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    PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [ Homo sapiens (human) ]

    Gene ID: 5300, updated on 7-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Nuclear Phosphoproteome Reveals Prolyl Isomerase PIN1 as a Modulator of Oncogene-Induced Senescence.

    Nuclear Phosphoproteome Reveals Prolyl Isomerase PIN1 as a Modulator of Oncogene-Induced Senescence.
    Mohallem R, Aryal UK., Free PMC Article

    02/26/2024
    PIN1P1 is activated by CREB1 and promotes gastric cancer progression via interacting with YBX1 and upregulating PIN1.

    PIN1P1 is activated by CREB1 and promotes gastric cancer progression via interacting with YBX1 and upregulating PIN1.
    Wang YW, Zhu WJ, Ma RR, Tian YR, Chen X, Gao P., Free PMC Article

    01/30/2024
    The PIN1-YTHDF1 axis promotes breast tumorigenesis via the m[6]A-dependent stabilization of AURKA mRNA.

    The PIN1-YTHDF1 axis promotes breast tumorigenesis via the m(6)A-dependent stabilization of AURKA mRNA.
    Shrestha P, Kim G, Kang H, Bhattarai PY, Choi HS.

    01/16/2024
    Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.

    Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.
    Zhu Q, Liang P, Meng H, Li F, Miao W, Chu C, Wang W, Li D, Chen C, Shi Y, Yu X, Ping Y, Niu C, Wu HB, Zhang A, Bian XW, Zhou W., Free PMC Article

    01/5/2024
    Prolyl isomerase Pin1 promotes autophagy and cancer cell viability through activating FoxO3 signalling.

    Prolyl isomerase Pin1 promotes autophagy and cancer cell viability through activating FoxO3 signalling.
    Long J, Wang J, Dong Y, Yang J, Xie G, Tong Y.

    12/20/2023
    Oxygen-independent stabilization of HIF-2alpha in breast cancer through direct interaction with peptidyl-prolyl cis-trans isomerase NIMA-interacting 1.

    Oxygen-independent stabilization of HIF-2α in breast cancer through direct interaction with peptidyl-prolyl cis-trans isomerase NIMA-interacting 1.
    Guillen-Quispe YN, Kim SJ, Saeidi S, Zhou T, Zheng J, Kim SH, Fang X, Chelakkot C, Rios-Castillo ME, Shin YK, Surh YJ.

    10/4/2023
    The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C theta; via a critical Phospho-Thr-Pro motif in the V3 regulatory domain.

    The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C θ via a critical Phospho-Thr-Pro motif in the V3 regulatory domain.
    Anto NP, Muraleedharan A, Nath PR, Sun Z, Keasar C, Livneh E, Braiman A, Altman A, Kong KF, Isakov N., Free PMC Article

    03/31/2023
    Prolyl isomerase Pin1 promotes extracellular matrix production in hepatic stellate cells through regulating formation of the Smad3-TAZ complex.

    Prolyl isomerase Pin1 promotes extracellular matrix production in hepatic stellate cells through regulating formation of the Smad3-TAZ complex.
    Aoyama S, Kido Y, Kanamoto M, Naito M, Nakanishi M, Kanna M, Yamamotoya T, Asano T, Nakatsu Y.

    03/31/2023
    METTL3 stabilization by PIN1 promotes breast tumorigenesis via enhanced m[6]A-dependent translation.

    METTL3 stabilization by PIN1 promotes breast tumorigenesis via enhanced m(6)A-dependent translation.
    Bhattarai PY, Kim G, Lim SC, Mariappan R, Ohn T, Choi HS.

    03/29/2023
    Key role of PIN1 in telomere maintenance and oncogenic behavior in a human glioblastoma model.

    Key role of PIN1 in telomere maintenance and oncogenic behavior in a human glioblastoma model.
    Maggio J, Cardama GA, Armando RG, Balcone L, Sobol NT, Gomez DE, Mengual Gómez DL.

    03/27/2023
    Pin1 and Alzheimer's disease.

    Pin1 and Alzheimer's disease.
    Malter JS., Free PMC Article

    03/14/2023
    Mechanical Regulation of Redox Balance via the Induction of the PIN1/NRF2/ARE Axis in Pancreatic Cancer.

