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    UIMC1 ubiquitin interaction motif containing 1 [ Homo sapiens (human) ]

    Gene ID: 51720, updated on 11-Apr-2024

    GeneRIFs: Gene References Into Functions

    Submit: New GeneRIFCorrection

    GeneRIFPubMed TitleDate
    RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair.

    RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair.
    Yasuhara T, Kato R, Yamauchi M, Uchihara Y, Zou L, Miyagawa K, Shibata A.

    		02/26/2022
    BRCA1 poly-ADP ribosylation (PARsylation) and the presence of BRCA1-bound RAP80 are critical for the normal interaction of BRCA1 with some of its partners (e.g., CtIP and BACH1).

    RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci.
    Vohhodina J, Toomire KJ, Petit SA, Micevic G, Kumari G, Botchkarev VV Jr, Li Z, Livingston DM, Hu Y., Free PMC Article

    		06/6/2020
    Here we show that in the BRCA1-A complex structure, ABRAXAS integrates the DNA repair protein RAP80 and provides a high-affinity binding site that sequesters the tumor suppressor BRCA1 away from the break site. In the BRISC structure, ABRO1 binds SHMT2alpha, a metabolic enzyme enabling cancer growth in hypoxic environments, which we find prevents BRCC36 from binding and cleaving ubiquitin chains

    Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
    Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, Andrés-Pons A, Luijsterburg MS, Ibrahim AFM, Branigan E, Aguirre JD, Marceau AH, Guérillon C, Bouwmeester T, Hassiepen U, Peters AHFM, Renatus M, Gelman L, Rubin SM, Mailand N, van Attikum H, Hay RT, Thomä NH., Free PMC Article

    		01/18/2020
    RAP80 positively regulated the stability of USP13 to promote cell proliferation of esophageal cancer cells.

    RAP80 is an independent prognosis biomarker for the outcome of patients with esophageal squamous cell carcinoma.
    Yang Q, Lin W, Liu Z, Zhu J, Huang N, Cui Z, Han Z, Pan Q, Goel A, Sun F., Free PMC Article

    		08/3/2019
    RAP80-BRCA1 complex foci formation is regulated by USP13.USP13 interacts with and deubiquitinates RAP80.RAP80 role in the DNA damage response.

    USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response.
    Li Y, Luo K, Yin Y, Wu C, Deng M, Li L, Chen Y, Nowsheen S, Lou Z, Yuan J., Free PMC Article

    		12/22/2018
    The RAP80 deficiency reduces the protein level of p32 and p32 dependent mitochondrial translating proteins such as Rieske and COX1.

    RAP80 binds p32 to preserve the functional integrity of mitochondria.
    Chung HJ, Korm S, Lee SI, Phorl S, Noh S, Han M, Naskar R, Kim H, Lee JY.

    		10/28/2017
    Low RAP80 mRNA expression correlates with sporadic high-grade serous ovarian carcinoma.

    Low RAP80 mRNA expression correlates with shorter survival in sporadic high-grade serous ovarian carcinoma.
    Romeo M, Karachaliou N, Chaid I, Queralt C, De Aguirre I, Del Carmen Gómez M, Sanchez-Ronco M, Radua J, Ramírez JL, Rosell R.

    		04/8/2017
    RAP80 is a critical gatekeeper in impeding epithelial-mesenchymal transition-induced metastasis and malignant phenotypes of cancer as well as preserving DNA integrity.

    RAP80 regulates epithelial-mesenchymal transition related with metastasis and malignancy of cancer.
    Park SY, Korm S, Chung HJ, Choi SJ, Jang JJ, Cho S, Lim YT, Kim H, Lee JY., Free PMC Article

    		08/13/2016
    Data suggest that RAP80 SIM (SUMO interacting motif) binds SUMO-2; both specificity and affinity are enhanced through phosphorylation of canonical CK2 (casein kinase 2) site within the SIM.

    Molecular Basis for Phosphorylation-dependent SUMO Recognition by the DNA Repair Protein RAP80.
    Anamika, Spyracopoulos L., Free PMC Article

    		08/6/2016
    Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells.

    Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells.
    Renaud E, Barascu A, Rosselli F., Free PMC Article

    		06/28/2016
    TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage.(

    TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage.
    Soo Lee N, Jin Chung H, Kim HJ, Yun Lee S, Ji JH, Seo Y, Hun Han S, Choi M, Yun M, Lee SG, Myung K, Kim Y, Chul Kang H, Kim H., Free PMC Article

    		05/28/2016
    A new role of FANCG in Homologous recombination repair of interstrand crosslinks through K63Ub-mediated interaction with the Rap80-BRCA1 complex.

    K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks.
    Zhu B, Yan K, Li L, Lin M, Zhang S, He Q, Zheng D, Yang H, Shao G.

    		08/29/2015
    patients with low RAP80 expression received gemcitabine/cisplatin, those with intermediate/high RAP80 expression and low/intermediate BRCA1 expression received docetaxel/cisplatin

    Two biomarker-directed randomized trials in European and Chinese patients with nonsmall-cell lung cancer: the BRCA1-RAP80 Expression Customization (BREC) studies.
    Moran T, Wei J, Cobo M, Qian X, Domine M, Zou Z, Bover I, Wang L, Provencio M, Yu L, Chaib I, You C, Massuti B, Song Y, Vergnenegre A, Lu H, Lopez-Vivanco G, Hu W, Robinet G, Yan J, Insa A, Xu X, Majem M, Chen X, de Las Peñas R, Karachaliou N, Sala MA, Wu Q, Isla D, Zhou Y, Baize N, Zhang F, Garde J, Germonpre P, Rauh S, ALHusaini H, Sanchez-Ronco M, Drozdowskyj A, Sanchez JJ, Camps C, Liu B, Rosell R, Spanish Lung Cancer Group, the French Lung Cancer Group and the Comprehensive Cancer Centre of Drum Tower Hospital in Nanjing, Colinet B, De Grève J, Germonpré P, Chen H, Chen X, Du J, Gao Y, Hu J, Hu W, Kong W, Li L, Li R, Li X, Liu B, Liu J, Lu H, Qian X, Ren W, Song Y, Wang L, Wei J, Wen L, Wu Q, Xiao X, Xu X, Yan J, Yang J, Yang M, Yang Y, Yin J, You C, Yu L, Yue X, Zhang F, Zhang J, Zhou Y, Zhu L, Zou Z, Baize N, Bombaron P, Chouaid C, Dansin E, Fournel P, Fraboulet G, Gervais R, Hominal S, Kahlout S, Lecaer H, Lena H, LeTreut J, Locher C, Molinier O, Monnet I, Oliviero G, Robinet G, Schoot R, Thomas P, Vergnènegre A, Berchem G, Rauh S, Al Husaini H, Aparisi F, Arriola E, Ballesteros I, Barneto I, Bernabé R, Blasco A, Bosch-Barrera J, Bover I, Calvo de Juan V, Camps C, Carcereny E, Catot S, Cobo M, De Las Peñas R, Dómine M, Felip E, García-Campelo MR, García-Girón C, García-Gómez R, Garcia-Sevila R, Garde J, Gasco A, Gil J, González-Larriba JL, Hernando-Polo S, Jantus E, Insa A, Isla D, Jiménez B, Lianes P, López-López R, López-Martín A, López-Vivanco G, Macias JA, Majem M, Marti-Ciriquian JL, Massuti B, Montoyo R, Morales-Espinosa D, Morán T, Moreno MA, Pallares C, Parera M, Pérez-Carrión R, Porta R, Provencio M, Reguart N, Rosell R, Rosillo F, Sala MA, Sanchez JM, Sullivan I, Terrasa J, Trigo JM, Valdivia J, Viñolas N, Viteri S, Botia-Castillo M, Mate JL, Perez-Cano M, Ramirez JL, Sanchez-Rodriguez B, Taron M, Tierno-Garcia M, Mijangos E, Ocaña J, Pereira E, Shao J, Sun X, O'Brate R.

