| LRRTM3 polymorphisms may play a role in the pathogenesis of late-onset Alzheimer's disease (LOAD) in a Northern Han Chinese population. | Association of LRRTM3 polymorphisms with late-onset Alzheimer's disease in Han Chinese.
Wang J, Yu JT, Jiang T, Tan MS, Wang HF, Tan L, Hu N, Sun L, Zhang W, Tan L. | 12/6/2014 |
| protein interactions between LRRTM3, APP and BACE1, as well as complex associations between mRNA levels of LRRTM3, CTNNA3, APP and BACE1 in humans might influence APP metabolism and ultimately risk of AD | LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).
Lincoln S, Allen M, Cox CL, Walker LP, Malphrus K, Qiu Y, Nguyen T, Rowley C, Kouri N, Crook J, Pankratz VS, Younkin S, Younkin L, Carrasquillo M, Zou F, Abdul-Hay SO, Springer W, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Lewis JM, Dickson D, Graff-Radford NR, Petersen RC, Eckman E, Younkin SG, Ertekin-Taner N., Free PMC Article | 10/4/2014 |
| LRRTM3 is not an essential regulator of amyloid-beta production in adult mice; there are no differences in genotype between levels of Abeta or Abeta protein precursor C-terminal fragments in vivo. | LRRTM3 is dispensable for amyloid-β production in mice.
Laakso T, Muggalla P, Kysenius K, Laurén J, Paatero A, Huttunen HJ, Airaksinen MS. | 07/13/2013 |
| One single-nucleotide polymorphism in the promoter region and a block of 4 single-nucleotide polymorphisms in intron 2 were associated with AD in the National Institute on Aging Late-Onset Alzheimer's Disease data set or the Caribbean Hispanic data set. | Effect of genetic variation in LRRTM3 on risk of Alzheimer disease.
Reitz C, Conrad C, Roszkowski K, Rogers RS, Mayeux R., Free PMC Article | 11/24/2012 |
| Apart from the complexity of its regulation, alterations in both CTNNA3 and LRTMM3 are implicated in human disease. | Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest.
Smith JD, Meehan MH, Crean J, McCann A. | 09/10/2011 |
| An ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3 in Alzheimer disease. | An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.
Edwards TL, Pericak-Vance M, Gilbert JR, Haines JL, Martin ER, Ritchie MD, Edwards TL, Pericak-Vance M, Gilbert JR, Haines JL, Martin ER, Ritchie MD., Free PMC Articles: PMC2821734, PMC2821734 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesPolymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry.
Sousa I, Clark TG, Holt R, Pagnamenta AT, Mulder EJ, Minderaa RB, Bailey AJ, Battaglia A, Klauck SM, Poustka F, Monaco AP, International Molecular Genetic Study of Autism Consortium (IMGSAC). An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.
Edwards TL, Pericak-Vance M, Gilbert JR, Haines JL, Martin ER, Ritchie MD, Edwards TL, Pericak-Vance M, Gilbert JR, Haines JL, Martin ER, Ritchie MD. | 01/11/2009 |
| Data suggest that LRRTM3 is a functional and positional candidate gene for Alzheimer disease, and, given its receptor-like structure and restricted expression, a potential therapeutic target. | LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.
Majercak J, Ray WJ, Espeseth A, Simon A, Shi XP, Wolffe C, Getty K, Marine S, Stec E, Ferrer M, Strulovici B, Bartz S, Gates A, Xu M, Huang Q, Ma L, Shughrue P, Burchard J, Colussi D, Pietrak B, Kahana J, Beher D, Rosahl T, Shearman M, Hazuda D, Sachs AB, Koblan KS, Seabrook GR, Stone DJ., Free PMC Article | 01/21/2010 |