| Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer. | Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer.
Yang W, Chen H, Li G, Zhang T, Sui Y, Liu L, Hu J, Wang G, Chen H, Wang Y, Li X, Tan H, Kong R, Sun B, Li L., Free PMC Article | 12/20/2023 |
| CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma. | CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma.
Kurhade C, Kang S, Biering SB, Hwang S, Randall G., Free PMC Article | 06/29/2023 |
| Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH. | Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH.
Schulte T, Panas MD, Han X, Williams L, Kedersha N, Fleck JS, Tan TJC, Dopico XC, Olsson A, Morro AM, Hanke L, Nilvebrant J, Giang KA, Nygren PÅ, Anderson P, Achour A, McInerney GM., Free PMC Article | 05/11/2023 |
| Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP. | Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP.
Gao Y, Yuan L, Ke C, Pei Z, Liu X, Wu R, Kui X, Zhang Y., Free PMC Article | 03/2/2023 |
| CAPRIN1 haploinsufficiency causes a neurodevelopmental disorder with language impairment, ADHD and ASD. | CAPRIN1 haploinsufficiency causes a neurodevelopmental disorder with language impairment, ADHD and ASD.
Pavinato L, Delle Vedove A, Carli D, Ferrero M, Carestiato S, Howe JL, Agolini E, Coviello DA, van de Laar I, Au PYB, Di Gregorio E, Fabbiani A, Croci S, Mencarelli MA, Bruno LP, Renieri A, Veltra D, Sofocleous C, Faivre L, Mazel B, Safraou H, Denommé-Pichon AS, van Slegtenhorst MA, Giesbertz N, van Jaarsveld RH, Childers A, Rogers RC, Novelli A, De Rubeis S, Buxbaum JD, Scherer SW, Ferrero GB, Wirth B, Brusco A., Free PMC Article | 02/16/2023 |
| circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer. | circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer.
Yang Y, Luo D, Shao Y, Shan Z, Liu Q, Weng J, He W, Zhang R, Li Q, Wang Z, Li X., Free PMC Article | 01/28/2023 |
| STRESS granule-associated RNA-binding protein CAPRIN1 drives cancer progression and regulates treatment response in nasopharyngeal carcinoma. | STRESS granule-associated RNA-binding protein CAPRIN1 drives cancer progression and regulates treatment response in nasopharyngeal carcinoma.
Yang T, Huang L, Qin H, Mai S., Free PMC Article | 12/24/2022 |
| Long noncoding RNA ZNFX1-AS1 promotes the invasion and proliferation of gastric cancer cells by regulating LIN28 and CAPR1N1. | Long noncoding RNA ZNFX1-AS1 promotes the invasion and proliferation of gastric cancer cells by regulating LIN28 and CAPR1N1.
Zhuo ZL, Xian HP, Sun YJ, Long Y, Liu C, Liang B, Zhao XT., Free PMC Article | 10/1/2022 |
| Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase. | Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase.
Kim TH, Payliss BJ, Nosella ML, Lee ITW, Toyama Y, Forman-Kay JD, Kay LE., Free PMC Article | 12/4/2021 |
| LncRNA SNHG8 induces ovarian carcinoma cells cellular process and stemness through Wnt/beta-catenin pathway. | LncRNA SNHG8 induces ovarian carcinoma cells cellular process and stemness through Wnt/β-catenin pathway.
Miao W, Lu T, Liu X, Yin W, Zhang H. | 04/17/2021 |
| NMR Experiments for Studies of Dilute and Condensed Protein Phases: Application to the Phase-Separating Protein CAPRIN1. | NMR Experiments for Studies of Dilute and Condensed Protein Phases: Application to the Phase-Separating Protein CAPRIN1.
Wong LE, Kim TH, Muhandiram DR, Forman-Kay JD, Kay LE. | 01/30/2021 |
| we knocked down three regulators respectively and found two of them (TRA2A and CAPRIN1) selectively promoted the methylations of the m6A sites co-localized with their binding targets on RNAs through physical interactions with the m6A writers. Knockdown of TRA2A increased the stabilities of the RNAs with TRA2A bound near the m6A sites and decreased the viability of cells | Integrative network analysis identifies cell-specific trans regulators of m6A.
An S, Huang W, Huang X, Cun Y, Cheng W, Sun X, Ren Z, Chen Y, Chen W, Wang J., Free PMC Article | 04/4/2020 |
| this study found that different FMRP serine/threonine and CAPRIN1 tyrosine phosphorylation patterns control phase separation propensity with RNA, including subcompartmentalization, and tune deadenylation and translation rates in vitro. | Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.
