| Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis. | Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis.
Li J, Zhang B, Feng Z, An D, Zhou Z, Wan C, Hu Y, Sun Y, Wang Y, Liu X, Wei W, Yang X, Meng J, Che M, Sheng Y, Wu B, Wen L, Huang F, Li Y, Yang K. | 02/12/2024 |
| Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation. | Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation.
Diamanti T, Trobiani L, Mautone L, Serafini F, Gioia R, Ferrucci L, Lauro C, Bianchi S, Perfetto C, Guglielmo S, Sollazzo R, Giorda E, Setini A, Ragozzino D, Miranda E, Comoletti D, Di Angelantonio S, Cacci E, De Jaco A. | 02/6/2024 |
| Neuron-secreted NLGN3 ameliorates ischemic brain injury via activating Galphai1/3-Akt signaling. | Neuron-secreted NLGN3 ameliorates ischemic brain injury via activating Gαi1/3-Akt signaling.
Chen ZG, Shi X, Zhang XX, Yang FF, Li KR, Fang Q, Cao C, Chen XH, Peng Y., Free PMC Article | 11/13/2023 |
| Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency. | Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency.
Oleari R, Lettieri A, Manzini S, Paganoni A, André V, Grazioli P, Busnelli M, Duminuco P, Vitobello A, Philippe C, Bizaoui V, Storr HL, Amoruso F, Memi F, Vezzoli V, Massa V, Scheiffele P, Howard SR, Cariboni A., Free PMC Article | 03/30/2023 |
| Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders. | Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders.
Zhang Z, Hou M, Ou H, Wang D, Li Z, Zhang H, Lu J., Free PMC Article | 03/3/2023 |
| Neuronal-driven glioma growth requires Galphai1 and Galphai3. | Neuronal-driven glioma growth requires Gαi1 and Gαi3.
Wang Y, Liu YY, Chen MB, Cheng KW, Qi LN, Zhang ZQ, Peng Y, Li KR, Liu F, Chen G, Cao C., Free PMC Article | 01/29/2022 |
| Evidence for a Contribution of the Nlgn3/Cyfip1/Fmr1 Pathway in the Pathophysiology of Autism Spectrum Disorders. | Evidence for a Contribution of the Nlgn3/Cyfip1/Fmr1 Pathway in the Pathophysiology of Autism Spectrum Disorders.
Sledziowska M, Galloway J, Baudouin SJ. | 06/19/2021 |
| We report gut symptoms in patients with the autism-associated R451C mutation encoding the neuroligin-3 protein. We show that many of the genes implicated in autism are expressed in mouse gut. The neuroligin-3 R451C mutation alters the enteric nervous system, causes gastrointestinal dysfunction, and disrupts gut microbe populations in mice. | Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3.
Hosie S, Ellis M, Swaminathan M, Ramalhosa F, Seger GO, Balasuriya GK, Gillberg C, Råstam M, Churilov L, McKeown SJ, Yalcinkaya N, Urvil P, Savidge T, Bell CA, Bodin O, Wood J, Franks AE, Bornstein JC, Hill-Yardin EL., Free PMC Article | 08/1/2020 |
| Our report of two missense variants affecting the normal localization of NLGN3 in a total of five affected individuals reinforces the involvement of the NLGN3 gene in a neurodevelopmental disorder characterized by ID and ASD. | Novel mutations in NLGN3 causing autism spectrum disorder and cognitive impairment.
Quartier A, Courraud J, Thi Ha T, McGillivray G, Isidor B, Rose K, Drouot N, Savidan MA, Feger C, Jagline H, Chelly J, Shaw M, Laumonnier F, Gecz J, Mandel JL, Piton A. | 03/14/2020 |
| NLGN3 promoted neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway and providing a new target for neuroblastoma therapy | NLGN3 promotes neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway.
Li Z, Gao W, Fei Y, Gao P, Xie Q, Xie J, Xu Z. | 01/18/2020 |
| the effects of rs1421589 within NRXN1, rs4844285 and rs11795613 within NLGN3, as well as rs5961397 within NLGX4X on Hirschsprung's disease phenotypes were also statistically significant. | Significance of neurexin and neuroligin polymorphisms in regulating risk of Hirschsprung's disease.
Li Y, Liu H, Dong Y., Free PMC Article | 10/5/2019 |
| Wnt/beta-catenin signaling targets the trasncription of the autism-associated Neuroligin 3 gene. | Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene.
Medina MA, Andrade VM, Caracci MO, Avila ME, Verdugo DA, Vargas MF, Ugarte GD, Reyes AE, Opazo C, De Ferrari GV., Free PMC Article | 12/22/2018 |
| NLGN3 protects retinal pigment epithelium (RPE) cells and retinal ganglion cells (RGCs) from H2O2. | Neuroligin-3 protects retinal cells from H(2)O(2)-induced cell death via activation of Nrf2 signaling.