    Mechanical Regulation of Redox Balance via the Induction of the PIN1/NRF2/ARE Axis in Pancreatic Cancer.
    Liang C, Rong Z, Tuerhong A, Meng Q, Hua J, Liu J, Zhang B, Wang W, Yu X, Shi S, Xu J., Free PMC Article

    03/2/2023
    Spastin Promotes the Migration and Invasion Capability of T98G Glioblastoma Cells by Interacting with Pin1 through Its Microtubule-Binding Domain.

    Spastin Promotes the Migration and Invasion Capability of T98G Glioblastoma Cells by Interacting with Pin1 through Its Microtubule-Binding Domain.
    Temizci B, Kucukvardar S, Karabay A., Free PMC Article

    02/15/2023
    Targeting prolyl isomerase Pin1 as a promising strategy to overcome resistance to cancer therapies.

    Targeting prolyl isomerase Pin1 as a promising strategy to overcome resistance to cancer therapies.
    Wu W, Xue X, Chen Y, Zheng N, Wang J.

    10/22/2022
    Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension.

    Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension.
    Rai N, Sydykov A, Kojonazarov B, Wilhelm J, Manaud G, Veeroju S, Ruppert C, Perros F, Ghofrani HA, Weissmann N, Seeger W, Schermuly RT, Novoyatleva T., Free PMC Article

    09/3/2022
    Circulating levels of PIN1 and glucose metabolism in young people with obesity.

    Circulating levels of PIN1 and glucose metabolism in young people with obesity.
    Bianchi M, Manco M.

    08/20/2022
    Impact of PIN1 Inhibition on Tumor Progression and Chemotherapy Sensitivity in Colorectal Cancer.

    Impact of PIN1 Inhibition on Tumor Progression and Chemotherapy Sensitivity in Colorectal Cancer.
    Gholamzadeh Khoei S, Saidijam M, Amini R, Jalali A, Najafi R.

    06/18/2022
    Association of polymorphisms in PIN1 with progression and susceptibility in gastric cancer.

    Association of polymorphisms in PIN1 with progression and susceptibility in gastric cancer.
    Huang L, Luo R, Yang Z, Xu J, Li H, Mo Z.

    04/16/2022
    Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 directly binds and stabilizes Nrf2 in breast cancer.

    Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 directly binds and stabilizes Nrf2 in breast cancer.
    Saeidi S, Kim SJ, Guillen-Quispe YN, Jagadeesh ASV, Han HJ, Kim SH, Zhong X, Piao JY, Kim SJ, Jeong J, Shin YJ, Cha YJ, Lee HB, Han W, Min SH, Tian W, Kitamura H, Surh YJ.

    01/15/2022
    PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway.

    PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway.
    Zhang Y, Lv Z, Liu Y, Cao H, Yang J, Wang B., Free PMC Article

    01/1/2022
    Pin1 and JNK1 cooperatively modulate TAp63gamma.

    Pin1 and JNK1 cooperatively modulate TAp63γ.
    Fan X, He W, Hu K, Chen H, Chen L, Fan S, Li C., Free PMC Article

    01/1/2022
    Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development.

    Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development.
    Viswakarma N, Sondarva G, Principe DR, Nair RS, Kumar S, Singh SK, Das S, Sinha SC, Grippo PJ, Grimaldo S, Giulianotti PC, Rana B, Rana A., Free PMC Article

    12/25/2021
    Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions.

    Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions.
    Kumari A, Kumar C, Pergu R, Kumar M, Mahale SP, Wasnik N, Mylavarapu SVS., Free PMC Article

    12/25/2021
    Screening of the HBx transactivation domain interacting proteins and the function of interactor Pin1 in HBV replication.

    Screening of the HBx transactivation domain interacting proteins and the function of interactor Pin1 in HBV replication.
    Zhou Q, Yan L, Xu B, Wang X, Sun X, Han N, Tang H, Huang F., Free PMC Article

    11/6/2021
    Cysteine-113 covalency inspires the development of Pin1 inhibitor.

    Cysteine-113 covalency inspires the development of Pin1 inhibitor.
    Pu W, Li J, Peng Y., Free PMC Article

    10/16/2021
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