Kim TH, Tsang B, Vernon RM, Sonenberg N, Kay LE, Forman-Kay JD. | 02/15/2020 |
| that high Caprin1 expression was significantly associated with worse overall survival for patients with hepatocellular carcinoma | Upregulation of caprin1 expression is associated with poor prognosis in hepatocellular carcinoma.
Tan N, Dai L, Liu X, Pan G, Chen H, Huang J, Xu Q. | 08/11/2018 |
| Based on insights from the structures and existing biochemical data, the existence of an evolutionarily conserved ribonucleoprotein (RNP) complex consisting of Caprin-1, FMRP and G3BP1 is proposed. | Crystal structure of a dimerization domain of human Caprin-1: insights into the assembly of an evolutionarily conserved ribonucleoprotein complex consisting of Caprin-1, FMRP and G3BP1.
Wu Y, Zhu J, Huang X, Du Z., Free PMC Article | 10/28/2017 |
| Data suggest that DEAD-box helicase 3 (DDX3X) physically interacts and co-localizes with poly(A)-binding cytoplasmic protein 1 (PABPC1) and caprin-1 in lamellipodia at the leading edge of spreading cells; these interactions are dependent on mRNA; depletion of DDX3X (via gene silencing with the CRISPR-Cas system) leads to decreased cell motility. These studies were conducted using MRC5 lung fibroblast cell line. | The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.
Copsey AC, Cooper S, Parker R, Lineham E, Lapworth C, Jallad D, Sweet S, Morley SJ., Free PMC Article | 09/16/2017 |
| G3BP mediates the condensation of stress granules by shifting between two different states that are controlled by the phosphorylation of S149 and by binding to Caprin1 or USP10. | G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.
Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P., Free PMC Article | 08/20/2016 |
| The G3BP1-Caprin1-PKR complex represents a new mode of PKR activation and is important for antiviral activity of G3BP1 and PKR during infection with mengovirus. | Stress granules regulate double-stranded RNA-dependent protein kinase activation through a complex containing G3BP1 and Caprin1.
Reineke LC, Kedersha N, Langereis MA, van Kuppeveld FJ, Lloyd RE., Free PMC Article | 02/27/2016 |
| Data show that tylophorine compounds exert anti-cancer activity predominantly by targeting and sequestering the caprin-1 protein and c-Myc mRNA associated ribonucleoprotein complex. | Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget.
Qiu YQ, Yang CW, Lee YZ, Yang RB, Lee CH, Hsu HY, Chang CC, Lee SJ., Free PMC Article | 12/5/2015 |
| G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA. | G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.
Bidet K, Dadlani D, Garcia-Blanco MA., Free PMC Article | 11/7/2015 |
| Cyr61/Caprin-1 co-expression was associated with worse survival. | Caprin-1, a novel Cyr61-interacting protein, promotes osteosarcoma tumor growth and lung metastasis in mice.
Sabile AA, Arlt MJ, Muff R, Husmann K, Hess D, Bertz J, Langsam B, Aemisegger C, Ziegler U, Born W, Fuchs B. | 09/21/2013 |
| These results suggest that the Japanese encephalitis virus core protein circumvents translational shutoff by inhibiting stress granule formation through an interaction with Caprin-1 and facilitates viral propagation in vitro and in vivo. | Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation.
Katoh H, Okamoto T, Fukuhara T, Kambara H, Morita E, Mori Y, Kamitani W, Matsuura Y., Free PMC Article | 03/2/2013 |
| Fragile mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes | Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected].
El Fatimy R, Tremblay S, Dury AY, Solomon S, De Koninck P, Schrader JW, Khandjian EW., Free PMC Article | 12/22/2012 |
| MiR-16 negatively regulate HMGA1 and caprin-1 which are involved in cell proliferation. | Two new miR-16 targets: caprin-1 and HMGA1, proteins implicated in cell proliferation.
Kaddar T, Rouault JP, Chien WW, Chebel A, Gadoux M, Salles G, Ffrench M, Magaud JP. | 01/21/2010 |
| Suppression of expression of human Caprin-1 results in slowing of the proliferation rate, due to prolongation of the G1 phase of the cell cycle, formally demonstrating that Caprin-1 is essential for normal cellular proliferation. | Absence of caprin-1 results in defects in cellular proliferation.
Wang B, David MD, Schrader JW. | 01/21/2010 |