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    KIT KIT proto-oncogene, receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 3815, updated on 13-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Elevated c-kit expression in failed autologous arteriovenous fistulas in end-stage renal disease patients.

    Elevated c-kit expression in failed autologous arteriovenous fistulas in end-stage renal disease patients.
    Du J, Li Y, Jia X, Kong X, Liang L, Wang D, Li A, Chen Q, Su H, Li W, Xu D.

    03/14/2024
    Molecular and clinicopathological features of KIT/PDGFRA wild-type gastrointestinal stromal tumors.

    Molecular and clinicopathological features of KIT/PDGFRA wild-type gastrointestinal stromal tumors.
    Nishida T, Naito Y, Takahashi T, Saito T, Hisamori S, Manaka D, Ogawa K, Hirota S, Ichikawa H., Free PMC Article

    03/13/2024
    CREB Is Indispensable to KIT Function in Human Skin Mast Cells-A Positive Feedback Loop between CREB and KIT Orchestrates Skin Mast Cell Fate.

    CREB Is Indispensable to KIT Function in Human Skin Mast Cells-A Positive Feedback Loop between CREB and KIT Orchestrates Skin Mast Cell Fate.
    Bal G, Schneikert J, Li Z, Franke K, Tripathi SR, Zuberbier T, Babina M., Free PMC Article

    01/16/2024
    Novel somatic Missense Mutations in Exon 11 of the KIT Gene are Detected in Melanoma.

    Novel somatic Missense Mutations in Exon 11 of the KIT Gene are Detected in Melanoma.
    Palkina N, Tyumentseva A, Ruksha T., Free PMC Article

    01/8/2024
    KIT genetic alterations in breast cancer.

    KIT genetic alterations in breast cancer.
    Vahdatinia M, Derakhshan F, Da Cruz Paula A, Dopeso H, Marra A, Gazzo AM, Brown D, Selenica P, Ross DS, Razavi P, Zhang H, Weigelt B, Wen HY, Brogi E, Reis-Filho JS, Pareja F.,

    12/18/2023
    KIT Mutations and Other Genetic Defects in Mastocytosis: Implications for Disease Pathology and Targeted Therapies.

    KIT Mutations and Other Genetic Defects in Mastocytosis: Implications for Disease Pathology and Targeted Therapies.
    Chantran Y, Valent P, Arock M.

    10/24/2023
    Golgi retention and oncogenic KIT signaling via PLCgamma2-PKD2-PI4KIIIbeta activation in gastrointestinal stromal tumor cells.

    Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells.
    Obata Y, Kurokawa K, Tojima T, Natsume M, Shiina I, Takahashi T, Abe R, Nakano A, Nishida T.

    10/5/2023
    PDGFRA, KIT, and KDR Gene Amplification in Glioblastoma: Heterogeneity and Clinical Significance.

    PDGFRA, KIT, and KDR Gene Amplification in Glioblastoma: Heterogeneity and Clinical Significance.
    Carlotto BS, Trevisan P, Provenzi VO, Soares FP, Rosa RFM, Varella-Garcia M, Zen PRG., Free PMC Article

    09/25/2023
    KIT D816V is dimerization-independent and activates downstream pathways frequently perturbed in mastocytosis.

    KIT D816V is dimerization-independent and activates downstream pathways frequently perturbed in mastocytosis.
    Rajan V, Prykhozhij SV, Pandey A, Cohen AM, Rainey JK, Berman JN.

    09/1/2023
    Bioinformatic analysis of KIT juxtamembrane domain mutations in Syrian GIST patients: jigsaw puzzle completed.

    Bioinformatic analysis of KIT juxtamembrane domain mutations in Syrian GIST patients: jigsaw puzzle completed.
    Pharaon N, Habbal W, Monem F.

    08/19/2023
    Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling.

    Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling.
    Cao X, Wu S, Wang X, Huang J, Zhang W, Liang C., Free PMC Article

    08/9/2023
    KIT A502_Y503 duplication mutation serves as a potential and universal target for neoantigen peptide in Chinese GIST patients.

    KIT A502_Y503 duplication mutation serves as a potential and universal target for neoantigen peptide in Chinese GIST patients.
    Liu F, Wang Q, Li Y, Li L, Shi J, Fan X, Pan Q, Li R.

    08/7/2023
    c-Kit signaling potentiates CAR T cell efficacy in solid tumors by CD28- and IL-2-independent co-stimulation.

    c-Kit signaling potentiates CAR T cell efficacy in solid tumors by CD28- and IL-2-independent co-stimulation.
    Xiong Y, Taleb M, Misawa K, Hou Z, Banerjee S, Amador-Molina A, Jones DR, Chintala NK, Adusumilli PS.,

    08/3/2023
    Mechanism of immune escape mediated by receptor tyrosine kinase KIT in thyroid cancer.

