKN2A Promotes the Development of Retinoblastoma by Inhibiting the p53 Pathway.
    Chen J, Zeng B.

    03/1/2024
    Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review).

    Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review).
    Shao C, Han Y, Huang Y, Zhang Z, Gong T, Zhang Y, Tian X, Fang M, Han X, Li M., Free PMC Article

    02/26/2024
    METTL14 promotes IL-6-induced viability, glycolysis and inflammation in HaCaT cells via the m6A modification of TRIM27.

    METTL14 promotes IL-6-induced viability, glycolysis and inflammation in HaCaT cells via the m6A modification of TRIM27.
    Chen Y, Xiang Y, Miao X, Kuai L, Ding X, Ma T, Li B, Fan B., Free PMC Article

    02/9/2024
    Glycolysis Induced by METTL14 Is Essential for Macrophage Phagocytosis and Phenotype in Cervical Cancer.

    Glycolysis Induced by METTL14 Is Essential for Macrophage Phagocytosis and Phenotype in Cervical Cancer.
    Wang B, Mao Z, Ye J, Jiao X, Zhang T, Wang Q, Han S, Zhang Y, Wang C, Dong T, Cui B., Free PMC Article

    02/8/2024
    METTL14 drives growth and metastasis of non-small cell lung cancer by regulating pri-miR-93-5p maturation and TXNIP expression.

    METTL14 drives growth and metastasis of non-small cell lung cancer by regulating pri-miR-93-5p maturation and TXNIP expression.
    Qian S, Liu J, Liao W, Wang F.

    02/7/2024
    METTL14-mediated lncRNA XIST silencing alleviates GDM progression by facilitating trophoblast cell proliferation and migration via the miR-497-5p/FOXO1 axis.

    METTL14-mediated lncRNA XIST silencing alleviates GDM progression by facilitating trophoblast cell proliferation and migration via the miR-497-5p/FOXO1 axis.
    Li Y, Liu Y, Yao X, Wang H, Shi Z, He M.

    02/6/2024
    PRMT3-Mediated Arginine Methylation of METTL14 Promotes Malignant Progression and Treatment Resistance in Endometrial Carcinoma.

    PRMT3-Mediated Arginine Methylation of METTL14 Promotes Malignant Progression and Treatment Resistance in Endometrial Carcinoma.
    Wang Y, Wang C, Guan X, Ma Y, Zhang S, Li F, Yin Y, Sun Z, Chen X, Yin H., Free PMC Article

    01/4/2024
    CircMETTL14(11)S upregulated METTL14 and induced CXCR4 to aggravate endothelial inflammation and atherosclerosis.

    CircMETTL14(11)S upregulated METTL14 and induced CXCR4 to aggravate endothelial inflammation and atherosclerosis.
    Kang P, Dong P.

    01/4/2024
    Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption.

    Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption.
    Yang JG, Sun B, Wang Z, Li X, Gao JH, Qian JJ, Li J, Wei WJ, Zhang P, Wang W., Free PMC Article

    11/29/2023
    METTL14-upregulated miR-6858 triggers cell apoptosis in keratinocytes of oral lichen planus through decreasing GSDMC.

    METTL14-upregulated miR-6858 triggers cell apoptosis in keratinocytes of oral lichen planus through decreasing GSDMC.
    Wang X, Li S, Song H, Ding Y, Gao R, Shi X, Li R, Ge X., Free PMC Article

    11/20/2023
    LncRNA THRIL, transcriptionally activated by AP-1 and stabilized by METTL14-mediated m6A modification, accelerates LPS-evoked acute injury in alveolar epithelial cells.

    LncRNA THRIL, transcriptionally activated by AP-1 and stabilized by METTL14-mediated m6A modification, accelerates LPS-evoked acute injury in alveolar epithelial cells.
    Shi Q, Li Z, Dong Y, Yang G, Li M.

    09/27/2023
    METTL14 inhibits malignant progression of oral squamous cell carcinoma by targeting the autophagy-related gene RB1CC1 in an m6A-IGF2BP2-dependent manner.

    METTL14 inhibits malignant progression of oral squamous cell carcinoma by targeting the autophagy-related gene RB1CC1 in an m6A-IGF2BP2-dependent manner.
    Liang J, Cai H, Hou C, Song F, Jiang Y, Wang Z, Qiu D, Zhu Y, Wang F, Yu D, Hou J., Free PMC Article

    09/8/2023
    METTL14 represses osteoclast formation to ameliorate osteoporosis via enhancing GPX4 mRNA stability.

    METTL14 represses osteoclast formation to ameliorate osteoporosis via enhancing GPX4 mRNA stability.
    Deng M, Luo J, Cao H, Li Y, Chen L, Liu G.

    08/10/2023
    METTL14-mediated RNA methylation in digestive system tumors.

    METTL14‑mediated RNA methylation in digestive system tumors.
    Hu J, Lin H, Wang C, Su Q, Cao B., Free PMC Article

    08/7/2023
    METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.

    METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.
    Hou X, Li Y, Song J, Peng L, Zhang W, Liu R, Yuan H, Feng T, Li J, Li W, Zhu C., Free PMC Article

    08/4/2023
    METTL14 is decreased and regulates m[6] A modification of alpha-synuclein in Parkinson's disease.

    METTL14 is decreased and regulates m(6) A modification of α-synuclein in Parkinson's disease.
    He H, Zhang Q, Liao J, Lei J, Luo M, Huang J, Chen M, Shen Y, Wang J, Xu P, Xiao Y.

    07/26/2023
    Mechanism of METTL14 and m6A modification of lncRNA MALAT1 in the proliferation of oral squamous cell carcinoma cells.

    Mechanism of METTL14 and m6A modification of lncRNA MALAT1 in the proliferation of oral squamous cell carcinoma cells.
    Li J, Momen-Heravi F, Wu X, He K.

    06/15/2023
    LncRNA UCA1 promotes keratinocyte-driven inflammation via suppressing METTL14 and activating the HIF-1alpha/NF-kappaB axis in psoriasis.

    LncRNA UCA1 promotes keratinocyte-driven inflammation via suppressing METTL14 and activating the HIF-1α/NF-κB axis in psoriasis.
    Hu Y, Lei L, Jiang L, Zeng H, Zhang Y, Fu C, Guo H, Dong Y, Ouyang Y, Zhang X, Huang J, Zeng Q, Chen J., Free PMC Article

    04/24/2023
    METTL14 Promotes Oral Squamous Cell Carcinoma Progression by Regulating the mRNA and m6A Levels of CALD1.

    METTL14 Promotes Oral Squamous Cell Carcinoma Progression by Regulating the mRNA and m6A Levels of CALD1.
    Chen R, Zhang S, Li H, Yang M, Lu Y, Zhang X.

    04/7/2023
    METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.

    METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.
    Sun K, Chen L, Li Y, Huang B, Yan Q, Wu C, Lai Q, Fang Y, Cai J, Liu Y, Chen J, Wang X, Zhu Y, Dong S, Tan J, Li A, Liu S, Zhang Y., Free PMC Article

    02/24/2023
    RNA m6A methyltransferase METTL14 promotes the procession of non-small cell lung cancer by targeted CSF1R.

    RNA m6A methyltransferase METTL14 promotes the procession of non-small cell lung cancer by targeted CSF1R.
    Ren S, Xiao Y, Yang L, Hu Y., Free PMC Article

    02/4/2023
    Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis.

    Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis.
    Zhang TP, Li R, Wang LJ, Huang Q, Li HM., Free PMC Article

    12/31/2022
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