| Neurofibromin 1 mediates sleep depth in Drosophila. | Neurofibromin 1 mediates sleep depth in Drosophila.
Brown EB, Zhang J, Lloyd E, Lanzon E, Botero V, Tomchik S, Keene AC., Free PMC Article | 01/26/2024 |
| Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling. | Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling.
Machado Almeida P, Lago Solis B, Stickley L, Feidler A, Nagoshi E., Free PMC Article | 10/23/2021 |
| Social Behavioral Deficits with Loss of Neurofibromin Emerge from Peripheral Chemosensory Neuron Dysfunction. | Social Behavioral Deficits with Loss of Neurofibromin Emerge from Peripheral Chemosensory Neuron Dysfunction.
Moscato EH, Dubowy C, Walker JA, Kayser MS., Free PMC Article | 05/1/2021 |
| Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila. | Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila.
King LB, Boto T, Botero V, Aviles AM, Jomsky BM, Joseph C, Walker JA, Tomchik SM., Free PMC Article | 09/12/2020 |
| Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster. | Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster.
Lee SF, Eyre-Walker YC, Rane RV, Reuter C, Vinti G, Rako L, Partridge L, Hoffmann AA., Free PMC Article | 11/2/2013 |
| The N-terminal region of NF1 mediates the interaction with Fak56 and is required for the signaling activity and presynaptic localization of NF1 | Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions.
Tsai PI, Wang M, Kao HH, Cheng YJ, Walker JA, Chen RH, Chien CT., Free PMC Article | 02/2/2013 |
| These results identify dAlk as an upstream activator of dNf1-regulated Ras signaling responsible for several dNf1 defects, and they implicate human Alk as a potential therapeutic target in NF1 | The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning.
Gouzi JY, Moressis A, Walker JA, Apostolopoulou AA, Palmer RH, Bernards A, Skoulakis EM., Free PMC Article | 01/28/2012 |
| memory-related functions of Rut-AC are both Nf1-dependent and -independent, that Nf1 mediates the formation of two distinct memory components within a single neuron population. | A distinct set of Drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory.
Buchanan ME, Davis RL., Free PMC Article | 08/23/2010 |
| survival of a subset of midline glia cells depends upon direct suppression of the proapoptotic protein HID via the EGF receptor/RAS/MAPK pathway | Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling.
Bergmann A, Tugentman M, Shilo BZ, Steller H. | 01/21/2010 |
| Data show that rolled nuclear translocation is regulated by a second mechanism in addition to phosphorylation, and may be held in the cytoplasm for hours. | Nuclear translocation of activated MAP kinase is developmentally regulated in the developing Drosophila eye.
Kumar JP, Hsiung F, Powers MA, Moses K., Free PMC Article | 01/21/2010 |
| role in insulin-mediated proliferation of Schneider cells | Drosophila extracellular signal-regulated kinase involves the insulin-mediated proliferation of Schneider cells.
Kwon HB, Kim SH, Kim SE, Jang IH, Ahn Y, Lee WJ, Choi KY. | 01/21/2010 |
| Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras | Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras.
Hannan F, Ho I, Tong JJ, Zhu Y, Nurnberg P, Zhong Y., Free PMC Article | 01/21/2010 |
| preliminary crystallographic characterization of a novel segment (homologous to the yeast Sec14p lipid exchange protein) from the neurofibromatosis type 1 protein | Expression, purification and preliminary crystallographic characterization of a novel segment from the neurofibromatosis type 1 protein.
Bonneau F, D'Angelo I, Welti S, Stier G, Ylänne J, Scheffzek K. | 01/21/2010 |
| Neurofibromin regulates longevity and stress resistance through cAMP regulation of mitochondrial respiration and ROS production, and NF1 may be treatable using catalytic antioxidants. | Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster.
Tong JJ, Schriner SE, McCleary D, Day BJ, Wallace DC. | 01/21/2010 |
| Loss of NF1 can give rise to non-cell-autonomous developmental defects, implicate aberrant Ras-mediated signaling in larval neurons as the primary cause of the NF1 growth deficiency. | Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.
Walker JA, Tchoudakova AV, McKenney PT, Brill S, Wu D, Cowley GS, Hariharan IK, Bernards A., Free PMC Article | 01/21/2010 |
| role for nf1 in circadian output via the Ras/MAPK signaling pathway | A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK.
Williams JA, Su HS, Bernards A, Field J, Sehgal A, Williams JA, Su HS, Bernards A, Field J, Sehgal A. | 07/21/2005 |
| role in circadian output via the Ras/MAPK signaling pathway | A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK.
Williams JA, Su HS, Bernards A, Field J, Sehgal A, Williams JA, Su HS, Bernards A, Field J, Sehgal A. | 09/29/2001 |