    Mechanism of immune escape mediated by receptor tyrosine kinase KIT in thyroid cancer.
    Luo Z, Xu J, Xu D, Xu J, Zhou R, Deng K, Chen Z, Zou F, Yao L, Hu Y., Free PMC Article

    08/1/2023
    Whole-genome and Epigenomic Landscapes of Malignant Gastrointestinal Stromal Tumors Harboring KIT Exon 11 557-558 Deletion Mutations.

    Whole-genome and Epigenomic Landscapes of Malignant Gastrointestinal Stromal Tumors Harboring KIT Exon 11 557-558 Deletion Mutations.
    Ohshima K, Nagashima T, Fujiya K, Hatakeyama K, Watanabe Y, Morimoto K, Kamada F, Shimoda Y, Ohnami S, Naruoka A, Serizawa M, Ohnami S, Kenmotsu H, Shiomi A, Tsubosa Y, Bando E, Sugiura T, Sugino T, Terashima M, Uesaka K, Urakami K, Akiyama Y, Yamaguchi K., Free PMC Article

    07/3/2023
    Comparison of circulating tumor DNA between African American and Caucasian patients with metastatic castrate-resistant prostate cancer post-abiraterone and/or enzalutamide.

    Comparison of circulating tumor DNA between African American and Caucasian patients with metastatic castrate-resistant prostate cancer post-abiraterone and/or enzalutamide.
    Jang A, Lanka SM, Huang M, Casado CV, Caputo SA, Sweeney PL, Gupta K, Pocha O, Habibian N, Hawkins ME, Lieberman AD, Schwartz J, Jaeger EB, Miller PJ, Layton JL, Barata PC, Lewis BE, Ledet EM, Sartor O.

    06/29/2023
    Clorfl86/RHEX Is a Negative Regulator of SCF/KIT Signaling in Human Skin Mast Cells.

    Clorfl86/RHEX Is a Negative Regulator of SCF/KIT Signaling in Human Skin Mast Cells.
    Franke K, Bal G, Li Z, Zuberbier T, Babina M., Free PMC Article

    05/19/2023
    Low c-Kit expression identifies primitive, therapy-resistant CML stem cells.

    Low c-Kit expression identifies primitive, therapy-resistant CML stem cells.
    Shah M, Kumar H, Qiu S, Li H, Harris M, He J, Abraham A, Crossman DK, Paterson A, Welner RS, Bhatia R., Free PMC Article

    01/14/2023
    Mechanism of KIT gene regulation by GATA1 lacking the N-terminal domain in Down syndrome-related myeloid disorders.

    Mechanism of KIT gene regulation by GATA1 lacking the N-terminal domain in Down syndrome-related myeloid disorders.
    Kanezaki R, Toki T, Terui K, Sato T, Kobayashi A, Kudo K, Kamio T, Sasaki S, Kawaguchi K, Watanabe K, Ito E., Free PMC Article

    12/17/2022
    Identification and in silico analysis of noval alteration Arg420Gly in KIT proto oncogene among acute myeloid leukemia patients.

    Identification and in silico analysis of noval alteration Arg420Gly in KIT proto oncogene among acute myeloid leukemia patients.
    Akram AM, Hassan M, Chaudhary A, Hayat S, Ali Q, Hussain T, Zafar A, Javed MA., Free PMC Article

    11/19/2022
    Gastrointestinal stromal tumors caused by novel germline variants in SDHB and KIT: a report of two cases and literature review.

    Gastrointestinal stromal tumors caused by novel germline variants in SDHB and KIT: a report of two cases and literature review.
    Rasmussen S, Stueck A, Colwell B, Gaston D, Carter M.

    10/29/2022
    Effect of miR-129-3p on autophagy of interstitial cells of Cajal in slow transit constipation through SCF C-kit signaling pathway.

    Effect of miR-129-3p on autophagy of interstitial cells of Cajal in slow transit constipation through SCF C-kit signaling pathway.
    Wang H, Ren B, Pan J, Fu S, Liu C, Sun D.

    10/15/2022
    Role and significance of c-KIT receptor tyrosine kinase in cancer: A review.

    Role and significance of c-KIT receptor tyrosine kinase in cancer: A review.
    Sheikh E, Tran T, Vranic S, Levy A, Bonfil RD., Free PMC Article

    10/15/2022
    A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML.

    A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML.
    Cai B, Liu Y, Chong Y, Mori SF, Matsunaga A, Zhang H, Fang X, Chang CS, Cowell JK, Hu T., Free PMC Article

    08/6/2022
    KIT promotes tumor stroma formation and counteracts tumor-suppressive TGFbeta signaling in colorectal cancer.

    KIT promotes tumor stroma formation and counteracts tumor-suppressive TGFβ signaling in colorectal cancer.
    Küçükköse E, Peters NA, Ubink I, van Keulen VAM, Daghighian R, Verheem A, Laoukili J, Kranenburg O., Free PMC Article

    07/30/2022
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