    		07/4/2015
    Data indicate that a single point deletion (DeltaE81) in RAP80 abrogates multivalent interactions with polyubiquitin.

    Molecular basis for impaired DNA damage response function associated with the RAP80 ΔE81 defect.
    Anamika, Markin CJ, Rout MK, Spyracopoulos L., Free PMC Article

    		08/9/2014
    connect ubiquitin- and SUMO-dependent DSB recognition, revealing that RNF4-synthesized hybrid SUMO-ubiquitin chains are recognized by RAP80 to promote BRCA1 recruitment and DNA repair.

    RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.
    Guzzo CM, Berndsen CE, Zhu J, Gupta V, Datta A, Greenberg RA, Wolberger C, Matunis MJ., Free PMC Article

    		05/25/2013
    post-translational phosphorylation of RAP80 by the Cdk1-cyclin B(1) complex is important for RAP80 functional sensitivity to IR and G(2)/M checkpoint control.

    Cdk1 protein-mediated phosphorylation of receptor-associated protein 80 (RAP80) serine 677 modulates DNA damage-induced G2/M checkpoint and cell survival.
    Cho HJ, Oh YJ, Han SH, Chung HJ, Kim CH, Lee NS, Kim WJ, Choi JM, Kim H., Free PMC Article

    		04/20/2013
    Loss of RAP80 abolishes the recruitment of the BRCA1-A complex to DNA lesions in response to DNA damage.

    Loss of BRCA1-A complex function in RAP80 null tumor cells.
    Bian C, Wu R, Cho K, Yu X., Free PMC Article

    		04/6/2013
    APC/C(Cdc20) or APC/C(Cdh1) complexes regulate RAP80 stability during mitosis to the G(1) phase, and these events are critical for a novel function of RAP80 in mitotic progression.

    Degradation of human RAP80 is cell cycle regulated by Cdc20 and Cdh1 ubiquitin ligases.
    Cho HJ, Lee EH, Han SH, Chung HJ, Jeong JH, Kwon J, Kim H.

    		11/24/2012
    We show that RNF168, its paralog RNF169, RAD18, and the BRCA1-interacting RAP80 protein accumulate at DNA double strand break sites through the use of bipartite modules composed of ubiquitin binding domains.

    Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.
    Panier S, Ichijima Y, Fradet-Turcotte A, Leung CC, Kaustov L, Arrowsmith CH, Durocher D.

    		10/27/2012
    a model in which SUMO and Ub modification is coordinated to recruit Rap80 and BRCA1 to DNA damage sites.

    Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates.
    Hu X, Paul A, Wang B., Free PMC Article

    		10/20/2012
    MDC1 is required for the recruitment of RAP80 to DNA double-strand breaks.

    Recruitment of proteins to DNA double-strand breaks: MDC1 directly recruits RAP80.
    Strauss C, Goldberg M.

    		03/24/2012
    The interaction between MDC1 and RAP80 requires the tandem BRCT domain of MDC1 and the ubiquitin-interacting motifs of RAP80

    MDC1 is ubiquitylated on its tandem BRCT domain and directly binds RAP80 in a UBC13-dependent manner.
    Strauss C, Halevy T, Macarov M, Argaman L, Goldberg M.

    		12/31/2011
    a model in which the BRCA1-RAP80 complex limits nuclease accessibility to DSBs, thus preventing excessive end resection and potentially deleterious homology-directed DSB repair mechanisms that can impair genome integrity.

    The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection.
    Coleman KA, Greenberg RA., Free PMC Article

    		07/2/2011
    RAP80/BRCA1 complexes suppress excessive double-strand break end processing, HR-type double-strand break repair, and overt chromosomal instability

    RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci.
    Hu Y, Scully R, Sobhian B, Xie A, Shestakova E, Livingston DM., Free PMC Article

    		05/21/2011
    Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

    Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
    He C, Kraft P, Chen C, Buring JE, Paré G, Hankinson SE, Chanock SJ, Ridker PM, Hunter DJ, Chasman DI., Free PMC Article

    		12/2/2009
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