Li XM, Huang D, Yu Q, Yang J, Yao J. | 11/10/2018 |
| Our data suggest that these four previously described neuroligin mutations are not primary risk factors for autism. | Not all neuroligin 3 and 4X missense variants lead to significant functional inactivation.
Xu X, Hu Z, Zhang L, Liu H, Cheng Y, Xia K, Zhang X., Free PMC Article | 07/21/2018 |
| high-grade gliomas growth depends on microenvironmental NLGN3, identify signalling cascades downstream of NLGN3 binding in glioma, and determine a therapeutically targetable mechanism of secretion | Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma.
Venkatesh HS, Tam LT, Woo PJ, Lennon J, Nagaraja S, Gillespie SM, Ni J, Duveau DY, Morris PJ, Zhao JJ, Thomas CJ, Monje M., Free PMC Article | 03/3/2018 |
| e found that NLGN3 function at inhibitory synapses in rat CA1 depends on the presence of NLGN2 and identified a domain in the extracellular region that accounted for this functional difference between NLGN2 and 3 specifically at inhibitory synapses. | Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses.
Nguyen QA, Horn ME, Nicoll RA., Free PMC Article | 11/26/2017 |
| No statistically significant haplotypes have been found associated to autism in the NLGN3 after logistic regression and permutation analysis. | Association Analysis of Noncoding Variants in Neuroligins 3 and 4X Genes with Autism Spectrum Disorder in an Italian Cohort.
Landini M, Merelli I, Raggi ME, Galluccio N, Ciceri F, Bonfanti A, Camposeo S, Massagli A, Villa L, Salvi E, Cusi D, Molteni M, Milanesi L, Marabotti A, Mezzelani A., Free PMC Article | 03/25/2017 |
| The synaptic protein neuroligin-3 (NLGN3) was identified as the leading candidate mitogen, and soluble NLGN3 was sufficient and necessary to promote robust high-grade glioma cell proliferation. | Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion.
Venkatesh HS, Johung TB, Caretti V, Noll A, Tang Y, Nagaraja S, Gibson EM, Mount CW, Polepalli J, Mitra SS, Woo PJ, Malenka RC, Vogel H, Bredel M, Mallick P, Monje M., Free PMC Article | 04/30/2016 |
| Our data provided a further evidence for the involvement of NLGN3 and NLGN4X gene in the pathogenesis of autism in Chinese population. | Variations analysis of NLGN3 and NLGN4X gene in Chinese autism patients.
Xu X, Xiong Z, Zhang L, Liu Y, Lu L, Peng Y, Guo H, Zhao J, Xia K, Hu Z. | 02/14/2015 |
| The present study explores, for the first time, the contribution of NLGN3 and NLGN4X genetic variants in Greek patients with autistic disorder. | Mutation screening in the Greek population and evaluation of NLGN3 and NLGN4X genes causal factors for autism.
Volaki K, Pampanos A, Kitsiou-Tzeli S, Vrettou C, Oikonomakis V, Sofocleous C, Kanavakis E. | 05/24/2014 |
| Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population. | Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population.
Liu Y, Du Y, Liu W, Yang C, Liu Y, Wang H, Gong X., Free PMC Article | 08/31/2013 |
| Neuroligins are adhesion proteins that bind to beta-neurexin to form functional synapses. | Analysis of the genes encoding neuroligins NLGN3 and NLGN4 in Bulgarian patients with autism.
Avdjieva-Tzavella DM, Todorov TP, Todorova AP, Kirov AV, Hadjidekova SP, Rukova BB, Litvinenko IO, Hristova-Naydenova DN, Tincheva RS, Toncheva DI. | 04/6/2013 |
| Data from studies using cross-linking reagents suggest that neuroligins form dimers, including homodimers and, most notably, neuroligin 1/3 heteromers; autism-associated neuroligin mutant (neuroligin 3 R471C) forms heterodimers with neuroligin 1. | Homodimerization and isoform-specific heterodimerization of neuroligins.
Poulopoulos A, Soykan T, Tuffy LP, Hammer M, Varoqueaux F, Brose N. | 11/3/2012 |
| study provides initial evidence that a common variant in NLGN3 gene may play a role in the etiology of ASDs among affected males in Chinese Han population. | A sex-specific association of common variants of neuroligin genes (NLGN3 and NLGN4X) with autism spectrum disorders in a Chinese Han cohort.
Yu J, He X, Yao D, Li Z, Li H, Zhao Z., Free PMC Article | 09/24/2011 |
| further characterization of the R451C mutation in NLGN3;role in protein folding | Folding anomalies of neuroligin3 caused by a mutation in the alpha/beta-hydrolase fold domain.
De Jaco A, Dubi N, Comoletti D, Taylor P., Free PMC Article | 10/30/2010 |