| LKB1 deficiency induces an autocrine INSL4 signaling that critically supports the growth and survival of lung cancer cells. Therefore, aberrant INSL4 signaling is a promising therapeutic target for LKB1-deficient lung cancers. | Role of INSL4 Signaling in Sustaining the Growth and Viability of LKB1-Inactivated Lung Cancer.
Yang R, Li SW, Chen Z, Zhou X, Ni W, Fu DA, Lu J, Kaye FJ, Wu L., Free PMC Article | 07/11/2020 |
| Report decreased INSL4 gene expression in both the invasive and the noninvasive areas of villous trophoblast in patients with placenta accreta. | Relaxin, its receptor (RXFP1), and insulin-like peptide 4 expression through gestation and in placenta accreta.
Goh W, Yamamoto SY, Thompson KS, Bryant-Greenwood GD., Free PMC Article | 01/11/2014 |
| A tight interaction between HER-2 gene and EPIL in invasive breast cancer cells is probable. | [Expression of early placenta insulin-like growth factor (EPIL) in breast cancer cells provides an autocrine loop with enhancement of predominantly HER-2-related invasivity].
Bürger H, Kemming D, Helms M, Feldmann U, Matuschek A, Böcker W, Brandt B. | 01/21/2010 |
| Expression of the INSL4 gene was doubled in the placenta of the growth-restricted twin compared to the normally grown sibling, suggesting that it may be linked to a higher level of apoptosis and loss of cell viability | Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth.
Millar L, Streiner N, Webster L, Yamamoto S, Okabe R, Kawamata T, Shimoda J, Büllesbach E, Schwabe C, Bryant-Greenwood G., Free PMC Article | 01/21/2010 |
| We identified an INSL4 alternatively spliced mRNA species that encodes putative novel INSL4-like peptides. | Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element.
Bièche I, Laurent A, Laurendeau I, Duret L, Giovangrandi Y, Frendo JL, Olivi M, Fausser JL, Evain-Brion D, Vidaud M. | 01/21/2010 |