| palmitoylation is a prerequisite for the function of MCOLN3/TRPML3 as a Ca(2+) channel in autophagosome formation. | Palmitoylation controls trafficking of the intracellular Ca(2+) channel MCOLN3/TRPML3 to regulate autophagy.
Kim SW, Kim DH, Park KS, Kim MK, Park YM, Muallem S, So I, Kim HJ., Free PMC Article | 03/7/2020 |
| The work elucidates the molecular architecture and provides insights into how multiple ligands regulate TRPML1 and TRPML3. (Review) | The regulatory mechanism of mammalian TRPMLs revealed by cryo-EM.
Schmiege P, Fine M, Li X., Free PMC Article | 06/1/2019 |
| these results suggest that TRPML3 plays a role in autophagosome maturation through the interaction with GATE16, by providing Ca(2+) in the fusion process. | The Ca2+ channel TRPML3 specifically interacts with the mammalian ATG8 homologue GATE16 to regulate autophagy.
Choi S, Kim HJ. | 05/10/2014 |
| TRPML3 and TRPV5 heteromers could have a biological function | A novel ion channel formed by interaction of TRPML3 with TRPV5.
Guo Z, Grimm C, Becker L, Ricci AJ, Heller S., Free PMC Article | 08/31/2013 |
| Negatively charged amino acids in the extracellular loops of TRPML3 may interfere with the observed sodium inhibition. | Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules.
Grimm C, Jörs S, Guo Z, Obukhov AG, Heller S., Free PMC Article | 09/15/2012 |
| TRPML 1, 2 and 3 assemblies regulated cell viability and starvation-induced autophagy. | Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy.
Zeevi DA, Lev S, Frumkin A, Minke B, Bach G., Free PMC Article | 01/1/2011 |
| analysis of the TRPML3 channel pore and its stable expansion by the Varitint-Waddler-causing mutation | Properties of the TRPML3 channel pore and its stable expansion by the Varitint-Waddler-causing mutation.
Kim HJ, Yamaguchi S, Li Q, So I, Muallem S., Free PMC Article | 06/28/2010 |
| Data show that TRPMLs form distinct functional channel complexes. | Functional multimerization of mucolipin channel proteins.
Curcio-Morelli C, Zhang P, Venugopal B, Charles FA, Browning MF, Cantiello HF, Slaugenhaupt SA. | 01/21/2010 |
| Results show that mucolipin 3 is a novel calcium channel that plays a crucial role in the regulation of cargo trafficking along the endosomal pathway. | The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway.
Martina JA, Lelouvier B, Puertollano R., Free PMC Article | 01/21/2010 |
| These findings reveal a prominent role for TRPML3 in regulating endocytosis, membrane trafficking and autophagy, perhaps by controlling the Ca(2+) in the vicinity of cellular organelles that is necessary to regulate these cellular events. | The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy.
Kim HJ, Soyombo AA, Tjon-Kon-Sang S, So I, Muallem S., Free PMC Article | 01/21/2010 |
| The deaf-waddler isoform of PMCA2, operating at 30% efficacy, showed a significantly decreased ability to rescue the Ca(2+) loading of cells expressing TRPML3(A419P). | Life and death of sensory hair cells expressing constitutively active TRPML3.
Grimm C, Jörs S, Heller S., Free PMC Article | 01/21/2010 |
| First characterization of wild-type TRPML3 calcium-permeable channel properties and its regulation by extracytosolic (luminal)hydrogen ion (H+). | A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype.
Kim HJ, Li Q, Tjon-Kon-Sang S, So I, Kiselyov K, Soyombo AA, Muallem S., Free PMC Article | 01/21/2010 |
| The A419P mutation affects TRPLMe channel glycosylation and causes massive cell death | Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype.
Kim HJ, Li Q, Tjon-Kon-Sang S, So I, Kiselyov K, Muallem S. | 01/21/2010 |
| TRPML3(A419P) and (I362T+A419P) at physiological potentials may have a role in hair cell degeneration and deafness | The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration.
Nagata K, Zheng L, Madathany T, Castiglioni AJ, Bartles JR, García-Añoveros J., Free PMC Article | 01/21/2010 |
| there is a hierarchy controlling the subcellular distributions of the TRPMLs such that TRPML1 and TRPML2 dictate the localization of TRPML3 and not vice versa | Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1.
Venkatachalam K, Hofmann T, Montell C., Free PMC Article | 01/21/2010 |