| we elucidate a mechanism through which the DBL family members MCF2 and VAV1 act to drive drug resistance in human BRAFV600E-mutant melanoma cells | Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma.
Feddersen CR, Schillo JL, Varzavand A, Vaughn HR, Wadsworth LS, Voigt AP, Zhu EY, Jennings BM, Mullen SA, Bobera J, Riordan JD, Stipp CS, Dupuy AJ., Free PMC Article | 05/30/2020 |
| Results support a role for Dbl oncogene in mammary epithelial cell differentiation and transformation and suggest the relevance of GEF deregulation in tumor onset and progression. | Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion.
Vanni C, Ognibene M, Finetti F, Mancini P, Cabodi S, Segalerba D, Torrisi MR, Donnini S, Bosco MC, Varesio L, Eva A., Free PMC Article | 02/27/2016 |
| Phosphoinositide 3-kinase C2beta regulates RhoA and the actin cytoskeleton through an interaction with Dbl | Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl.
Błajecka K, Marinov M, Leitner L, Uth K, Posern G, Arcaro A., Free PMC Article | 03/16/2013 |
| Dbl is regulated by hamartin through association with ezrin. | The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrin.
Ognibene M, Vanni C, Segalerba D, Mancini P, Merello E, Torrisi MR, Bosco MC, Varesio L, Eva A., Free PMC Article | 10/22/2011 |
| proto-oncogene dbl is not a major target for sporadic testicular germ cell tumors | Mutational analysis of proto-oncogene Dbl on Xq27 in testicular germ cell tumors reveals a rare SNP in a patient with bilateral undescended testis.
Xu WH, Zhang C, Zhao WM, Li CM, Xiu YC, Ni SB, Ren MH, Sun DJ. | 07/2/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.
Piton A, Gauthier J, Hamdan FF, Lafrenière RG, Yang Y, Henrion E, Laurent S, Noreau A, Thibodeau P, Karemera L, Spiegelman D, Kuku F, Duguay J, Destroismaisons L, Jolivet P, Côté M, Lachapelle K, Diallo O, Raymond A, Marineau C, Champagne N, Xiong L, Gaspar C, Rivière JB, Tarabeux J, Cossette P, Krebs MO, Rapoport JL, Addington A, Delisi LE, Mottron L, Joober R, Fombonne E, Drapeau P, Rouleau GA., Free PMC Article | 06/30/2010 |
| Nm23-H1 can negatively regulate cell migration and tumor metastasis by modulating the activity of Cdc42 and possibly other Rho family members through interaction with Dbl-1 | The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration.
Murakami M, Meneses PI, Lan K, Robertson ES. | 01/21/2010 |
| Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain | Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain.
Rojas RJ, Yohe ME, Gershburg S, Kawano T, Kozasa T, Sondek J., Free PMC Article | 01/21/2010 |
| These data suggest a mechanism whereby precise spatial guanine nucleotide exchange of Cdc42 by Dbl is dependent on functional ERM proteins and is important for directional cell migration. | Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.
Prag S, Parsons M, Keppler MD, Ameer-Beg SM, Barber P, Hunt J, Beavil AJ, Calvert R, Arpin M, Vojnovic B, Ng T., Free PMC Article | 01/21/2010 |
| data describe 4 splicing variants of the human DBL (MCF-2) proto-oncogene that show different tissue distributions and guanine nucleotide exchange factor specificities | Alternative splicing variants of the human DBL (MCF-2) proto-oncogene.
Komai K, Okayama R, Kitagawa M, Yagi H, Chihara K, Shiozawa S. | 01/21/2010 |
| provides fundamental data on the structure of Mcf-2, which regulates a variety of cellular signaling pathways | Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene.
Komai K, Mukae-Sakairi N, Kitagawa M, Shiozawa S. | 01/21/2010 |